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Article

let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer

  • Authors:
    • Raúl García-Vázquez
    • Dolores Gallardo Rincón
    • Erika Ruiz-García
    • Abelardo Meneses García
    • Olga N. Hernández De La Cruz
    • Horacio Astudillo-De La Vega
    • David Isla-Ortiz
    • Laurence A. Marchat
    • Yarely M. Salinas-Vera
    • Ángeles Carlos-Reyes
    • Sullivan López-González
    • Rosalio Ramos-Payan
    • César López-Camarillo
  • View Affiliations / Copyright

    Affiliations: Molecular Biomedicine Program and Biotechnology Network, Instituto Politecnico Nacional, México City 07320, Mexico, Translational Medicine Laboratory, National Institute of Cancerology, México City 14080, Mexico, Translational Medicine Laboratory, National Institute of Cancerology, México City 14080, Mexico, Genomics Sciences Program, Autonomous University of Mexico City, México City 03100, Mexico, Laboratory of Translational Cancer Research and Cellular Therapy, National Medical Center ‘Century XXI’, México City 06720, Mexico, Department of Oncologic Surgery, National Institute of Cancerology, México City 14080, Mexico, Laboratory of Lung Cancer, National Institute of Respiratory Diseases ‘Ismael Cosio Villegas’, Mexico City 14080, Mexico, Sciences Faculty, Autonomous University of Culiacan, Culiacan Sinaloa 80040, Mexico
  • Pages: 3086-3094
    |
    Published online on: April 12, 2018
       https://doi.org/10.3892/or.2018.6366
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Abstract

Altered expression of microRNAs contributes to the heterogeneous biological behavior of human malignancies and it may correlate with the clinical pathological features of patients. The let-7 microRNA family is frequently downregulated in human cancers and its aberrant expression may be a useful marker for prediction of the clinical response to therapy in patients. In the present study, we analyzed the expression of three members of the let-7 family (let-7a-3p, let-7d-3p and let-7f), which remains largely uncharacterized in ovarian cancer tissues. We also investigated the function of let-7d-3p in the apoptosis and sensitization to chemotherapy in ovarian cancer cells. Our data from stem-loop quantitative RT-PCR showed that expression of let-7a-3p and let-7d-3p, but not let-7f, was significantly (P<0.04) upregulated in ovarian tumors relative to that noted in normal ovarian tissues. Markedly, an increased expression of let‑7d-3p (also known as let-7d-3*) was associated with positive response to carboplatin/paclitaxel treatment in ovarian cancer patients. To investigate the biological relevance of let‑7d-3p, we knocked down its expression in SKOV-3 ovarian cancer cell line using antagomiRs. Loss of function analysis showed that inhibition of let-7d-3p significantly (P<0.05) impaired cell proliferation and activated apoptosis. In contrast, scratch/wound healing and Transwell chamber assays showed that migration and invasion abilities were not affected in the let-7d-3p-deficient SKOV-3 cancer cells. Notably, Annexin V assays showed a significant (P<0.05) increase in cell death of cancer cells treated with the let-7d-3p inhibitor plus carboplatin indicating a synergistic effect of the drug with antagomiR therapy. Gene ontology classification of predicted targets of let-7d-3p identified a number of genes involved in cellular pathways associated with therapy resistance such as ABC transporters, HIF-1, RAS and ErbB signaling. In summary, our findings showed that inhibition of let-7d-3 activates apoptosis and that its upregulation is associated with a positive response of ovarian cancer patients to carboplatin/paclitaxel chemotherapy.
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View References

1 

Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol. 302:1–12. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Gonzalez H, Lema C, Kirken RA, Maldonado RA, Varela-Ramirez A and Aguilera RJ: Arsenic-exposed keratinocytes exhibit differential microRNAs expression profile; potential implication of miR-21, miR-200a and miR-141 in melanoma pathway. Clin Cancer Drugs. 2:138–147. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC and Yao Q: A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 19:5901–5913. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R and Hannon GJ: A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev. 21:3238–3243. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, et al: The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 15:7713–7722. 2007. View Article : Google Scholar

