Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2018 Volume 39 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 39 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells

  • Authors:
    • Zachariah Payne Sellers
    • Kamila Bujko
    • Gabriela Schneider
    • Magdalena Kucia
    • Mariusz Z. Ratajczak
  • View Affiliations / Copyright

    Affiliations: Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA, Department of Regenerative Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland
  • Pages: 851-859
    |
    Published online on: November 24, 2017
       https://doi.org/10.3892/or.2017.6108
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The pituitary sex hormones (SexHs): follicle‑stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) regulate several functions crucial for reproduction, including oogenesis, spermatogenesis, and lactation. An important source of prolactin-like hormones, known as lactogens, is the placenta, and lactogens bind to the PRL receptor (PRLR) with high affinity and thereby mimic the actions of PRL. Recently, it has been demonstrated that pituitary SexHs were involved in metastatic lung cancer, certain sarcomas, and leukemia. In the present study we aimed to investigate whether FSH, LH, and PRL were able to stimulate stem cells involved in early development. To address this issue we employed a murine embryonic stem cell line (ES-D3) as well as two teratocarcinoma cell lines, P19 (murine) and NTera2 (human). We determined that all these cells expressed SexH receptors at the mRNA and protein levels and that stimulation of these receptors induced phosphorylation of p42/44 MAPK, p38 MAPK, and AKT. Moreover, ES-D3, P19, and NTera2 cells responded with increased migration and adhesion to physiological concentrations of pituitary SexHs. In view of these findings we proposed that maternal-derived pituitary SexHs regulate the biology of stem cells involved in early development.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Costa MA: The endocrine function of human placenta: An overview. Reprod Biomed Online. 32:14–43. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Pepe GJ and Albrecht ED: Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev. 16:608–648. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Whitaker-Azmitia PM, Lobel M and Moyer A: Low maternal progesterone may contribute to both obstetrical complications and autism. Med Hypotheses. 82:313–318. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Gürbüz B, Yalti S, Ozden S and Ficicioglu C: High basal estradiol level and FSH/LH ratio in unexplained recurrent pregnancy loss. Arch Gynecol Obstet. 270:37–39. 2004. View Article : Google Scholar : PubMed/NCBI

5 

van Kruchten M, van der Marel P, de Munck L, Hollema H, Arts H, Timmer-Bosscha H, de Vries E, Hospers G and Reyners A: Hormone receptors as a marker of poor survival in epithelial ovarian cancer. Gynecol Oncol. 138:634–639. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lønning PE: Poor-prognosis estrogen receptor-positive disease: Present and future clinical solutions. Ther Adv Med Oncol. 4:127–137. 2012. View Article : Google Scholar : PubMed/NCBI

7 

García-Cruz E, Piqueras M, Huguet J, Peri L, Izquierdo L, Musquera M, Franco A, Alvarez-Vijande R, Ribal MJ and Alcaraz A: Low testosterone levels are related to poor prognosis factors in men with prostate cancer prior to treatment. BJU Int. 110:E541–E546. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Ma CX, Bose R and Ellis MJ: Prognostic and predictive biomarkers of endocrine responsiveness for estrogen receptor positive breast cancer. Adv Exp Med Biol. 882:125–154. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Abdelbaset-Ismail A, Pedziwiatr D, Schneider G, Niklinski J, Charkiewicz R, Moniuszko M, Kucia M and Ratajczak MZ: Pituitary sex hormones enhance the pro metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase 1. Int J Oncol. 50:317–328. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Poniewierska-Baran A, Schneider G, Sun W, Abdelbaset-Ismail A, Barr FG and Ratajczak MZ: Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications. Int J Oncol. 48:1815–1824. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Abdelbaset-Ismail A, Borkowska S, Janowska-Wieczorek A, Tonn T, Rodriguez C, Moniuszko M, Bolkun L, Koloczko J, Eljaszewicz A, Ratajczak J, et al: Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells. Oncotarget. 7:3033–3046. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Donovan PJ and Gearhart J: The end of the beginning for pluripotent stem cells. Nature. 414:92–97. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Otte J, Wruck W and Adjaye J: New insights into human primordial germ cells and early embryonic development from single-cell analysis. FEBS Lett. 591:2226–2240. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Aflatoonian B and Moore H: Germ cells from mouse and human embryonic stem cells. Reproduction. 132:699–707. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Kucia M, Halasa M, Wysoczynski M, Baskiewicz-Masiuk M, Moldenhawer S, Zuba-Surma E, Czajka R, Wojakowski W, Machalinski B and Ratajczak MZ: Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: Preliminary report. Leukemia. 21:297–303. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Ratajczak MZ, Shin DM, Liu R, Marlicz W, Tarnowski M, Ratajczak J and Kucia M: Epiblast/germ line hypothesis of cancer development revisited: Lesson from the presence of Oct-4+ cells in adult tissues. Stem Cell Rev. 6:307–316. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Ratajczak MZ, Schneider G, Sellers ZP, Kucia M and Kakar SS: The embryonic rest hypothesis of cancer development - an old XIX century theory revisited. J Cancer Stem Cell Res. 2:e10012014.

