Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer

  • Authors:
    • Xiaonan Fu
    • Xuan Mao
    • Yuxiang Wang
    • Xianfeng Ding
    • Yongfeng Li
  • View Affiliations

  • Published online on: July 19, 2017     https://doi.org/10.3892/or.2017.5839
  • Pages: 1851-1856
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In this study, we found that let-7c-5p expression was clearly downregulated in breast cancer tissues compared with that of corresponding adjacent tissues. Furthermore, overexpression of let-7c-5p in MCF-7 breast cancer cells could significantly inhibit cell proliferation and induce cell apoptosis. The target genes of let-7c-5p were predicted by the way of bioinformatics, and validated by dual luciferase reporter assay and western blotting demonstrating that excision repair cross complementing 6 (ERCC6) gene was a direct target. Collectively, the present study suggested that let-7c-5p acted as a tumor suppressor in breast cancer possibly by negatively regulating ERCC6, which took an important part in nucleotide excision repair and it may provide a new potential strategy for breast cancer therapy.
View Figures
View References

Related Articles

Journal Cover

September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fu X, Mao X, Wang Y, Ding X and Li Y: Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer. Oncol Rep 38: 1851-1856, 2017
APA
Fu, X., Mao, X., Wang, Y., Ding, X., & Li, Y. (2017). Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer. Oncology Reports, 38, 1851-1856. https://doi.org/10.3892/or.2017.5839
MLA
Fu, X., Mao, X., Wang, Y., Ding, X., Li, Y."Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer". Oncology Reports 38.3 (2017): 1851-1856.
Chicago
Fu, X., Mao, X., Wang, Y., Ding, X., Li, Y."Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer". Oncology Reports 38, no. 3 (2017): 1851-1856. https://doi.org/10.3892/or.2017.5839