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Article

miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling

  • Authors:
    • Qingwei Wu
    • Yingying Zhao
    • Yiyuan Sun
    • Xiaojun Yan
    • Peihua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Ear, Nose and Throat, The Ninth Affliated Hospital of Shanghai Jiao Tong University, Shanghai 200011, P.R. China
  • Pages: 1461-1468
    |
    Published online on: January 2, 2018
       https://doi.org/10.3892/or.2018.6177
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Abstract

Upregulation of programmed death 1 ligand 1 (PD-L1) in cancer cells and its ligation to PD-1 on T cells facilitates cancer cell escape from immune surveillance. Therapies with PD-1 or PD-L1 antibodies have resulted in marked clinical responses in various cancer types. Hence, modulators that inhibit PD-L1 expression in cancer cells may serve as a novel strategy by which to enhance host immune responses. In the present study, we investigated the effects of miR-375 on PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells by qRT-PCR and western blot analyses. We confirmed that miR-375 inhibited IFN-γ-induced PD-L1 surface expression in HNSCC cells, and we observed that Janus kinase 2 (JAK2) is a bona fide target of miR-375 and further activated signal transducer and activator of transcription 1 (STAT1). Additionally, miR-375-mediated inhibition of PD-L1 expression was dependent on the JAK2/STAT1 pathway. Therefore, by attenuating PD-1/PD-L1 signaling, miR-375 may also serve as a modulator to increase the cell immune responses to HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Q, Zhao Y, Sun Y, Yan X and Wang P: miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling. Oncol Rep 39: 1461-1468, 2018.
APA
Wu, Q., Zhao, Y., Sun, Y., Yan, X., & Wang, P. (2018). miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling. Oncology Reports, 39, 1461-1468. https://doi.org/10.3892/or.2018.6177
MLA
Wu, Q., Zhao, Y., Sun, Y., Yan, X., Wang, P."miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling". Oncology Reports 39.3 (2018): 1461-1468.
Chicago
Wu, Q., Zhao, Y., Sun, Y., Yan, X., Wang, P."miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling". Oncology Reports 39, no. 3 (2018): 1461-1468. https://doi.org/10.3892/or.2018.6177
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Q, Zhao Y, Sun Y, Yan X and Wang P: miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling. Oncol Rep 39: 1461-1468, 2018.
APA
Wu, Q., Zhao, Y., Sun, Y., Yan, X., & Wang, P. (2018). miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling. Oncology Reports, 39, 1461-1468. https://doi.org/10.3892/or.2018.6177
MLA
Wu, Q., Zhao, Y., Sun, Y., Yan, X., Wang, P."miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling". Oncology Reports 39.3 (2018): 1461-1468.
Chicago
Wu, Q., Zhao, Y., Sun, Y., Yan, X., Wang, P."miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling". Oncology Reports 39, no. 3 (2018): 1461-1468. https://doi.org/10.3892/or.2018.6177
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