18 

Virchow R: Editorial Archive fuer pathologische. Anatomie und Physiologie fuer klinische Medizin. 8:23–54. 1855.(In German).

19 

Conheim J: Congenitales, quergestreiftes muskelsarkon der nireren. Virchows Arch. 65:64–69. 1875.(In German). View Article : Google Scholar

20 

Mierzejewska K, Borkowska S, Suszynska E, Suszynska M, Poniewierska-Baran A, Maj M, Pedziwiatr D, Adamiak M, Abdel-Latif A, Kakar SS, et al: Hematopoietic stem/progenitor cells express several functional sex hormone receptors-novel evidence for a potential developmental link between hematopoiesis and primordial germ cells. Stem Cells Dev. 24:927–937. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Abdelbaset-Ismail A, Suszynska M, Borkowska S, Adamiak M, Ratajczak J, Kucia M and Ratajczak MZ: Human haematopoietic stem/progenitor cells express several functional sex hormone receptors. J Cell Mol Med. 20:134–146. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Patel H and Bhartiya D: Testicular stem cells express follicle-stimulating hormone receptors and are directly modulated by FSH. Reprod Sci. 23:1493–1508. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Patel H, Bhartiya D, Parte S, Gunjal P, Yedurkar S and Bhatt M: Follicle stimulating hormone modulates ovarian stem cells through alternately spliced receptor variant FSH-R3. J Ovarian Res. 6:522013. View Article : Google Scholar : PubMed/NCBI

24 

Shaikh A, Anand S, Kapoor S, Ganguly R and Bhartiya D: Mouse bone marrow VSELs exhibit differentiation into three embryonic germ lineages and germ & hematopoietic cells in culture. Stem Cell Rev. 13:202–216. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Ratajczak MZ, Bartke A and Darzynkiewicz Z: Prolonged growth hormone/insulin/insulin-like growth factor nutrient response signaling pathway as a silent killer of stem cells and a culprit in aging. Stem Cell Rev. 13:443–453. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Sellers ZP, Schneider G, Bujko K, Suszynska M and Pedziwiatr D: Do cancer cell lines have fixed or fluctuating stem cell phenotypes? - studies with the NTera2 cell line. Stem Cell Rev. 13:603–610. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Schneider G, Glaser T, Lameu C, Abdelbaset-Ismail A, Sellers ZP, Moniuszko M, Ulrich H and Ratajczak MZ: Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Mol Cancer. 14:2012015. View Article : Google Scholar : PubMed/NCBI

28 

Gertler A, Bignon C, Staten NR, Sakal E, Tchelet A, Krivi GG and Djiane J: Proceedings of the Society for Experimental Biology and Medicine: Interaction of lactogenic hormones with the soluble extracellular domain of prolactin receptors. Proc Soc Exp Biol Med. 206:pp. 273–279. 1994; View Article : Google Scholar : PubMed/NCBI

29 

Fischbach F and Dunning MB: A Manual of Laboratory and Diagnostic Tests. 9th. Wolters Kluwer Health/Lippincott Williams & Wilkins; Philadelphia: 2014

30 

Araujo AB and Wittert GA: Endocrinology of the aging male. Best Pract Res Clin Endocrinol Metab. 25:303–319. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Limpaphayom K, Taechakraichana N and Kittinunvorakoon C: Serum estradiol and gonadotropins level in postmenopausal women with or without hormone replacement. J Med Assoc Thai. 80:147–152. 1997.PubMed/NCBI

32 

Androutsos G, Karamanou M, Stamboulis E, Tsoucalas G, Kousoulis AA and Mandelenaki D: Joseph-Claude-Anthelme Récamier (1774–1852): Forerunner in surgical oncology. J BUON. 16:572–576. 2011.PubMed/NCBI

33 

Remak R: Ein beitrag zur entwickelungsgeschichte der krebshaften geschwulste Deut Klin. 6:70–174. 1854.(In German).

34 

Durante F: Arch. Memori ed Osservazioni di Chirugia Practica. 11:217–226. 1874.(In Italian).

