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Article

Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation

  • Authors:
    • Koji Harada
    • Tarannum Ferdous
    • Yoichi Mizukami
    • Katsuaki Mishima
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755‑8505, Japan, Center for Gene Research, Yamaguchi University, Ube, Yamaguchi 755‑8505, Japan
  • Pages: 361-368
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/or.2018.6440
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Abstract

An elemental diet (ED) has been reported to reduce oral mucositis and dermatitis induced by chemotherapy. However, its molecular mechanism of action as an anti‑inflammatory agent is still unknown. The aim of the present study was to clarify whether ED confers its anti‑inflammatory action via reduction of pro‑inflammatory cytokine production in keratinocytes in vivo and in vitro. We evaluated the efficacy of ED in the treatment of 5‑fluorouracil (5‑FU)‑induced dermatitis of nude mice, and examined the expression of pro‑inflammatory cytokines such as tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6 using immunohistochemistry. Moreover, we assessed the expression and production of these pro‑inflammatory cytokines by western blotting and ELISA assays, respectively, in immortalized human keratinocyte cell line, HaCaT. Furthermore, we investigated the effect of ED on a major inflammation‑related factor, nuclear transcription factor‑κB (NF‑κB), since it controls many genes involved in the inflammation pathway. Our results indicated that ED reduced the expression of TNF‑α, IL‑1β and IL‑6. It also inhibited the nuclear transition of p65 NF‑κB, which is known to regulate inflammatory cytokine expression in keratinocytes suffering from 5‑FU‑induced dermatitis. In addition, ED reduced the production of TNF‑α, IL‑1β and IL‑6 in HaCaT cells. Moreover, ED attenuated 5‑FU‑induced transcriptional activation of NF‑κB. These findings revealed that ED suppresses the expression of pro‑inflammatory cytokines by suppressing NF‑κB in keratinocytes, suggesting the potential usefulness of ED in the treatment of various inflammatory diseases of the dermal region.
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1 

Burdelya LG, Gleiberman AS, Toshkov I, Aygun-Sunar S, Bapardekar M, Manderscheid-Kern P, Bellnier D, Krivokrysenko VI, Feinstein E, Feinstein E and Gudkov AV: Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: Implications for head-and-neck cancer radiotherapy. Int J Radiat Oncol Biol Phys. 83:228–234. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Imai T, Matsuura K, Asada Y, Sagai S, Katagiri K, Ishida E, Saito D, Sadayasu R, Wada H and Saijo S: Effect of HMB/Arg/Gln on the prevention of radiation dermatitis in head and neck cancer patients treated with concurrent chemoradiotherapy. Jpn J Clin Oncol. 44:422–427. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Habl G, Potthoff K, Haefner MF, Abdollahi A, Hassel JC, Boller E, Indorf M and Debus J: Differentiation of irradiation and cetuximab induced skin reactions in patients with locally advanced head and neck cancer undergoing radioimmunotherapy: the HICARE protocol (head and neck cancer: Immunochemo and radiotherapy with erbitux)-a multicenter phase IV trial. BMC Cancer. 13:3452013. View Article : Google Scholar : PubMed/NCBI

4 

Sonis ST: Oral mucositis. Anticancer Drugs. 22:607–612. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Miyano K, Ueno T, Yatsuoka W and Uezono Y: Treatment for Cancer Patients with Oral Mucositis: Assessment based on the mucositis study group of the multinational association of supportive care in cancer in international society of oral oncology (MASCC/ISOO) in 2013 and proposal of possible novel treatment with a Japanese herbal medicine. Curr Pharm Des. 22:2270–2278. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Lalla RV, Sonis ST and Peterson DE: Management of oral mucositis in patients who have cancer. Dent Clin North Am. 52(61–77): viii2008.

7 

Skubitz KM: Glutamine as a potential treatment for the prevention of chemotherapy induced mucositis. J Infusional Chemotherapy. 4:64–67. 1994.

