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Article

Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06

  • Authors:
    • Di Wu
    • Da-Wei Zhao
    • Yong-Qi Li
    • Wei-Guo Shi
    • Qi-Liang Yin
    • Zheng-Kun Tu
    • Ying-Ying Yu
    • Bo-Hua Zhong
    • Hong Yu
    • Wan-Guo Bao
  • View Affiliations / Copyright

    Affiliations: Cancer Centre, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Breast Tumor, Jilin Province Tumor Hospital, Changchun, Jilin 130012, P.R. China, Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, Beijing 100850, P.R. China, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130061, P.R. China, Cell Biology Laboratory, Jilin Province Institute of Cancer Prevention and Treatment, Jilin Cancer Hospital, Changchun, Jilin 130021, P.R. China, Department of Infectious Disease, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 871-879
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/or.2017.6143
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Abstract

Camptothecin (CPT) is a cytotoxic quinoline alkaloid that is used clinically as an anticancer drug. However, the clinical application of CPT is limited due to its low solubility as well as serious and unfathomable side-effects. In the present study, we created a novel 10-hydroxy CPT prodrug, ZBH-ZM‑06. Its cellular cytotoxic activity was analyzed in terms of cellular viability, acetylcholinesterase (AchE) inhibition, DNA relaxation, cellular cycling and apoptosis properties. Our results showed that the AchE inhibition rate of 10 µmol/l ZBH-ZM-06 was 12.5%, compared to 96.5% for carbonyl-oxycamptothecin (CPT-11). In a chemical stability assay, only 4.9% of ZBH-ZM-06 remained after 4 h at pH 7.4. In addition, 10 µmol/l ZBH-ZM-06 significantly inhibited the tumor cell viability of nine tumor cell lines, compared to CPT-11 and the CPT active ingredient, 7-ethyl-10-hydroxy-camptothecin (SN38) (p<0.01-0.05). In the apoptosis assay, ZBH-ZM-06 increased the ratio of annexin V+/propidium iodide (PI)-/+ cells by flow cytometric analysis (p<0.05). Moreover, ZBH-ZM-06 activated caspase-3 and poly(ADP-ribose)polymerase (PARP) expression by immunoblotting. Furthermore, ZBH-ZM-06 induced a greater G2/M phase arrest ratio, compared to CPT-11 and SN38. These results indicated that ZBH-ZM-06 had higher antitumor activity than CPT-11 and SN38, which was shown by its: i) release of the effective ingredient; ii) growth inhibition of a broad spectrum of tumor cells; iii) inhibition of DNA topoisomerase (Topo-1); and iv) promotion of apoptosis through an intrinsic signaling pathway. Thus, ZBH-ZM-06 may be applied in the preclinic study for cancer treatment.
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1 

Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT and Sim GA: Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata1,2. J Am Chem Soc. 88:3888–3890. 1966. View Article : Google Scholar

2 

Lin RW, Yang CN, Ku S, Ho CJ, Huang SB, Yang MC, Chang HW, Lin CM, Hwang J, Chen YL, et al: CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA. PLoS One. 9:e1138322014. View Article : Google Scholar : PubMed/NCBI

3 

Tomicic MT and Kaina B: Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. Biochim Biophys Acta. 1835:11–27. 2013.PubMed/NCBI

4 

Joerger M, Hess D, Delmonte A, Gallerani E, Fasolo A, Gianni L, Cresta S, Barbieri P, Pace S and Sessa C: Integrative population pharmacokinetic and pharmacodynamic dose finding approach of the new camptothecin compound namitecan (ST1968). Br J Clin Pharmacol. 80:128–138. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Joerger M, Hess D, Delmonte A, Gallerani E, Barbieri P, Pace S and Sessa C: Phase-I dose finding and pharmacokinetic study of the novel hydrophilic camptothecin ST-1968 (namitecan) in patients with solid tumors. Invest New Drugs. 33:472–479. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Naumczuk B, Kawęcki R, Bocian W, Bednarek E, Sitkowski J and Kozerski L: Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2. Magn Reson Chem. 55:128–136. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Hamilton G, Klameth L, Rath B and Thalhammer T: Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines. Molecules. 19:2077–2088. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Vladu B, Woynarowski JM, Manikumar G, Wani MC, Wall ME, Von Hoff DD and Wadkins RM: 7- and 10-substituted campto-thecins: Dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents. Mol Pharmacol. 57:243–251. 2000.PubMed/NCBI

