Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells

  • Authors:
    • Zachariah Payne Sellers
    • Kamila Bujko
    • Gabriela Schneider
    • Magdalena Kucia
    • Mariusz Z. Ratajczak
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/or.2017.6108
  • Pages: 851-859
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Abstract

The pituitary sex hormones (SexHs): follicle‑stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) regulate several functions crucial for reproduction, including oogenesis, spermatogenesis, and lactation. An important source of prolactin-like hormones, known as lactogens, is the placenta, and lactogens bind to the PRL receptor (PRLR) with high affinity and thereby mimic the actions of PRL. Recently, it has been demonstrated that pituitary SexHs were involved in metastatic lung cancer, certain sarcomas, and leukemia. In the present study we aimed to investigate whether FSH, LH, and PRL were able to stimulate stem cells involved in early development. To address this issue we employed a murine embryonic stem cell line (ES-D3) as well as two teratocarcinoma cell lines, P19 (murine) and NTera2 (human). We determined that all these cells expressed SexH receptors at the mRNA and protein levels and that stimulation of these receptors induced phosphorylation of p42/44 MAPK, p38 MAPK, and AKT. Moreover, ES-D3, P19, and NTera2 cells responded with increased migration and adhesion to physiological concentrations of pituitary SexHs. In view of these findings we proposed that maternal-derived pituitary SexHs regulate the biology of stem cells involved in early development.
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February-2018
Volume 39 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sellers ZP, Bujko K, Schneider G, Kucia M and Ratajczak MZ: Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. Oncol Rep 39: 851-859, 2018
APA
Sellers, Z.P., Bujko, K., Schneider, G., Kucia, M., & Ratajczak, M.Z. (2018). Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells. Oncology Reports, 39, 851-859. https://doi.org/10.3892/or.2017.6108
MLA
Sellers, Z. P., Bujko, K., Schneider, G., Kucia, M., Ratajczak, M. Z."Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells". Oncology Reports 39.2 (2018): 851-859.
Chicago
Sellers, Z. P., Bujko, K., Schneider, G., Kucia, M., Ratajczak, M. Z."Novel evidence that pituitary sex hormones regulate migration, adhesion, and proliferation of embryonic stem cells and teratocarcinoma cells". Oncology Reports 39, no. 2 (2018): 851-859. https://doi.org/10.3892/or.2017.6108