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Article

Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression

  • Authors:
    • Jang Mi Han
    • Haet Nim Lim
    • Hye Jin Jung
  • View Affiliations / Copyright

    Affiliations: Department of BT-Convergent Pharmaceutical Engineering, Sun Moon University, Tangjeong-myeon, Asan-si, Chungnam 336-708, Republic of Korea
  • Pages: 3430-3438
    |
    Published online on: October 11, 2017
       https://doi.org/10.3892/or.2017.6021
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Abstract

Specific inhibition of angiogenesis has been considered a powerful strategy for the treatment of cancer and other angiogenesis-related human diseases. Hovenia dulcis Thunb., Japanese raisin tree or Oriental raisin tree, is a hardy tree found in Asia, Eastern China and Korea and has been known to possess various biological activities, including antifatigue, antidiabetic, neuroprotective and hepatoprotective activity. In the present study, for the first time, we evaluated whether a 100% ethanol extract of Hovenia dulcis Thunb. (HDT) inhibits the angiogenesis of human umbilical vein endothelial cells (HUVECs) using in vitro angiogenesis assays. HDT suppressed vascular endothelial growth factor (VEGF)-induced proliferation, migration, invasion and tube formation of HUVECs at subtoxic doses. In addition, HDT significantly inhibited in vivo angiogenesis of the chorioallantoic membrane from growing chick embryos without exhibiting cytotoxicity. Furthermore, HDT downregulated not only VEGF receptor 2 (VEGFR2) signaling in HUVECs, but also hypoxia-inducible factor (HIF)-1α expression in hepatocarcinoma cell line HepG2. Ampelopsin is a bioactive flavanonol found in Hovenia dulcis Thunb. Our data showed that ampelopsin inhibited angiogenesis with no cytotoxicity by suppressing both VEGFR2 signaling and HIF-1α expression. These results suggest that Hovenia dulcis Thunb. and its active compound ampelopsin exhibit potent antiangiogenic activities and therefore could be valuable for the prevention and treatment of angiogenesis-related diseases including cancer.
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1 

Folkman J: Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 333:1757–1763. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Risau W: Mechanisms of angiogenesis. Nature. 386:671–674. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Karamysheva AF: Mechanisms of angiogenesis. Biochemistry (Mosc). 73:751–762. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Holash J, Wiegand SJ and Yancopoulos GD: New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene. 18:5356–5362. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Holmes K, Roberts OL, Thomas AM and Cross MJ: Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition. Cell Signal. 19:2003–2012. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Stetler-Stevenson WG: Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention. J Clin Invest. 103:1237–1241. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Baldin V, Lukas J, Marcote MJ, Pagano M and Draetta G: Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 7:812–821. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Semenza GL: Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 15:551–578. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Höckel M and Vaupel P: Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 93:266–276. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Greer SN, Metcalf JL, Wang Y and Ohh M: The updated biology of hypoxia-inducible factor. EMBO J. 31:2448–2460. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD and Semenza GL: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 16:4604–4613. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Fan TP, Yeh JC, Leung KW, Yue PY and Wong RN: Angiogenesis: From plants to blood vessels. Trends Pharmacol Sci. 27:297–309. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Avramis IA, Kwock R and Avramis VI: Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines. Anticancer Res. 21:2281–2286. 2001.PubMed/NCBI

14 

Clements MK, Jones CB, Cumming M and Daoud SS: Antiangiogenic potential of camptothecin and topotecan. Cancer Chemother Pharmacol. 44:411–416. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Vincent L, Kermani P, Young LM, Cheng J, Zhang F, Shido K, Lam G, Bompais-Vincent H, Zhu Z, Hicklin DJ, et al: Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest. 115:2992–3006. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Lee JH, Choi S, Lee Y, Lee HJ, Kim KH, Ahn KS, Bae H, Lee HJ, Lee EO, Ahn KS, et al: Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades. Mol Cancer Ther. 9:389–399. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Han JM, Kwon HJ and Jung HJ: Tricin, 4′,5,7-trihydroxy-3′,5′-dimethoxyflavone, exhibits potent antiangiogenic activity in vitro. Int J Oncol. 49:1497–1504. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Yang J, Wu S and Li C: High efficiency secondary somatic embryogenesis in Hovenia dulcis Thunb. through solid and liquid cultures. Sci World J. 2013:7187542013. View Article : Google Scholar

19 

Na CS, Yoon SY, Kim JB, Na DS, Dong MS, Lee MY and Hong CY: Anti-fatigue activity of Hovenia dulcis on a swimming mouse model through the inhibition of stress hormone expression and antioxidation. Am J Chin Med. 41:945–955. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ji Y, Chen S, Zhang K and Wang W: Effects of Hovenia dulcis Thunb on blood sugar and hepatic glycogen in diabetic mice. Zhong Yao Cai. 25:190–191. 2002.(In Chinese). PubMed/NCBI