8 

Kyllo RL and Anadkat MJ: Dermatologic adverse events to chemotherapeutic agents, part 1: Cytotoxics, epidermal growth factor receptors, multikinase inhibitors, and proteasome inhibitors. Semin Cutan Med Surg. 33:28–39. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Shou J, Lieberman MD, Hofmann K, Leon P, Redmond HP, Davies H and Daly JM: Dietary manipulation of methotrexate-induced enterocolitis. J Parenter Enteral Nutr. 15:307–312. 1991. View Article : Google Scholar

10 

Zhang M, Zhou J, Wang L, Li B, Guo J, Guan X, Han Q and Zhang H: Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-α), IL-6 and IL-1β levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice. Biol Pharm Bull. 37:347–354. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zhu J, Luo C, Wang P, He Q, Zhou J and Peng H: Saikosaponin A mediates the inflammatory response by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells. Exp Ther Med. 5:1345–1350. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Barnes PJ and Karin M: Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 336:1066–1071. 1997. View Article : Google Scholar : PubMed/NCBI

13 

McCarthy GM, Awde JD, Ghandi H, Vincent M and Kocha WI: Risk factors associated with mucositis in cancer patients receiving 5-fluorouracil. Oral Oncol. 34:484–490. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD and Peterson DE: Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology: Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. 109:820–831. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Peterson DE, Bensadoun RJ and Roila F: ESMO Guidelines Working Group: Management of oral and gastrointestinal mucositis: ESMO clinical recommendations. Ann Oncol. 20 Suppl 4:S174–S177. 2009. View Article : Google Scholar

16 

Quinn B, Potting CM, Stone R, Blijlevens NM, Fliedner M, Margulies A and Sharp L: Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplantation patients. Eur J Cancer. 44:61–72. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Henke M, Alfonsi M, Foa P, Giralt J, Bardet E, Cerezo L, Salzwimmer M, Lizambri R, Emmerson L, Chen MG and Berger D: Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: A randomized, placebo-controlled trial. J Clin Oncol. 29:2815–2820. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Bensinger W, Schubert M, Ang KK, Brizel D, Brown E, Eilers JG, Elting L, Mittal BB, Schattner MA, Spielberger R, et al: NCCN Task Force Report. Prevention and management of mucositis in cancer care. J Natl Compr Canc Netw. 6 Suppl 1:S1–S21; quiz S22-S24. 2008.PubMed/NCBI

19 

Svanberg A, Ohrn K and Birgegard G: Oral cryotherapy reduces mucositis and improves nutrition-a randomised controlled trial. J Clin Nurs. 19:2146–2151. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Scully C, Epstein J and Sonis S: Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 2: Diagnosis and management of mucositis. Head Neck. 26:77–84. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Cowen D, Tardieu C, Schubert M, Peterson D, Resbeut M, Faucher C and Franquin JC: Low energy Helium-Neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: Results of a double blind randomized trial. Int J Radiat Oncol Biol Phys. 38:697–703. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Online EA Pharma Co., . Ltd Products Information, Elental®. http://www.eapharma.co.jp/medicalexpert/product/elental/elental_information.htmlWebpage in Japanese. 19–August. 2017

23 

Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T and Matsumoto K: Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: Cytokine production and endoscopic and histological findings. Inflamm Bowel Dis. 11:580–588. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Hanai H, Iida T, Takeuchi K, Arai H, Arai O, Abe J, Tanaka T, Maruyama Y, Ikeya K, Sugimoto K, et al: Nutritional therapy versus 6-mercaptopurine as maintenance therapy in patients with Crohn's disease. Dig Liver Dis. 44:649–654. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Johtatsu T, Andoh A, Kurihara M, Iwakawa H, Tsujikawa T, Kashiwagi A, Fujiyama Y and Sasaki M: Serum concentrations of trace elements in patients with Crohn's disease receiving enteral nutrition. J Clin Biochem Nutr. 41:197–201. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Yamamoto T, Nakahigashi M, Saniabadi AR, Iwata T, Maruyama Y, Umegae S and Matsumoto K: Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn's disease: A prospective study. Inflamm Bowel Dis. 13:1493–1501. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T and Matsumoto K: Impact of long-term enteral nutrition on clinical and endoscopic recurrence after resection for Crohn's disease: A prospective, non-randomized, parallel, controlled study. Aliment Pharmacol Ther. 25:67–72. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Fukui T, Itoh Y, Orihara M, Yoshizawa K, Takeda H, Kawada S and Yoshioka T: Elental prevented and reduced oral mucositis during chemotherapy in patients esophageal cancer. Gan To Kagaku Ryoh. 38:2597–2601. 2011.(In Japanese).

