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Article

Immunocytochemical stem cell markers can predict clinical stage of breast cancer

  • Authors:
    • Pedro J. Gutiérrez Diez
    • Yanrong Su
    • Jose Russo
  • View Affiliations / Copyright

    Affiliations: Department of Economic Theory, University of Valladolid, School of Economics, Valladolid, Spain, The Irma H. Russo, MD - Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA
  • Pages: 1507-1516
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    Published online on: July 14, 2017
       https://doi.org/10.3892/or.2017.5820
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Abstract

We present a computational-statistical algorithm that, from data on the staining degree of immunocytochemical markers: i) evaluates the ability of the considered immuno­panel in predicting the breast cancer stage; ii) makes the accurate identification of breast cancer stage possible; iii) provides the best stage prognosis compatible with the considered sample; and iv) does so through the use of the minimum number of markers minimizing time and resource costs. After running the algorithm on two data sets [triple-negative breast cancer, (TNBC), and estrogen receptor-negative breast cancer, (ERNBC)], we conclude that EpCAM and β1 integrin are enough to accurately predict TNBC stage, being ALDH1, CD24, CD61, and CK5 the necessary markers to exactly predict ERNBC stage.
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Copy and paste a formatted citation
Spandidos Publications style
Gutiérrez Diez PJ, Su Y and Russo J: Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Oncol Rep 38: 1507-1516, 2017.
APA
Gutiérrez Diez, P.J., Su, Y., & Russo, J. (2017). Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Oncology Reports, 38, 1507-1516. https://doi.org/10.3892/or.2017.5820
MLA
Gutiérrez Diez, P. J., Su, Y., Russo, J."Immunocytochemical stem cell markers can predict clinical stage of breast cancer". Oncology Reports 38.3 (2017): 1507-1516.
Chicago
Gutiérrez Diez, P. J., Su, Y., Russo, J."Immunocytochemical stem cell markers can predict clinical stage of breast cancer". Oncology Reports 38, no. 3 (2017): 1507-1516. https://doi.org/10.3892/or.2017.5820
Copy and paste a formatted citation
x
Spandidos Publications style
Gutiérrez Diez PJ, Su Y and Russo J: Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Oncol Rep 38: 1507-1516, 2017.
APA
Gutiérrez Diez, P.J., Su, Y., & Russo, J. (2017). Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Oncology Reports, 38, 1507-1516. https://doi.org/10.3892/or.2017.5820
MLA
Gutiérrez Diez, P. J., Su, Y., Russo, J."Immunocytochemical stem cell markers can predict clinical stage of breast cancer". Oncology Reports 38.3 (2017): 1507-1516.
Chicago
Gutiérrez Diez, P. J., Su, Y., Russo, J."Immunocytochemical stem cell markers can predict clinical stage of breast cancer". Oncology Reports 38, no. 3 (2017): 1507-1516. https://doi.org/10.3892/or.2017.5820
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