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Review

Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)

  • Authors:
    • Shenhe Jin
    • Juying Wei
    • Liangshun You
    • Hui Liu
    • Wenbin Qian
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 2473-2481
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    Published online on: April 13, 2018
       https://doi.org/10.3892/or.2018.6370
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Abstract

Autophagy, a physiological process in which cellular components are degraded by the lysosome for cell homeostasis, plays an important role in cell metabolism, including cell proliferation, differentiation, survival and apoptosis. Recent studies indicate that autophagy serves as a survival mechanism by eliminating misfolded proteins and attenuating DNA damage. Autophagy can also suppress tumor growth, depending upon the cell context and functional status. Dysfunction of autophagy may be closely linked to the initiation and development of various diseases, including hematological malignancies. Mounting evidence highlights the dual role of autophagy in blood cancers through multifarious signal pathways. Therefore, strategies targeting autophagy will develop innovative therapeutic approaches for blood cancers, improve the efficacy of chemotherapy, and bring significant benefits for patients.
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1 

Dong Z, Liang S, Hu J, Jin W, Zhan Q and Zhao K: Autophagy as a target for hematological malignancy therapy. Blood Rev. 30:369–380. 2016. View Article : Google Scholar

2 

Helgason GV, Holyoake TL and Ryan KM: Role of autophagy in cancer prevention, development and therapy. Essays Biochem. 55:133–151. 2013. View Article : Google Scholar

3 

Duffy A, Le J, Sausville E and Emadi A: Autophagy modulation: A target for cancer treatment development. Cancer Chemother Pharmacol. 75:439–447. 2015. View Article : Google Scholar

4 

Klionsky DJ: The molecular machinery of autophagy: Unanswered questions. J Cell Sci. 118:7–18. 2005. View Article : Google Scholar

5 

Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, et al: Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell. 20:1981–1991. 2009. View Article : Google Scholar

6 

Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M and Kim DH: ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 20:1992–2003. 2009. View Article : Google Scholar

7 

Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P and Di Paolo G: Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One. 8:e764052013. View Article : Google Scholar

8 

Petibone DM, Majeed W and Casciano DA: Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity. J Appl Toxicol. 37:23–37. 2017. View Article : Google Scholar

9 

Hamasaki M, Shibutani ST and Yoshimori T: Up-to-date membrane biogenesis in the autophagosome formation. Curr Opin Cell Biol. 25:455–460. 2013. View Article : Google Scholar

10 

Fujita N, Itoh T, Omori H, Fukuda M, Noda T and Yoshimori T: The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell. 19:2092–2100. 2008. View Article : Google Scholar

11 

Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F and Ohsumi Y: The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 282:37298–37302. 2007. View Article : Google Scholar

12 

Geng J and Klionsky DJ: The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein modifications: Beyond the usual suspects’ review series. EMBO Rep. 9:859–864. 2008. View Article : Google Scholar

13 

Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V and Elazar Z: LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J. 29:1792–1802. 2010. View Article : Google Scholar

14 

Chua CE, Gan BQ and Tang BL: Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation. Cell Mol Life Sci. 68:3349–3358. 2011. View Article : Google Scholar

15 

Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, et al: Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 10:776–787. 2008. View Article : Google Scholar

16 

Pan H, Chen L, Xu Y, Han W, Lou F, Fei W, Liu S, Jing Z and Sui X: Autophagy-associated immune responses and cancer immunotherapy. Oncotarget. 7:21235–21246. 2016.

17 

Stellrecht CM, Vangapandu HV, Le XF, Mao W and Shentu S: ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 7:232014. View Article : Google Scholar

18 

Baehrecke EH: Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol. 6:505–510. 2005. View Article : Google Scholar

19 

Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 23:2891–2906. 2004. View Article : Google Scholar

20 

Bursch W: The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ. 8:569–581. 2001. View Article : Google Scholar

21 

Lin L and Baehrecke EH: Autophagy, cell death, and cancer. Mol Cell Oncol. 2:e9859132015. View Article : Google Scholar

22 

Scott RC, Juhász G and Neufeld TP: Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 17:1–11. 2007. View Article : Google Scholar

23 

Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH and Lenardo M: Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci USA. 103:4952–4957. 2006. View Article : Google Scholar

24 

Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH and Stenmark H: Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol. 190:523–531. 2010. View Article : Google Scholar

25 

Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ and Codogno P: Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem. 275:992–998. 2000. View Article : Google Scholar

26 

Hanada M, Feng J and Hemmings BA: Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim Biophys Acta. 1697:3–16. 2004. View Article : Google Scholar

