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Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma

  • Authors:
    • Da-Peng Yun
    • Yu-Qi Wang
    • De-Long Meng
    • Yuan-Yuan Ji
    • Ju-Xiang Chen
    • Hong-Yan Chen
    • Da-Ru Lu
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200438, P.R. China, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA, Department of Neurosurgery, Shanghai Institute of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
    Copyright: © Yun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1011-1022
    |
    Published online on: January 22, 2018
       https://doi.org/10.3892/or.2018.6225
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Abstract

Glioma is the most aggressive and malignant primary brain tumor in adults. In the present study, we identified a vital oncoprotein, capping actin protein, gelsolin-like (CapG), and investigated its roles in the prognosis, proliferation and metastasis in glioma. The mRNA and protein levels of CapG were significantly increased in human glioma, and higher CapG expression was an independent prognostic factor for predicting unfavorable prognosis. The expression level of CapG was found to be associated with several common molecular features of glioblastoma (GBM; WHO grade IV glioma) in The Cancer Genome Atlas (TCGA) cohort. When analyzing the prognosis of GBM patients according to these molecular features, we observed that the prognostic value of CapG was affected by amplification of CDK6 or EGFR. However, overexpression of CapG markedly promoted cell growth in vitro, while depletion of CapG significantly inhibited cell proliferation by blocking the cell cycle in G1/S transition. Moreover, CapG manipulation in glioma cell lines U87 and U251 showed CapG-dependent cellular migration and invasiveness. These data suggest that CapG may serve as a prognostic biomarker with potentially important therapeutic implications for glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Yun D, Wang Y, Meng D, Ji Y, Chen J, Chen H and Lu D: Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncol Rep 39: 1011-1022, 2018.
APA
Yun, D., Wang, Y., Meng, D., Ji, Y., Chen, J., Chen, H., & Lu, D. (2018). Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncology Reports, 39, 1011-1022. https://doi.org/10.3892/or.2018.6225
MLA
Yun, D., Wang, Y., Meng, D., Ji, Y., Chen, J., Chen, H., Lu, D."Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma". Oncology Reports 39.3 (2018): 1011-1022.
Chicago
Yun, D., Wang, Y., Meng, D., Ji, Y., Chen, J., Chen, H., Lu, D."Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma". Oncology Reports 39, no. 3 (2018): 1011-1022. https://doi.org/10.3892/or.2018.6225
Copy and paste a formatted citation
x
Spandidos Publications style
Yun D, Wang Y, Meng D, Ji Y, Chen J, Chen H and Lu D: Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncol Rep 39: 1011-1022, 2018.
APA
Yun, D., Wang, Y., Meng, D., Ji, Y., Chen, J., Chen, H., & Lu, D. (2018). Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncology Reports, 39, 1011-1022. https://doi.org/10.3892/or.2018.6225
MLA
Yun, D., Wang, Y., Meng, D., Ji, Y., Chen, J., Chen, H., Lu, D."Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma". Oncology Reports 39.3 (2018): 1011-1022.
Chicago
Yun, D., Wang, Y., Meng, D., Ji, Y., Chen, J., Chen, H., Lu, D."Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma". Oncology Reports 39, no. 3 (2018): 1011-1022. https://doi.org/10.3892/or.2018.6225
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