21 

Li G, Min BS, Zheng C, Lee J, Oh SR, Ahn KS and Lee HK: Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis. Arch Pharm Res. 28:804–809. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Hase K, Ohsugi M, Xiong Q, Basnet P, Kadota S and Namba T: Hepatoprotective effect of Hovenia dulcis THUNB. on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. Biol Pharm Bull. 20:381–385. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Park JS, Kim IS, Shaheed Ur Rehman, Na CS and Yoo HH: HPLC determination of bioactive flavonoids in Hovenia dulcis fruit extracts. J Chromatogr Sci. 54:130–135. 2016.PubMed/NCBI

24 

Weng L, Zhang H, Li X, Zhan H, Chen F, Han L, Xu Y and Cao X: Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-κB and JAK2/STAT3 signaling pathways in microglia. Int Immunopharmacol. 44:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Hou X, Zhang J, Ahmad H, Zhang H, Xu Z and Wang T: Evaluation of antioxidant activities of ampelopsin and its protective effect in lipopolysaccharide-induced oxidative stress piglets. PLoS One. 9:e1083142014. View Article : Google Scholar : PubMed/NCBI

26 

Zhou Y, Liang X, Chang H, Shu F, Wu Y, Zhang T, Fu Y, Zhang Q, Zhu JD and Mi M: Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress. Cancer Sci. 105:1279–1287. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Parast CV, Mroczkowski B, Pinko C, Misialek S, Khambatta G and Appelt K: Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis. Biochemistry. 37:16788–16801. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Hicklin DJ and Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 23:1011–1027. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Olsson AK, Dimberg A, Kreuger J and Claesson-Welsh L: VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 7:359–371. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Verheul HM and Pinedo HM: Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer. 7:475–485. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Newman DJ and Cragg GM: Natural products as sources of new drugs over the last 25 years. J Nat Prod. 70:461–477. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Kim B, Woo MJ, Park CS, Lee SH, Kim JS, Kim B, An S and Kim SH: Hovenia dulcis extract reduces lipid accumulation in oleic acid-induced steatosis of Hep G2 cells via activation of AMPK and PPARα/CPT-1 pathway and in acute hyperlipidemia mouse model. Phytother Res. 31:132–139. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Park JY, Moon JY, Park SD, Park WH, Kim H and Kim JE: Fruits extracts of Hovenia dulcis Thunb. suppresses lipopolysaccharide-stimulated inflammatory responses through nuclear factor-kappaB pathway in Raw 264.7 cells. Asian Pac J Trop Med. 9:357–365. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Liang X, Zhang T, Shi L, Kang C, Wan J, Zhou Y, Zhu J and Mi M: Ampelopsin protects endothelial cells from hyperglycemia-induced oxidative damage by inducing autophagy via the AMPK signaling pathway. Biofactors. 41:463–475. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Chen XM, Xie XB, Zhao Q, Wang F, Bai Y, Yin JQ, Jiang H, Xie XL, Jia Q and Huang G: Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells. Mol Med Rep. 11:105–112. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Cho SG, Yi Z, Pang X, Yi T, Wang Y, Luo J, Wu Z, Li D and Liu M: Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation. Cancer Res. 69:7062–7070. 2009. View Article : Google Scholar : PubMed/NCBI

37 

El-Kenawi AE and El-Remessy AB: Angiogenesis inhibitors in cancer therapy: Mechanistic perspective on classification and treatment rationales. Br J Pharmacol. 170:712–729. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Chen SH, Murphy DA, Lassoued W, Thurston G, Feldman MD and Lee WM: Activated STAT3 is a mediator and biomarker of VEGF endothelial activation. Cancer Biol Ther. 7:1994–2003. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Jung HJ, Kim Y, Chang J, Kang SW, Kim JH and Kwon HJ: Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells. J Mol Med (Berl). 91:1117–1128. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Ushio-Fukai M: VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal. 9:731–739. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han JM, Lim HN and Jung HJ: Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression. Oncol Rep 38: 3430-3438, 2017.
APA
Han, J.M., Lim, H.N., & Jung, H.J. (2017). Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression. Oncology Reports, 38, 3430-3438. https://doi.org/10.3892/or.2017.6021
MLA
Han, J. M., Lim, H. N., Jung, H. J."Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression". Oncology Reports 38.6 (2017): 3430-3438.
Chicago
Han, J. M., Lim, H. N., Jung, H. J."Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression". Oncology Reports 38, no. 6 (2017): 3430-3438. https://doi.org/10.3892/or.2017.6021
Copy and paste a formatted citation
x
Spandidos Publications style
Han JM, Lim HN and Jung HJ: Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression. Oncol Rep 38: 3430-3438, 2017.
APA
Han, J.M., Lim, H.N., & Jung, H.J. (2017). Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression. Oncology Reports, 38, 3430-3438. https://doi.org/10.3892/or.2017.6021
MLA
Han, J. M., Lim, H. N., Jung, H. J."Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression". Oncology Reports 38.6 (2017): 3430-3438.
Chicago
Han, J. M., Lim, H. N., Jung, H. J."Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression". Oncology Reports 38, no. 6 (2017): 3430-3438. https://doi.org/10.3892/or.2017.6021
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