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Article

MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways

  • Authors:
    • Yan Feng
    • Li-Li Zu
    • Lei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Ultrasound, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116011, P.R. China, Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 2288-2296
    |
    Published online on: March 1, 2018
       https://doi.org/10.3892/or.2018.6289
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Abstract

We investigated the role of microRNA-26b signaling in mediating the tumor growth of human liver cancer. MicroRNA-26b expression was observably downregulated in human liver cancer tissue. Forced upregulation of microRNA-26b had anticancer effects, inhibited cell proliferation, induced apoptosis and promoted Bax and caspase-3/-9 protein expression in a liver cancer cell line as determined by MTT assay, flow cytometry and western blot analysis. MicroRNA-26b significantly suppressed the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. PI3K inhibitor significantly facilitated the effects of microRNA-26b regarding the suppression of the PI3K/Akt pathway, inhibition of cell proliferation, induction of apoptosis and increases in Bax and caspase-3/-9 protein expression in the liver cancer cell line. NF-κB inhibitor also significantly enhanced the effects of microRNA-26b regarding suppression of the NF-κB/MMP-9/VEGF pathway, inhibition of cell proliferation, induction of apoptosis, and promotion of Bax and caspase-3/-9 protein expression in the liver cancer cell line. The present study demonstrated that microRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Zu L and Zhang L: MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncol Rep 39: 2288-2296, 2018.
APA
Feng, Y., Zu, L., & Zhang, L. (2018). MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncology Reports, 39, 2288-2296. https://doi.org/10.3892/or.2018.6289
MLA
Feng, Y., Zu, L., Zhang, L."MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways". Oncology Reports 39.5 (2018): 2288-2296.
Chicago
Feng, Y., Zu, L., Zhang, L."MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways". Oncology Reports 39, no. 5 (2018): 2288-2296. https://doi.org/10.3892/or.2018.6289
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Zu L and Zhang L: MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncol Rep 39: 2288-2296, 2018.
APA
Feng, Y., Zu, L., & Zhang, L. (2018). MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncology Reports, 39, 2288-2296. https://doi.org/10.3892/or.2018.6289
MLA
Feng, Y., Zu, L., Zhang, L."MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways". Oncology Reports 39.5 (2018): 2288-2296.
Chicago
Feng, Y., Zu, L., Zhang, L."MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways". Oncology Reports 39, no. 5 (2018): 2288-2296. https://doi.org/10.3892/or.2018.6289
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