9 

Chazin EL, Reis RR, Junior WT, Moor LF and Vasconcelos TR: An overview on the development of new potentially active camptothecin analogs against cancer. Mini Rev Med Chem. 14:953–962. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zubovych IO, Sethi A, Kulkarni A, Tagal V and Roth MG: A novel inhibitor of topoisomerase I is selectively toxic for a subset of non-small cell lung cancer cell lines. Mol Cancer Ther. 15:23–36. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Liu YP, Chen HL, Tzeng CC, Lu PJ, Lo CW, Lee YC, Tseng CH, Chen YL and Yang CN: TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells. Breast Cancer Res Treat. 138:383–393. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Jeansonne DP, Koh GY, Zhang F, Kirk-Ballard H, Wolff L, Liu D, Eilertsen K and Liu Z: Paclitaxel-induced apoptosis is blocked by camptothecin in human breast and pancreatic cancer cells. Oncol Rep. 25:1473–1480. 2011.PubMed/NCBI

13 

Numbenjapon T, Wang J, Colcher D, Schluep T, Davis ME, Duringer J, Kretzner L, Yen Y, Forman SJ and Raubitschek A: Preclinical results of camptothecin-polymer conjugate (IT-101) in multiple human lymphoma xenograft models. Clin Cancer Res. 15:4365–4373. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Morandi E, Severini C, Quercioli D, DArio G, Perdichizzi S, Capri M, Farruggia G, Mascolo MG, Horn W, Vaccari M, et al: Gene expression time-series analysis of camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines. Mol Cancer. 7:662008. View Article : Google Scholar : PubMed/NCBI

15 

Chen YL, Chueh FS, Yang JS, Hsueh SC, Lu CC, Chiang JH, Lee CS, Lu HF and Chung JG: Antitumor effects with apoptotic death in human promyelocytic leukemia HL-60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl. Environ Toxicol. 30:803–815. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Yao Y, Su X, Xie Y, Wang Y, Kang T, Gou L, Yi C and Yang J: Synthesis, characterization, and antitumor evaluation of the albumin-SN38 conjugate. Anticancer Drugs. 24:270–277. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Meco D, Di Francesco AM, Cusano G, Bucci F, Pierri F, Patriarca V, Torella AR, Pisano C and Riccardi R: Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models. Cancer Chemother Pharmacol. 70:811–822. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Yu LM, Zhang XR, Li XB, Yang Y, Wei HY, He XX, Gu LQ, Huang ZS, Pommier Y and An LK: Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors. Eur J Med Chem. 101:525–533. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Fukuda Y, Kanbe M, Watanabe M, Dan K, Matsuzaki K, Kitanaka S and Miyata S: 3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells. Arch Pharm Res. 36:1029–1038. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Zhou M, Liu M, He X, Yu H, Wu D, Yao Y, Fan S, Zhang P, Shi W and Zhong B: Synthesis and biological evaluation of novel 10-substituted-7-ethyl-10-hydroxycamptothecin (SN-38) prodrugs. Molecules. 19:19718–19731. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Wu D, Shi W, Zhao J, Wei Z, Chen Z, Zhao D, Lan S, Tai J, Zhong B and Yu H: Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205. Arch Biochem Biophys. 604:74–85. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Shoemaker RH: The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer. 6:813–823. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Rivory LP, Bowles MR, Robert J and Pond SM: Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase. Biochem Pharmacol. 52:1103–1111. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Senter PD, Beam KS, Mixan B and Wahl AF: Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug. Bioconjug Chem. 12:1074–1080. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Atyabi F, Farkhondehfai A, Esmaeili F and Dinarvand R: Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice. Acta Pharm. 59:133–144. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Lansiaux A, Léonce S, Kraus-Berthier L, Bal-Mahieu C, Mazinghien R, Didier S, David-Cordonnier MH, Hautefaye P, Lavielle G, Bailly C, et al: Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs. Mol Pharmacol. 72:311–319. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Liu H, Lu H, Liao L, Zhang X, Gong T and Zhang Z: Lipid nanoparticles loaded with 7-ethyl-10-hydroxycamptothecin-phospholipid complex: In vitro and in vivo studies. Drug Deliv. 22:701–709. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Zhou S, Li N, Wang X, Li C, Tian F, Ren S, Zhang Y, He Y, Qiu Z, Zhao D, et al: In vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38. Xenobiotica. 44:562–569. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Demarquay D, Huchet M, Coulomb H, Lesueur-Ginot L, Lavergne O, Camara J, Kasprzyk PG, Prévost G and Bigg DC: BN80927: A novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo. Cancer Res. 64:4942–4949. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM and Potter PM: Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chem Biol Interact 157–158. 1–252. 2005.