29 

Ogata Y, Takeuchi M, Ishibashi N, Kibe S, Takahashi K, Uchida S, Murakami N, Yahara T and Shirouzu K: Efficacy of Elental on prevention for chemotherapy-induced oral mucositis in colorectal cancer patients. Gan To Kagaku Ryoho. 39:583–587. 2012.(In Japanese). PubMed/NCBI

30 

Harada K, Ferdous T, Horinaga D, Uchida K, Mano T, Mishima K, Park S, Hanazawa H, Takahashi S, Okita A, et al: Efficacy of elemental diet on prevention for chemoradiotherapy-induced oral mucositis in patients with oral squamous cell carcinoma. Support Care Cancer. 24:953–959. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Harada K, Ferdous T, Kobayashi H and Ueyama Y: Elemental diet accelerates the recovery from oral mucositis and dermatitis induced by 5-fluorouracil through the induction of fibroblast growth factor 2. Integr Cancer Ther. July 1–2017.(Epub ahead of print). PubMed/NCBI

32 

O'Dwyer ST, Scott T, Smith RJ and Wilmore DW: 5-fluorouracil toxicity on small intestinal mucosa but not white blood cells is decreased by glutamine. Clin Res. 35:367A1987.

33 

Carneiro-Filho BA, Oriá RB, Rea Wood K, Brito GA, Fujii J, Obrig T, Lima AA and Guerrant RL: Alanyl-glutamine hastens morphologic recovery from 5-fluorouracil-induced mucositis in mice. Nutrition. 20:934–941. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA, Brenner DA and Rhoads JM: L-glutamine and l-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Am J physiol. 269:G591–G599. 1995.PubMed/NCBI

35 

Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM and Brenner DA: L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am J Physiol. 272:G943–G953. 1997.PubMed/NCBI

36 

Hong RW, Rounds JD, Helton WS, Robinson MK and Wilmore DW: Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg. 215:114–119. 1992. View Article : Google Scholar : PubMed/NCBI

37 

Denno R, Rounds JD, Faris R, Holejko LB and Wilmore DW: Glutamine-enriched total parenteral nutrition enhances plasma glutathione in the resting state. J Surg Res. 61:35–38. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Zhou BR, Zhang JA, Zhang Q, Permatasari F, Xu Y, Wu D, Yin ZQ and Luo D: Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1β, and tumor necrosis factor-α via a NF-κB-dependent mechanism in HaCaT keratinocytes. Mediators Inflamm. 2013:5304292013. View Article : Google Scholar : PubMed/NCBI

39 

Baud V and Karin M: Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 8:33–40. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Yamamoto Y and Gaynor RB: Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest. 107:135–142. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Harada K, Ferdous T, Mizukami Y and Mishima K: Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation. Oncol Rep 40: 361-368, 2018.
APA
Harada, K., Ferdous, T., Mizukami, Y., & Mishima, K. (2018). Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation. Oncology Reports, 40, 361-368. https://doi.org/10.3892/or.2018.6440
MLA
Harada, K., Ferdous, T., Mizukami, Y., Mishima, K."Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation". Oncology Reports 40.1 (2018): 361-368.
Chicago
Harada, K., Ferdous, T., Mizukami, Y., Mishima, K."Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation". Oncology Reports 40, no. 1 (2018): 361-368. https://doi.org/10.3892/or.2018.6440
Copy and paste a formatted citation
x
Spandidos Publications style
Harada K, Ferdous T, Mizukami Y and Mishima K: Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation. Oncol Rep 40: 361-368, 2018.
APA
Harada, K., Ferdous, T., Mizukami, Y., & Mishima, K. (2018). Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation. Oncology Reports, 40, 361-368. https://doi.org/10.3892/or.2018.6440
MLA
Harada, K., Ferdous, T., Mizukami, Y., Mishima, K."Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation". Oncology Reports 40.1 (2018): 361-368.
Chicago
Harada, K., Ferdous, T., Mizukami, Y., Mishima, K."Elemental diet inhibits pro‑inflammatory cytokine production in keratinocytes through the suppression of NF‑κB activation". Oncology Reports 40, no. 1 (2018): 361-368. https://doi.org/10.3892/or.2018.6440
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