Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling

  • Authors:
    • Shibo Wei
    • Qing Fan
    • Liang Yang
    • Xiaodong Zhang
    • Yingbo Ma
    • Zhihong Zong
    • Xiangdong Hua
    • Dongming Su
    • Hongzhi Sun
    • Hangyu Li
    • Zhen Liu
  • View Affiliations

  • Published online on: July 20, 2017     https://doi.org/10.3892/or.2017.5840
  • Pages: 1902-1908
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Abstract

The long non-coding RNA HOX transcript antisense RNA (HOTAIR) plays a key role in the progression of various carcinomas. However, whether or not HOTAIR influences glucose metabolism and the specific underlying mechanism in hepatocellular carcinoma (HCC) cells remain unclear. In the present study, we found markedly increased HOTAIR expression in 84 HCC tissues and demonstrated that HOTAIR overexpression promoted cell proliferation using Cell Counting Kit-8. The effect on glucose metabolism regulated by HOTAIR in HCC cells was determined by detecting lactate and glucose levels: HOTAIR promoted glycolysis by upregulating glucose transporter isoform 1 (GLUT1) and activating mammalian target of rapamycin (mTOR) signaling, whereas knockdown of HOTAIR suppressed this effect. Our research reveals a novel relationship between HOTAIR and glucose metabolism in HCC cells, and it may be a therapeutic target for diagnosing and treating HCC.
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September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wei S, Fan Q, Yang L, Zhang X, Ma Y, Zong Z, Hua X, Su D, Sun H, Li H, Li H, et al: Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling. Oncol Rep 38: 1902-1908, 2017.
APA
Wei, S., Fan, Q., Yang, L., Zhang, X., Ma, Y., Zong, Z. ... Liu, Z. (2017). Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling. Oncology Reports, 38, 1902-1908. https://doi.org/10.3892/or.2017.5840
MLA
Wei, S., Fan, Q., Yang, L., Zhang, X., Ma, Y., Zong, Z., Hua, X., Su, D., Sun, H., Li, H., Liu, Z."Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling". Oncology Reports 38.3 (2017): 1902-1908.
Chicago
Wei, S., Fan, Q., Yang, L., Zhang, X., Ma, Y., Zong, Z., Hua, X., Su, D., Sun, H., Li, H., Liu, Z."Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling". Oncology Reports 38, no. 3 (2017): 1902-1908. https://doi.org/10.3892/or.2017.5840