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Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma

  • Authors:
    • Zhiyuan Zhang
    • Sen Wang
    • Dongjian Ji
    • Wenwei Qian
    • Qingyuan Wang
    • Jie Li
    • Jiou Gu
    • Wen Peng
    • Tao Hu
    • Bing Ji
    • Yue Zhang
    • Shijia Wang
    • Yueming Sun
  • View Affiliations / Copyright

    Affiliations: The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2101-2113
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/or.2018.6296
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Abstract

Competing endogenous RNAs (ceRNAs) render the functions of long non‑coding RNAs (lncRNAs) more complicated during cancer processes. Potential lncRNA biomarkers and their roles as ceRNAs have not been clearly described for rectal adenocarcinoma (READ). In the present study, we extracted data from The Cancer Genome Atlas (TCGA) including data from 167 tumor samples and 10 adjacent non‑tumor samples. A total of 202 lncRNAs, 190 microRNAs (miRNAs) and 1,530 mRNAs were identified as READ‑specific RNAs [log2(fold‑change)>2, FDR<0.01]. The Gene Ontology (GO) biological processes and the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways were analysed for 1,530 specific mRNAs. Among 202 READ‑specific lncRNAs, 7 lncRNAs were identified as being associated with overall survival of READ patients. Then, a ceRNA network was constructed with 34 key lncRNAs, 25 miRNAs and 65 mRNAs. A total of 7 lncRNAs from the network were revealed to be linked to clinical features. The results of qRT‑PCR ascertained that our analysis was credible. Overall, this research provides a novel perspective from which to study the lncRNA‑related ceRNA network in READ and assists in the identification of new potential biomarkers to be used for diagnostic and prognostic purposes.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wang S, Ji D, Qian W, Wang Q, Li J, Gu J, Peng W, Hu T, Ji B, Ji B, et al: Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma. Oncol Rep 39: 2101-2113, 2018.
APA
Zhang, Z., Wang, S., Ji, D., Qian, W., Wang, Q., Li, J. ... Sun, Y. (2018). Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma. Oncology Reports, 39, 2101-2113. https://doi.org/10.3892/or.2018.6296
MLA
Zhang, Z., Wang, S., Ji, D., Qian, W., Wang, Q., Li, J., Gu, J., Peng, W., Hu, T., Ji, B., Zhang, Y., Wang, S., Sun, Y."Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma". Oncology Reports 39.5 (2018): 2101-2113.
Chicago
Zhang, Z., Wang, S., Ji, D., Qian, W., Wang, Q., Li, J., Gu, J., Peng, W., Hu, T., Ji, B., Zhang, Y., Wang, S., Sun, Y."Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma". Oncology Reports 39, no. 5 (2018): 2101-2113. https://doi.org/10.3892/or.2018.6296
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wang S, Ji D, Qian W, Wang Q, Li J, Gu J, Peng W, Hu T, Ji B, Ji B, et al: Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma. Oncol Rep 39: 2101-2113, 2018.
APA
Zhang, Z., Wang, S., Ji, D., Qian, W., Wang, Q., Li, J. ... Sun, Y. (2018). Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma. Oncology Reports, 39, 2101-2113. https://doi.org/10.3892/or.2018.6296
MLA
Zhang, Z., Wang, S., Ji, D., Qian, W., Wang, Q., Li, J., Gu, J., Peng, W., Hu, T., Ji, B., Zhang, Y., Wang, S., Sun, Y."Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma". Oncology Reports 39.5 (2018): 2101-2113.
Chicago
Zhang, Z., Wang, S., Ji, D., Qian, W., Wang, Q., Li, J., Gu, J., Peng, W., Hu, T., Ji, B., Zhang, Y., Wang, S., Sun, Y."Construction of a ceRNA network reveals potential lncRNA biomarkers in rectal adenocarcinoma". Oncology Reports 39, no. 5 (2018): 2101-2113. https://doi.org/10.3892/or.2018.6296
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