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SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway

  • Authors:
    • Jianming Liao
    • Xiang Tao
    • Qianshan Ding
    • Junhui Liu
    • Xue Yang
    • Fan-En Yuan
    • Ji-An Yang
    • Baohui Liu
    • Guo-An Xiang
    • Qianxue Chen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Gastroenterology, Institute for Gastroenterology and Hepatology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of General Surgery, The Second People's Hospital of Guangdong Province, The Third Clinical Medicine School, Southern Medical University, Guangzhou, Guangdong 510317, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2667-2676
    |
    Published online on: September 21, 2017
       https://doi.org/10.3892/or.2017.5982
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Abstract

Structure-specific recognition protein 1 (SSRP1) has been considered as a potential biomarker, since aberrant high expression of SSRP1 has been detected in numerous malignant tumors. However, the correlation between the expression level of SSRP1 and glioma remains unclear. The present study attempted to investigate the role of SSRP1 in the pathogenesis of glioma. In the present study, our data revealed that SSRP1 overexpression was detected in glioma tissues at both the mRNA and protein levels using quantitative real-time RT-PCR and immunohistochemical analysis. We also demonstrated that the upregulated expression of SSRP1 was correlated with the World Health Organization (WHO) grade of glioma. The knockdown of SSRP1 by siRNA not only resulted in the inhibition of cell proliferation, but also significantly inhibited glioma cell migration and invasion. Mechanistic analyses revealed that SSRP1 depletion suppressed the activity of the phosphorylation of the MAPK signaling pathway. In conclusion, the present study indicated that SSRP1 regulated the proliferation and metastasis of glioma cells via the MAPK signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Liao J, Tao X, Ding Q, Liu J, Yang X, Yuan F, Yang J, Liu B, Xiang G, Chen Q, Chen Q, et al: SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway. Oncol Rep 38: 2667-2676, 2017.
APA
Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F. ... Chen, Q. (2017). SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway. Oncology Reports, 38, 2667-2676. https://doi.org/10.3892/or.2017.5982
MLA
Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F., Yang, J., Liu, B., Xiang, G., Chen, Q."SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway". Oncology Reports 38.5 (2017): 2667-2676.
Chicago
Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F., Yang, J., Liu, B., Xiang, G., Chen, Q."SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway". Oncology Reports 38, no. 5 (2017): 2667-2676. https://doi.org/10.3892/or.2017.5982
Copy and paste a formatted citation
x
Spandidos Publications style
Liao J, Tao X, Ding Q, Liu J, Yang X, Yuan F, Yang J, Liu B, Xiang G, Chen Q, Chen Q, et al: SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway. Oncol Rep 38: 2667-2676, 2017.
APA
Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F. ... Chen, Q. (2017). SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway. Oncology Reports, 38, 2667-2676. https://doi.org/10.3892/or.2017.5982
MLA
Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F., Yang, J., Liu, B., Xiang, G., Chen, Q."SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway". Oncology Reports 38.5 (2017): 2667-2676.
Chicago
Liao, J., Tao, X., Ding, Q., Liu, J., Yang, X., Yuan, F., Yang, J., Liu, B., Xiang, G., Chen, Q."SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway". Oncology Reports 38, no. 5 (2017): 2667-2676. https://doi.org/10.3892/or.2017.5982
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