27 

Yu X, Long YC and Shen HM: Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy. Autophagy. 11:1711–1728. 2015. View Article : Google Scholar

28 

McKnight NC and Zhenyu Y: Beclin 1, an essential component and master regulator of PI3K-III in health and disease. Curr Pathobiol Rep. 1:231–238. 2013. View Article : Google Scholar

29 

Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, et al: Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol. 25:1025–1040. 2005. View Article : Google Scholar

30 

Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, et al: Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol. 26:9220–9231. 2006. View Article : Google Scholar

31 

Moretti L, Yang ES, Kim KW and Lu B: Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist Updat. 10:135–143. 2007. View Article : Google Scholar

32 

Ron D: Translational control in the endoplasmic reticulum stress response. J Clin Invest. 110:1383–1388. 2002. View Article : Google Scholar

33 

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE and Shaw RJ: AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 30:214–226. 2008. View Article : Google Scholar

34 

Schmukler E, Kloog Y and Pinkas-Kramarski R: Ras and autophagy in cancer development and therapy. Oncotarget. 5:577–586. 2014. View Article : Google Scholar

35 

Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 3:11–22. 2003. View Article : Google Scholar

36 

Byun JY, Yoon CH, An S, Park IC, Kang CM, Kim MJ and Lee SJ: The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras. Carcinogenesis. 30:1880–1888. 2009. View Article : Google Scholar

37 

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD and Levine B: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122:927–939. 2005. View Article : Google Scholar

38 

Levine B, Sinha SC and Kroemer G: Bcl-2 family members: Dual regulators of apoptosis and autophagy. Autophagy. 4:600–606. 2008. View Article : Google Scholar

39 

Inbal B, Bialik S, Sabanay I, Shani G and Kimchi A: DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol. 157:455–468. 2002. View Article : Google Scholar

40 

Zeng X, Yan T, Schupp JE, Seo Y and Kinsella TJ: DNA mismatch repair initiates 6-thioguanine-induced autophagy through p53 activation in human tumor cells. Clin Cancer Res. 13:1315–1321. 2007. View Article : Google Scholar

41 

Auberger P and Puissant A: Autophagy, a key mechanism of oncogenesis and resistance in leukemia. Blood. 129:547–552. 2017. View Article : Google Scholar

42 

Liu T, Zhang Z, Yu C, Zeng C, Xu X, Wu G, Huang Z and Li W: Tetrandrine antagonizes acute megakaryoblastic leukemia growth by forcing autophagy-mediated differentiation. Br J Pharmacol. 174:4308–4328. 2017. View Article : Google Scholar

43 

Schläfli AM, Isakson P, Garattini E, Simonsen A and Tschan MP: The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells. Sci Rep. 7:129802017. View Article : Google Scholar

44 

Pierdominici M, Barbati C, Vomero M, Locatelli SL, Carlo-Stella C, Ortona E and Malorni W: Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders. FASEB J. 28:524–535. 2014. View Article : Google Scholar

45 

Zhang H, Pang Y, Ma C, Li J, Wang H and Shao Z: ClC5 decreases the sensitivity of multiple myeloma cells to bortezomib via promoting pro-survival autophagy. Oncol Res. Sep 11–2017.(Epub ahead of print). doi: 10.3727/096504017X15049221237147. View Article : Google Scholar

46 

Yun Z, Zhichao J, Hao Y, Ou J, Ran Y, Wen D and Qun S: Targeting autophagy in multiple myeloma. Leuk Res. 59:97–104. 2017. View Article : Google Scholar

47 

Mahoney E, Lucas DM, Gupta SV, Wagner AJ, Herman SE, Smith LL, Yeh YY, Andritsos L, Jones JA, Flynn JM, et al: ER stress and autophagy: New discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. Blood. 120:1262–1273. 2012. View Article : Google Scholar

48 

Sharma A, Singh K, Mazumder S, Hill BT, Kalaycio M and Almasan A: BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells. Cell Death Dis. 4:e6282013. View Article : Google Scholar

49 

Zakikhani M, Dowling RJ, Sonenberg N and Pollak MN: The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res. 1:369–375. 2008. View Article : Google Scholar

50 

Wang LW, Li ZS, Zou DW, Jin ZD, Gao J and Xu GM: Metformin induces apoptosis of pancreatic cancer cells. World J Gastroenterol. 14:7192–7198. 2008. View Article : Google Scholar

51 

Wang F, Liu Z, Zeng J, Zhu H, Li J, Cheng X, Jiang T, Zhang L, Zhang C, Chen T, et al: Metformin synergistically sensitizes FLT3-ITD-positive acute myeloid leukemia to sorafenib by promoting mTOR-mediated apoptosis and autophagy. Leuk Res. 39:1421–1427. 2015. View Article : Google Scholar

