MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1

Retraction in: /10.3892/or.2023.8640

  • Authors:
    • Chunyan Tian
    • Jun Li
    • Lili Ren
    • Ren Peng
    • Binbin Chen
    • Yumei Lin
  • View Affiliations

  • Published online on: September 14, 2017     https://doi.org/10.3892/or.2017.5956
  • Pages: 3071-3077
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Accumulating evidence has demonstrated that aberrant miRNAs were involved in carcinogenesis and tumor progression by regulating oncogenes or tumor suppressor expression. Dysregulation of miR-381 has been reported in different tumors. However, the clinical roles and underlying mechanism in non-small cell lung cancer (NSCLC) remains to be elucidated. We found the expression of miR-381 was significantly downregulated in both NSCLC tissues and cell lines. Clinical analysis revealed the reduced miR-381 was obviously associated with advanced TNM stage and lymph node metastasis. Moreover, we disclosed that miR-381 was a novel independent prognostic marker for predicting 5-year survival of NSCLC patients. The ectopic overexpression of miR-381 inhibited cell migration and invasion in vitro and in vivo. Notably, miR-381 could modulate LRH-1 by directly binding to its 3'-UTR. In clinical samples of NSCLC, miR-381 inversely correlated with LRH-1 expression, which performed positive roles in NSCLC migration and invasion. Alteration of LRH-1 expression at least partially abolished the migration and invasion of miR-381 on NSCLC cells. Here, we identified LRH-1 as a functional target of miR-381 in NSCLC. In conclusion, our data indicated that miR-381 inhibited migration and invasion of NSCLC by targeting LRH-1, and may represent a novel potential therapeutic target and prognostic marker for NSCLC.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tian C, Li J, Ren L, Peng R, Chen B and Lin Y: MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1 Retraction in /10.3892/or.2023.8640. Oncol Rep 38: 3071-3077, 2017
APA
Tian, C., Li, J., Ren, L., Peng, R., Chen, B., & Lin, Y. (2017). MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1 Retraction in /10.3892/or.2023.8640. Oncology Reports, 38, 3071-3077. https://doi.org/10.3892/or.2017.5956
MLA
Tian, C., Li, J., Ren, L., Peng, R., Chen, B., Lin, Y."MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1 Retraction in /10.3892/or.2023.8640". Oncology Reports 38.5 (2017): 3071-3077.
Chicago
Tian, C., Li, J., Ren, L., Peng, R., Chen, B., Lin, Y."MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1 Retraction in /10.3892/or.2023.8640". Oncology Reports 38, no. 5 (2017): 3071-3077. https://doi.org/10.3892/or.2017.5956