6 

Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA and Jacks T: Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci USA. 105:3903–3908. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Barh D, Malhotra R, Ravi B and Sindhurani P: MicroRNA let-7: An emerging next-generation cancer therapeutic. Curr Oncol. 17:70–80. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Vaughan S, Coward JI, Bast RC Jr, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, et al: Rethinking ovarian cancer: Recommendations for improving outcomes. Nat Rev Cancer. 11:719–725. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sandercock J, Parmar MK, Torri V and Qian W: First-line treatment for advanced ovarian cancer: Paclitaxel, platinum and the evidence. Br J Cancer. 87:815–824. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, Mannel RS, DeGeest K, Hartenbach EM and Baergen R: Gynecologic Oncology Group: Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: A Gynecologic Oncology Group study. J Clin Oncol. 21:3194–3200. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Greenlee RT, Hill-Harmon MB, Murray T and Thun M: Cancer statistics, 2001. CA Cancer J Clin. 51:15–36. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Siddik ZH: Cisplatin: Mode of cytotoxic action and molecular basis of resistance. Oncogene. 22:7265–7279. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Ledermann JA, Marth C, Carey MS, Birrer M, Bowtell DD, Kaye S, McNeish I, Oza A, Scambia G, Rustin G, et al: Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer. Int J Gynecol Cancer. 21:763–770. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Petrillo M, Zannoni GF, Beltrame L, Martinelli E, DiFeo A, Paracchini L, Craparotta I, Mannarino L, Vizzielli G, Scambia G, et al: Identification of high-grade serous ovarian cancer miRNA species associated with survival and drug response in patients receiving neoadjuvant chemotherapy: A retrospective longitudinal analysis using matched tumor biopsies. Ann Oncol. 27:625–634. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Li J, Zhang Y, Gao Y, Cui Y, Liu H, Li M and Tian Y: Downregulation of HNF1 homeobox B is associated with drug-resistance in ovarian cancer. Oncol Rep. 32:979–988. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ye XM, Zhu HY, Bai WD, Wang T, Wang L, Chen Y, Yang AG and Jia LT: Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R. BMC Cancer. 14:1342014. View Article : Google Scholar : PubMed/NCBI

18 

Pedroza-Torres A, Fernández-Retana J, Peralta-Zaragoza O, Jacobo-Herrera N, de Leon Cantu D, Cerna-Cortés JF, Lopez-Camarillo C and Pérez-Plasencia C: A microRNA expression signature for clinical response in locally advanced cervical cancer. Gynecol Oncol. 142:557–565. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Çalışkan M, Güler H and Çetintaş Bozok V: Current updates on microRNAs as regulators of chemoresistance. Biomed Pharmacother. 95:1000–1012. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Sun YL, Patel A, Kumar P and Chen ZS: Role of ABC transporters in cancer chemotherapy. Chin J Cancer. 31:51–57. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Sui H, Cai GX, Pan SF, Deng WL, Wang YW, Chen ZS, Cai SJ, Zhu HR and Li Q: miR-200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer. Mol Cancer Ther. 13:3137–3151. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Sorrentino A, Liu CG, Addario A, Peschle C, Scambia G and Ferlini C: Role of microRNAs in drug-resistant ovarian cancer cells. Gynecol Oncol. 111:478–486. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Samuel P, Pink RC, Brooks SA and Carter DR: miRNAs and ovarian cancer: A miRiad of mechanisms to induce cisplatin drug-resistance. Expert Rev Anticancer Ther. 16:57–70. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Boyerinas B, Park SM, Murmann AE, Gwin K, Montag AG, Zillhardt M, Hua YJ, Lengyel E and Peter ME: Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug-resistance 1. Int J Cancer. 130:1787–1797. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wu K, Yang Y, Zhao J and Zhao S: BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. Cancer Lett. 371:125–133. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhao L, Ren Y, Tang H, Wang W, He Q, Sun J, Zhou X and Wang A: Deregulation of the miR-222-ABCG2 regulatory module in tongue squamous cell carcinoma contributes to chemoresistance and enhanced migratory/invasive potential. Oncotarget. 6:44538–44550. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Ma Y, Li X, Cheng S, Wei W and Li Y: MicroRNA-106a confers cisplatin resistance in non-small cell lung cancer A549 cells by targeting adenosine triphosphatase-binding cassette A1. Mol Med Rep. 11:625–632. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Feng R and Dong L: Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells. Int J Clin Exp Pathol. 8:6107–6116. 2015.PubMed/NCBI