52 

Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, Chen SJ, Chen Y and Zhao WL: Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis. 3:e2752012. View Article : Google Scholar

53 

Xia D, Zhang YT, Xu GP, Yan WW, Pan XR and Tong JH: Sertraline exerts its antitumor functions through both apoptosis and autophagy pathways in acute myeloid leukemia cells. Leuk Lymphoma. 58:1–10. 2017. View Article : Google Scholar

54 

Trocoli A, Mathieu J, Priault M, Reiffers J, Souquère S, Pierron G, Besançon F and Djavaheri-Mergny M: ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells. Autophagy. 7:1108–1114. 2011. View Article : Google Scholar

55 

Nishioka C, Ikezoe T, Yang J, Gery S, Koeffler HP and Yokoyama A: Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells. Int J Cancer. 125:1710–1720. 2009. View Article : Google Scholar

56 

Isakson P, Bjørås M, Bøe SO and Simonsen A: Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood. 116:2324–2331. 2010. View Article : Google Scholar

57 

Eriksen AB, Torgersen ML, Holm KL, Abrahamsen G, Spurkland A, Moskaug JØ, Simonsen A and Blomhoff HK: Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy. Autophagy. 11:460–471. 2015. View Article : Google Scholar

58 

Qian W, Liu J, Jin J, Ni W and Xu W: Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk Res. 31:329–339. 2007. View Article : Google Scholar

59 

Goussetis DJ, Altman JK, Glaser H, McNeer JL, Tallman MS and Platanias LC: Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. J Biol Chem. 285:29989–29997. 2010. View Article : Google Scholar

60 

Ristic B, Bosnjak M, Arsikin K, Mircic A, Suzin-Zivkovic V, Bogdanovic A, Perovic V, Martinovic T, Kravic-Stevovic T, Bumbasirevic V, et al: Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells. Exp Cell Res. 326:90–102. 2014. View Article : Google Scholar

61 

Grandér D, Kharaziha P, Laane E, Pokrovskaja K and Panaretakis T: Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies. Autophagy. 5:1198–1200. 2009. View Article : Google Scholar

62 

Laane E, Tamm KP, Buentke E, Ito K, Kharaziha P, Oscarsson J, Corcoran M, Björklund AC, Hultenby K, Lundin J, et al: Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16:1018–1029. 2009. View Article : Google Scholar

63 

Granato M, Chiozzi B, Filardi MR, Lotti LV, Di Renzo L, Faggioni A and Cirone M: Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells. Cancer Lett. 366:191–197. 2015. View Article : Google Scholar

64 

Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS, Opferman JT and Slack RS: MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO J. 30:395–407. 2011. View Article : Google Scholar

65 

Granato M, Lacconi V, Peddis M, Lotti LV, Di Renzo L, Gonnella R, Santarelli R, Trivedi P, Frati L, D'Orazi G, et al: HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma. Cell Death Dis. 4:e7302013. View Article : Google Scholar

66 

Crowley LC, Elzinga BM, O'Sullivan GC and McKenna SL: Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment. Am J Hematol. 86:38–47. 2011. View Article : Google Scholar

67 

Rothe K, Lin H, Lin KB, Leung A, Wang HM, Malekesmaeili M, Brinkman RR, Forrest DL, Gorski SM and Jiang X: The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells. Blood. 123:3622–3634. 2014. View Article : Google Scholar

68 

Mancini M, Leo E, Campi V, Castagnetti F, Zazzeroni L, Gugliotta G, Santucci MA and Martinelli G: A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib. Cell Signal. 26:1690–1697. 2014. View Article : Google Scholar

69 

Sheng Z, Ma L, Sun JE, Zhu LJ and Green MR: BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood. 118:2840–2848. 2011. View Article : Google Scholar

70 

Xin P, Li C, Zheng Y, Peng Q, Xiao H, Huang Y and Zhu X: Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines. Drug Des Devel Ther. 11:1115–1126. 2017. View Article : Google Scholar

71 

Elzinga BM, Nyhan MJ, Crowley LC, O'Donovan TR, Cahill MR and McKenna SL: Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein. Am J Hematol. 88:455–462. 2013. View Article : Google Scholar

72 

Zhu S, Cao L, Yu Y, Yang L, Yang M, Liu K, Huang J, Kang R, Livesey KM and Tang D: Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells. Autophagy. 9:317–327. 2013. View Article : Google Scholar