35 

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, et al: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41–49. 2002. View Article : Google Scholar : PubMed/NCBI

36 

D'Ippolito G, Diabira S, Howard GA, Menei P, Roos BA and Schiller PC: Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci. 117:2971–2981. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Beltrami AP, Cesselli D, Bergamin N, Marcon P, Rigo S, Puppato E, D'Aurizio F, Verardo R, Piazza S, Pignatelli A, et al: Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow). Blood. 110:3438–3446. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Goldenberg-Cohen N, Avraham-Lubin BC, Sadikov T, Goldstein RS and Askenasy N: Primitive stem cells derived from bone marrow express glial and neuronal markers and support revascularization in injured retina exposed to ischemic and mechanical damage. Stem Cells Dev. 21:1488–1500. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Vacanti MP, Roy A, Cortiella J, Bonassar L and Vacanti CA: Identification and initial characterization of spore-like cells in adult mammals. J Cell Biochem. 80:455–460. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Howell JC, Lee WH, Morrison P, Zhong J, Yoder MC and Srour EF: Pluripotent stem cells identified in multiple murine tissues. Ann NY Acad Sci. 996:158–173. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, et al: Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci USA. 108:pp. 9875–9880. 2011; View Article : Google Scholar : PubMed/NCBI

42 

Guerin CL, Rossi E, Saubamea B, Cras A, Mignon V, Silvestre JS and Smadja DM: Human very small embryonic-like cells support vascular maturation and therapeutic revascularization induced by endothelial progenitor cells. Stem Cell Rev. 13:552–560. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Golipoor Z, Mehraein F, Zafari F, Alizadeh A, Ababzadeh S and Baazm M: Migration of bone marrow-derived very small embryonic-like stem cells toward an injured spinal cord. Cell J. 17:639–647. 2016.PubMed/NCBI

44 

Bhartiya D, Shaikh A, Anand S, Patel H, Kapoor S, Sriraman K, Parte S and Unni S: Endogenous, very small embryonic-like stem cells: Critical review, therapeutic potential and a look ahead. Hum Reprod Update. 23:41–76. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH and Krause DS: Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Stem Cells. 31:2759–2766. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Ratajczak MZ, Ratajczak J, Suszynska M, Miller DM, Kucia M and Shin DM: A novel view of the adult stem cell compartment from the perspective of a quiescent population of very small embryonic-like stem cells. Circ Res. 120:166–178. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Majka M, Drukala J, Lesko E, Wysoczynski M, Jenson AB and Ratajczak MZ: SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells. Folia Histochem Cytobiol. 44:155–164. 2006.PubMed/NCBI

48 

Schneider G, Sellers ZP, Bujko K, Kakar SS, Kucia M and Ratajczak MZ: Novel pleiotropic effects of bioactive phospholipids in human lung cancer metastasis. Oncotarget. 8:58247–58263. 2017.PubMed/NCBI

49 

Schneider G, Bryndza E, Poniewierska-Baran A, Serwin K, Suszynska M, Sellers ZP, Merchant ML, Kaliappan A, Ratajczak J, Kucia M, et al: Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: A novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities. Oncotarget. 7:69829–69843. 2016.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sellers ZP, Bujko K, Schneider G, Kucia M and Ratajczak MZ: Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. Oncol Rep 39: 851-859, 2018.
APA
Sellers, Z.P., Bujko, K., Schneider, G., Kucia, M., & Ratajczak, M.Z. (2018). Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. Oncology Reports, 39, 851-859. https://doi.org/10.3892/or.2017.6108
MLA
Sellers, Z. P., Bujko, K., Schneider, G., Kucia, M., Ratajczak, M. Z."Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells". Oncology Reports 39.2 (2018): 851-859.
Chicago
Sellers, Z. P., Bujko, K., Schneider, G., Kucia, M., Ratajczak, M. Z."Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells". Oncology Reports 39, no. 2 (2018): 851-859. https://doi.org/10.3892/or.2017.6108
Copy and paste a formatted citation
x
Spandidos Publications style
Sellers ZP, Bujko K, Schneider G, Kucia M and Ratajczak MZ: Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. Oncol Rep 39: 851-859, 2018.
APA
Sellers, Z.P., Bujko, K., Schneider, G., Kucia, M., & Ratajczak, M.Z. (2018). Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. Oncology Reports, 39, 851-859. https://doi.org/10.3892/or.2017.6108
MLA
Sellers, Z. P., Bujko, K., Schneider, G., Kucia, M., Ratajczak, M. Z."Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells". Oncology Reports 39.2 (2018): 851-859.
Chicago
Sellers, Z. P., Bujko, K., Schneider, G., Kucia, M., Ratajczak, M. Z."Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells". Oncology Reports 39, no. 2 (2018): 851-859. https://doi.org/10.3892/or.2017.6108
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team