29 

Chen Z, Ma T, Huang C, Zhang L, Lv X, Xu T, Hu T and Li J: MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells. Cell Signal. 25:2693–2701. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Long QZ, Du YF, Liu XG, Li X and He DL: miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma. Tumour Biol. 36:7017–7026. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Zheng H, Liu Z, Liu T, Cai Y, Wang Y, Lin S, Chen J, Wang J, Wang Z and Jiang B: Fas signaling promotes chemoresistance in gastrointestinal cancer by up-regulating P-glycoprotein. Oncotarget. 15:10763–10777. 2014.

32 

Dong Z, Ren L, Lin L and Li J, Huang Y and Li J: Effect of microRNA-21 on multidrug-resistance reversal in A549/DDP human lung cancer cells. Mol Med Rep. 11:682–690. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Wuerkenbieke D, Wang J, Li Y and Ma C: miRNA-150 downregulation promotes pertuzumab resistance in ovarian cancer cells via AKT activation. Arch Gynecol Obstet. 292:1109–1116. 2015. View Article : Google Scholar : PubMed/NCBI

34 

De Mattos-Arruda L, Bottai G, Nuciforo PG, Di Tommaso L, Giovannetti E, Peg V, Losurdo A, Perez-Garcia J, Masci G, Corsi F, et al: MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients. Oncotarget. 10:37269–37280. 2015.

35 

Ma T, Yang L and Zhang J: miRNA-542-3p downregulation promotes trastuzumab resistance in breast cancer cells via AKT activation. Oncol Rep. 33:1215–1220. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Iorio MV, Casalini P, Piovan C, Di Leva G, Merlo A, Triulzi T, Ménard S, Croce CM and Tagliabue E: microRNA-205 regulates HER3 in human breast cancer. Cancer Res. 69:2195–2200. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Jin K, Park S, Teo WW, Korangath P, Cho SS, Yoshida T, Győrffy B, Goswami CP, Nakshatri H, Cruz LA, et al: HOXB7 Is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance. Cancer Discov. 5:944–959. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Kim Y, Kim H, Park D, Han M, Lee H, Lee YS, Choe J, Kim YM and Jeoung D: miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2. Oncotarget. 7:10297–10321. 2016.PubMed/NCBI

39 

Xu Y, Huang J, Ma L, Shan J, Shen J, Yang Z, Liu L, Luo Y, Yao C and Qian C: MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways. Cancer Lett. 371:171–181. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Xu B, Niu X, Zhang X, Tao J, Wu D, Wang Z, Li P, Zhang W, Wu H, Feng N, et al: miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS. Mol Cell Biochem. 350:207–213. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Sun Y, Chen C, Zhang P, Xie H, Hou L, Hui Z, Xu Y, Du Q, Zhou X, Su B and Gao W: Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. Sci Rep. 4:65272014. View Article : Google Scholar : PubMed/NCBI

42 

Dai X, Jiang Y and Tan C: Let-7 sensitizes KRAS mutant tumor cells to chemotherapy. PLoS One. 10:e01266532015. View Article : Google Scholar : PubMed/NCBI

43 

Amankwatia EB, Chakravarty P, Carey FA, Weidlich S, Steele RJ, Munro AJ, Wolf CR and Smith G: MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms. Br J Cancer. 112:1480–1490. 2015. View Article : Google Scholar : PubMed/NCBI

44 

van Jaarsveld MT, van Kuijk PF, Boersma AW, Helleman J, van IJcken WF, Mathijssen RH, Pothof J, Berns EM, Verweij J and Wiemer EA: miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway. Mol Cancer. 14:1962015. View Article : Google Scholar : PubMed/NCBI

45 

Ajduković J: HIF-1 - a big chapter in the cancer tale. Exp Oncol. 38:9–12. 2016.PubMed/NCBI