73 

Bosnjak M, Ristic B, Arsikin K, Mircic A, Suzin-Zivkovic V, Perovic V, Bogdanovic A, Paunovic V, Markovic I, Bumbasirevic V, et al: Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death. PLoS One. 9:e943742014. View Article : Google Scholar

74 

Pan Y, Gao Y, Chen L, Gao G, Dong H, Yang Y, Dong B and Chen X: Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy. Clin Cancer Res. 17:3248–3258. 2011. View Article : Google Scholar

75 

Wang Z, Zhu S, Zhang G and Liu S: Inhibition of autophagy enhances the anticancer activity of bortezomib in B-cell acute lymphoblastic leukemia cells. Am J Cancer Res. 5:639–650. 2015.

76 

Granato M, Santarelli R, Lotti LV, Di Renzo L, Gonnella R, Garufi A, Trivedi P, Frati L, D'Orazi G, Faggioni A, et al: JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells. PLoS One. 8:e759652013. View Article : Google Scholar

77 

Han W, Sun J, Feng L, Wang K, Li D, Pan Q, Chen Y, Jin W, Wang X, Pan H, et al: Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS One. 6:e284912011. View Article : Google Scholar

78 

Marignac Martinez VL, Smith S, Toban N, Bazile M and Aloyz R: Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming. Oncotarget. 4:2550–2566. 2013.

79 

Morita M, Nishinaka Y, Kato I, Saida S, Hiramatsu H, Kamikubo Y, Heike T, Nakahata T and Adachi S: Dasatinib induces autophagy in mice with Bcr-Abl-positive leukemia. Int J Hematol. 105:335–340. 2017. View Article : Google Scholar

80 

Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, Kokaraki G, Panzar M, Laane E, Osterborg A, et al: Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model. Cancer Res. 72:5348–5362. 2012. View Article : Google Scholar

81 

Takahashi H, Inoue J, Sakaguchi K, Takagi M, Mizutani S and Inazawa J: Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells. Oncogene. 36:4267–4276. 2017. View Article : Google Scholar

82 

Schnekenburger M, Grandjenette C, Ghelfi J, Karius T, Foliguet B, Dicato M and Diederich M: Sustained exposure to the DNA demethylating agent, 2-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy. Biochem Pharmacol. 81:364–378. 2011. View Article : Google Scholar

83 

Romano A, Giallongo C, La Cava P, Parrinello NL, Chiechi A, Vetro C, Tibullo D, Di Raimondo F, Liotta LA, Espina V, et al: Proteomic analysis reveals autophagy as pro-survival pathway elicited by long-term exposure with 5-azacitidine in high-risk myelodysplasia. Front Pharmacol. 8:2042017. View Article : Google Scholar

84 

Evangelisti C, Evangelisti C, Chiarini F, Lonetti A, Buontempo F, Neri LM, McCubrey JA and Martelli AM: Autophagy in acute leukemias: A double-edged sword with important therapeutic implications. Biochim Biophys Acta. 1853:14–26. 2015. View Article : Google Scholar

85 

Ekiz HA, Can G and Baran Y: Role of autophagy in the progression and suppression of leukemias. Crit Rev Oncol Hematol. 81:275–285. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jin S, Wei J, You L, Liu H and Qian W: Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review). Oncol Rep 39: 2473-2481, 2018.
APA
Jin, S., Wei, J., You, L., Liu, H., & Qian, W. (2018). Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review). Oncology Reports, 39, 2473-2481. https://doi.org/10.3892/or.2018.6370
MLA
Jin, S., Wei, J., You, L., Liu, H., Qian, W."Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)". Oncology Reports 39.6 (2018): 2473-2481.
Chicago
Jin, S., Wei, J., You, L., Liu, H., Qian, W."Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)". Oncology Reports 39, no. 6 (2018): 2473-2481. https://doi.org/10.3892/or.2018.6370
Copy and paste a formatted citation
x
Spandidos Publications style
Jin S, Wei J, You L, Liu H and Qian W: Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review). Oncol Rep 39: 2473-2481, 2018.
APA
Jin, S., Wei, J., You, L., Liu, H., & Qian, W. (2018). Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review). Oncology Reports, 39, 2473-2481. https://doi.org/10.3892/or.2018.6370
MLA
Jin, S., Wei, J., You, L., Liu, H., Qian, W."Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)". Oncology Reports 39.6 (2018): 2473-2481.
Chicago
Jin, S., Wei, J., You, L., Liu, H., Qian, W."Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)". Oncology Reports 39, no. 6 (2018): 2473-2481. https://doi.org/10.3892/or.2018.6370
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