Open Access

KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells

  • Authors:
    • Yosuke Kawai
    • Kiyosumi Shibata
    • Jun Sakata
    • Shiro Suzuki
    • Fumi Utsumi
    • Kaoru Niimi
    • Ryuichiro Sekiya
    • Takeshi Senga
    • Fumitaka Kikkawa
    • Hiroaki Kajiyama
  • View Affiliations

  • Published online on: April 25, 2018     https://doi.org/10.3892/or.2018.6401
  • Pages: 195-205
  • Copyright: © Kawai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Kinesin family member 20A (KIF20A), which is involved in cytokinesis and intracellular transportation, has been recently reported to be upregulated in several malignancies and may contribute to chemotherapeutic resistance. We examined the distribution and expression of KIF20A in clear‑cell carcinoma (CCC) of the ovary to elucidate its clinical significance and molecular mechanism. Paraffin sections from ovarian CCC tissues (N=43) were immunostained with KIF20A antibody, and the staining intensities were semi‑quantitatively evaluated. Furthermore, we investigated whether silencing of KIF20A contributes to the proliferation‑inhibitory potential using CCC cells. During the observational period, 18 patients (41.9%) developed recurrence. The median time to recurrence was 11.5 months. Patients in the high KIF20A expression group showed poorer progression‑free survival (PFS) and overall survival (OS) than those in the low expression group (P=0.0443 and P=0.0478, respectively). In multivariable analyses, KIF20A expression was also a significantly independent indicator of PFS and a marginally significant indicator of OS [PFS: HR (high vs. low), 5.488; 95% CI, 1.410‑24.772 (P=0.0136); OS: HR, 2.835; 95% CI, 0.854‑11.035, (P=0.0897)]. In in vitro studies, the ovarian CCC cell proliferation was significantly decreased by KIF20A silencing or in the presence of KIF20A inhibitor in CCC cells. Cell cycle G2/M arrest and a higher apoptosis‑induced fraction were more frequently observed in si‑KIF20A‑transfected CCC cells than in the control cells. Although the present study was preliminary, these data indicate the possible involvement of KIF20A in the proliferation of CCC, suggesting that targeting this molecule may contribute to reversing the malignant potential consequently affecting the oncologic outcome of CCC patients.
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July-2018
Volume 40 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kawai Y, Shibata K, Sakata J, Suzuki S, Utsumi F, Niimi K, Sekiya R, Senga T, Kikkawa F, Kajiyama H, Kajiyama H, et al: KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells. Oncol Rep 40: 195-205, 2018
APA
Kawai, Y., Shibata, K., Sakata, J., Suzuki, S., Utsumi, F., Niimi, K. ... Kajiyama, H. (2018). KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells. Oncology Reports, 40, 195-205. https://doi.org/10.3892/or.2018.6401
MLA
Kawai, Y., Shibata, K., Sakata, J., Suzuki, S., Utsumi, F., Niimi, K., Sekiya, R., Senga, T., Kikkawa, F., Kajiyama, H."KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells". Oncology Reports 40.1 (2018): 195-205.
Chicago
Kawai, Y., Shibata, K., Sakata, J., Suzuki, S., Utsumi, F., Niimi, K., Sekiya, R., Senga, T., Kikkawa, F., Kajiyama, H."KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells". Oncology Reports 40, no. 1 (2018): 195-205. https://doi.org/10.3892/or.2018.6401