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Article

Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer

  • Authors:
    • Xiaonan Fu
    • Xuan Mao
    • Yuxiang Wang
    • Xianfeng Ding
    • Yongfeng Li
  • View Affiliations / Copyright

    Affiliations: College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, P.R. China, Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China
  • Pages: 1851-1856
    |
    Published online on: July 19, 2017
       https://doi.org/10.3892/or.2017.5839
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Abstract

In this study, we found that let-7c-5p expression was clearly downregulated in breast cancer tissues compared with that of corresponding adjacent tissues. Furthermore, overexpression of let-7c-5p in MCF-7 breast cancer cells could significantly inhibit cell proliferation and induce cell apoptosis. The target genes of let-7c-5p were predicted by the way of bioinformatics, and validated by dual luciferase reporter assay and western blotting demonstrating that excision repair cross complementing 6 (ERCC6) gene was a direct target. Collectively, the present study suggested that let-7c-5p acted as a tumor suppressor in breast cancer possibly by negatively regulating ERCC6, which took an important part in nucleotide excision repair and it may provide a new potential strategy for breast cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Fu X, Mao X, Wang Y, Ding X and Li Y: Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer. Oncol Rep 38: 1851-1856, 2017.
APA
Fu, X., Mao, X., Wang, Y., Ding, X., & Li, Y. (2017). Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer. Oncology Reports, 38, 1851-1856. https://doi.org/10.3892/or.2017.5839
MLA
Fu, X., Mao, X., Wang, Y., Ding, X., Li, Y."Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer". Oncology Reports 38.3 (2017): 1851-1856.
Chicago
Fu, X., Mao, X., Wang, Y., Ding, X., Li, Y."Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer". Oncology Reports 38, no. 3 (2017): 1851-1856. https://doi.org/10.3892/or.2017.5839
Copy and paste a formatted citation
x
Spandidos Publications style
Fu X, Mao X, Wang Y, Ding X and Li Y: Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer. Oncol Rep 38: 1851-1856, 2017.
APA
Fu, X., Mao, X., Wang, Y., Ding, X., & Li, Y. (2017). Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer. Oncology Reports, 38, 1851-1856. https://doi.org/10.3892/or.2017.5839
MLA
Fu, X., Mao, X., Wang, Y., Ding, X., Li, Y."Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer". Oncology Reports 38.3 (2017): 1851-1856.
Chicago
Fu, X., Mao, X., Wang, Y., Ding, X., Li, Y."Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer". Oncology Reports 38, no. 3 (2017): 1851-1856. https://doi.org/10.3892/or.2017.5839
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