46 

Sajadimajd S, Yazdanparast R and Akram S: Involvement of Numb-mediated HIF-1α inhibition in anti-proliferative effect of PNA-antimiR-182 in trastuzumab-sensitive and -resistant SKBR3 cells. Tumour Biol. 37:5413–5426. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Bao B, Ahmad A, Kong D, Ali S, Azmi AS, Li Y, Banerjee S, Padhye S and Sarkar FH: Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDF. PLoS One. 7:e437262012. View Article : Google Scholar : PubMed/NCBI

48 

Xu H, Zhao L, Fang Q, Sun J, Zhang S, Zhan C, Liu S and Zhang Y: MiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1α. PLoS One. 9:e1155652014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
García-Vázquez R, Gallardo Rincón D, Ruiz-García E, Meneses García A, Hernández De La Cruz ON, Astudillo-De La Vega H, Isla-Ortiz D, Marchat LA, Salinas-Vera YM, Carlos-Reyes Á, Carlos-Reyes Á, et al: let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer. Oncol Rep 39: 3086-3094, 2018.
APA
García-Vázquez, R., Gallardo Rincón, D., Ruiz-García, E., Meneses García, A., Hernández De La Cruz, O.N., Astudillo-De La Vega, H. ... López-Camarillo, C. (2018). let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer. Oncology Reports, 39, 3086-3094. https://doi.org/10.3892/or.2018.6366
MLA
García-Vázquez, R., Gallardo Rincón, D., Ruiz-García, E., Meneses García, A., Hernández De La Cruz, O. N., Astudillo-De La Vega, H., Isla-Ortiz, D., Marchat, L. A., Salinas-Vera, Y. M., Carlos-Reyes, Á., López-González, S., Ramos-Payan, R., López-Camarillo, C."let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer". Oncology Reports 39.6 (2018): 3086-3094.
Chicago
García-Vázquez, R., Gallardo Rincón, D., Ruiz-García, E., Meneses García, A., Hernández De La Cruz, O. N., Astudillo-De La Vega, H., Isla-Ortiz, D., Marchat, L. A., Salinas-Vera, Y. M., Carlos-Reyes, Á., López-González, S., Ramos-Payan, R., López-Camarillo, C."let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer". Oncology Reports 39, no. 6 (2018): 3086-3094. https://doi.org/10.3892/or.2018.6366
Copy and paste a formatted citation
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Spandidos Publications style
García-Vázquez R, Gallardo Rincón D, Ruiz-García E, Meneses García A, Hernández De La Cruz ON, Astudillo-De La Vega H, Isla-Ortiz D, Marchat LA, Salinas-Vera YM, Carlos-Reyes Á, Carlos-Reyes Á, et al: let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer. Oncol Rep 39: 3086-3094, 2018.
APA
García-Vázquez, R., Gallardo Rincón, D., Ruiz-García, E., Meneses García, A., Hernández De La Cruz, O.N., Astudillo-De La Vega, H. ... López-Camarillo, C. (2018). let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer. Oncology Reports, 39, 3086-3094. https://doi.org/10.3892/or.2018.6366
MLA
García-Vázquez, R., Gallardo Rincón, D., Ruiz-García, E., Meneses García, A., Hernández De La Cruz, O. N., Astudillo-De La Vega, H., Isla-Ortiz, D., Marchat, L. A., Salinas-Vera, Y. M., Carlos-Reyes, Á., López-González, S., Ramos-Payan, R., López-Camarillo, C."let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer". Oncology Reports 39.6 (2018): 3086-3094.
Chicago
García-Vázquez, R., Gallardo Rincón, D., Ruiz-García, E., Meneses García, A., Hernández De La Cruz, O. N., Astudillo-De La Vega, H., Isla-Ortiz, D., Marchat, L. A., Salinas-Vera, Y. M., Carlos-Reyes, Á., López-González, S., Ramos-Payan, R., López-Camarillo, C."let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer". Oncology Reports 39, no. 6 (2018): 3086-3094. https://doi.org/10.3892/or.2018.6366
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