31 

Dodds HM, Hanrahan J and Rivory LR: The inhibition of acetylcholinesterase by irinotecan and related camptothecins: Key structural properties and experimental variables. Anticancer Drug Des. 16:239–246. 2001.PubMed/NCBI

32 

Patnaik A, Papadopoulos KP, Tolcher AW, Beeram M, Urien S, Schaaf LJ, Tahiri S, Bekaii-Saab T, Lokiec FM, Rezaï K, et al: Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer. Cancer Chemother Pharmacol. 71:1499–1506. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Wadkins RM, Bearss D, Manikumar G, Wani MC, Wall ME and Von Hoff DD: Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity. Curr Med Chem Anticancer Agents. 4:327–334. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Motwani M, Sirotnak FM, She Y, Commes T and Schwartz GK: Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells. Cancer Res. 62:3950–3955. 2002.PubMed/NCBI

35 

Liu YQ, Li WQ, Morris-Natschke SL, Qian K, Yang L, Zhu GX, Wu XB, Chen AL, Zhang SY, Nan X, et al: Perspectives on biologically active camptothecin derivatives. Med Res Rev. 35:753–789. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Li J, Ouyang Y, Zhang X, Zhou W, Wang F, Huang Z, Wang X, Chen Y, Zhang H and Fu L: Effect of HM910, a novel camptothecin derivative, on the inhibition of multiple myeloma cell growth in vitro and in vivo. Am J Cancer Res. 5:1000–1016. 2015.PubMed/NCBI

37 

Ohmori T, Podack ER, Nishio K, Takahashi M, Miyahara Y, Takeda Y, Kubota N, Funayama Y, Ogasawara H, Ohira T, et al: Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2. Biochem Biophys Res Commun. 192:30–36. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Zuco V, De Cesare M, Zaffaroni N, Lanzi C and Cassinelli G: PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins. Oncotarget. 6:8736–8749. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Cao Y, Jin ZX, Tong XP, Yue S, Sakai T, Kawanami T, Sawaki T, Miki M, Iwao H, Nakajima A, et al: Synergistic effects of topoisomerase I inhibitor, SN38, on Fas-mediated apoptosis. Anticancer Res. 30:3911–3917. 2010.PubMed/NCBI

40 

Di Francesco AM, Riccardi A, Barone G, Rutella S, Meco D, Frapolli R, Zucchetti M, DIncalci M, Pisano C, Carminati P, et al: The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: A comparative study with SN38 and topotecan. Biochem Pharmacol. 70:1125–1136. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu D, Zhao D, Li Y, Shi W, Yin Q, Tu Z, Yu Y, Zhong B, Yu H, Bao W, Bao W, et al: Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06. Oncol Rep 39: 871-879, 2018.
APA
Wu, D., Zhao, D., Li, Y., Shi, W., Yin, Q., Tu, Z. ... Bao, W. (2018). Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06. Oncology Reports, 39, 871-879. https://doi.org/10.3892/or.2017.6143
MLA
Wu, D., Zhao, D., Li, Y., Shi, W., Yin, Q., Tu, Z., Yu, Y., Zhong, B., Yu, H., Bao, W."Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06". Oncology Reports 39.2 (2018): 871-879.
Chicago
Wu, D., Zhao, D., Li, Y., Shi, W., Yin, Q., Tu, Z., Yu, Y., Zhong, B., Yu, H., Bao, W."Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06". Oncology Reports 39, no. 2 (2018): 871-879. https://doi.org/10.3892/or.2017.6143
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Zhao D, Li Y, Shi W, Yin Q, Tu Z, Yu Y, Zhong B, Yu H, Bao W, Bao W, et al: Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06. Oncol Rep 39: 871-879, 2018.
APA
Wu, D., Zhao, D., Li, Y., Shi, W., Yin, Q., Tu, Z. ... Bao, W. (2018). Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06. Oncology Reports, 39, 871-879. https://doi.org/10.3892/or.2017.6143
MLA
Wu, D., Zhao, D., Li, Y., Shi, W., Yin, Q., Tu, Z., Yu, Y., Zhong, B., Yu, H., Bao, W."Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06". Oncology Reports 39.2 (2018): 871-879.
Chicago
Wu, D., Zhao, D., Li, Y., Shi, W., Yin, Q., Tu, Z., Yu, Y., Zhong, B., Yu, H., Bao, W."Antitumor potential of a novel camptothecin derivative, ZBH-ZM-06". Oncology Reports 39, no. 2 (2018): 871-879. https://doi.org/10.3892/or.2017.6143
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