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Article

Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target

  • Authors:
    • Zujun Sun
    • Qi Liu
    • Dongxia Ye
    • Kaichuang Ye
    • Zhenhua Yang
    • Dong Li
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China, Department of Clinical Laboratory, Baoshan Traditional Chinese and Western Medicine Hospital, Shanghai 201900, P.R. China, Shanghai Research Institute of Stomatology, Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200011, P.R. China, Vascular Surgery, Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200011, P.R. China
  • Pages: 209-216
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/or.2017.6073
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Abstract

Mesenchymal-epithelial transition factor (c-Met) is the only high affinity receptor for hepatocyte growth factor (HGF), and is frequently activated in many human cancers. However, little is known about the role of the HGF/c-Met signaling pathway in the progression of human oral squamous cell carcinoma (OSCC). This study evaluated the role of the HGF/c-Met signaling pathway in the progression of human OSCC. We found that the expression of c-Met was significantly increased in human OSCC tissues than in normal mucosa adjacent to the tumor (P<0.05), but was not correlated with clinicopathological parameters. Additionally, the selective c-Met inhibitor JNJ was found to inhibit cell viability and migration and promote apoptosis in OSCC cell lines, and also blocked the activation AKT, ERK1/2, and NF-κB p65; thus, suggesting that HGF/c-Met signaling may play an important role in the tumorigenic properties of OSCC cells via the AKT, ERK1/2, and NF-κB pathways. Collectively, these results indicated that HGF/c-Met signaling may serve essential roles in the progression of human OSCC, and may thus be a basis for the development of novel therapeutic approaches in the treatment of OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Z, Liu Q, Ye D, Ye K, Yang Z and Li D: Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncol Rep 39: 209-216, 2018.
APA
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., & Li, D. (2018). Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncology Reports, 39, 209-216. https://doi.org/10.3892/or.2017.6073
MLA
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., Li, D."Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target". Oncology Reports 39.1 (2018): 209-216.
Chicago
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., Li, D."Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target". Oncology Reports 39, no. 1 (2018): 209-216. https://doi.org/10.3892/or.2017.6073
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Z, Liu Q, Ye D, Ye K, Yang Z and Li D: Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncol Rep 39: 209-216, 2018.
APA
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., & Li, D. (2018). Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncology Reports, 39, 209-216. https://doi.org/10.3892/or.2017.6073
MLA
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., Li, D."Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target". Oncology Reports 39.1 (2018): 209-216.
Chicago
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., Li, D."Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target". Oncology Reports 39, no. 1 (2018): 209-216. https://doi.org/10.3892/or.2017.6073
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