|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Sarode GS, Sarode SC, Maniyar N, Anand R
and Patil S: Oral cancer databases: A comprehensive review. J Oral
Pathol Med. 2017. View Article : Google Scholar :
|
|
3
|
Gharat SA, Momin M and Bhavsar C: Oral
squamous cell carcinoma: Current treatment strategies and
nanotechnology-based approaches for prevention and therapy. Crit
Rev Ther Drug Carrier Syst. 33:363–400. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Mizushima N, Yoshimori T and Ohsumi Y: The
role of Atg proteins in autophagosome formation. Annu Rev Cell Dev
Biol. 27:107–132. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
White E, Mehnert JM and Chan CS:
Autophagy, metabolism, and cancer. Clin Cancer Res. 21:5037–5046.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lorin S, Hamai A, Mehrpour M and Codogno
P: Autophagy regulation and its role in cancer. Semin Cancer Biol.
23:361–379. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Jiang X, Overholtzer M and Thompson CB:
Autophagy in cellular metabolism and cancer. J Clin Invest.
125:47–54. 2015. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Villar VH, Merhi F, Djavaheri-Mergny M and
Duran RV: Glutaminolysis and autophagy in cancer. Autophagy.
11:1198–1208. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Kumar A, Singh UK and Chaudhary A:
Targeting autophagy to overcome drug resistance in cancer therapy.
Future Med Chem. 7:1535–1542. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Huang Z, Zhou L, Chen Z, Nice EC and Huang
C: Stress management by autophagy: Implications for
chemoresistance. Int J Cancer. 139:23–32. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Gomes LR, Vessoni AT and Menck CFM:
Microenvironment and autophagy cross-talk: Implications in cancer
therapy. Pharmacol Res. 107:300–307. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Su Z, Yang Z, Xu Y, Chen Y and Yu Q:
Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol
Cancer. 14:482015. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Mowers EE, Sharifi MN and Macleod KF:
Autophagy in cancer metastasis. Oncogene. 36:1619–1630. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Marcucci F, Ghezzi P and Rumio C: The role
of autophagy in the cross-talk between epithelial-mesenchymal
transitioned tumor cells and cancer stem-like cells. Mol Cancer.
16:32017. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Yasuhara N and Kumar PK: Aptamers that
bind specifically to human KPNA2 (importin-α1) and efficiently
interfere with nuclear transport. J Biochem. 160:259–268. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Christiansen A and Dyrskjøt L: The
functional role of the novel biomarker karyopherin α 2 (KPNA2) in
cancer. Cancer Lett. 331:18–23. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Teng SC, Wu KJ, Tseng SF, Wong CW and Kao
L: Importin KPNA2, NBS1, DNA repair and tumorigenesis. J Mol
Histol. 37:293–299. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Gao Li, Yu L, Li CM, Li Y, Jia BL and
Zhang B: Karyopherin α2 induces apoptosis in tongue squamous cell
carcinoma CAL-27 cells through the p53 pathway. Oncol Rep.
35:3357–3362. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wang CI, Chien KY, Wang CL, Liu HP, Cheng
CC, Chang YS, Yu JS and Yu CJ: Quantitative proteomics reveals
regulation of karyopherin subunit alpha-2 (KPNA2) and its potential
novel cargo proteins in nonsmall cell lung cancer. Mol Cell
Proteomics. 11:1105–1122. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Gluz O, Wild P, Meiler R, Frick M, Ting E,
Mohrmann S, Schuett G, Dahl E, Fuchs T, Herr A, et al: Nuclear
karyopherin alpha2 expression predicts poor survival in patients
with advanced breast cancer irrespective of treatment intensity.
Int J Cancer. 123:1433–1438. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Sakai M, Sohda M, Miyazaki T, Suzuki S,
Sano A, Tanaka N, Inose T, Nakajima M, Kato H and Kuwano H:
Significance of karyopherin-{alpha} 2 (KPNA2) expression in
esophageal squamous cell carcinoma. Anticancer Res. 30:851–856.
2010.PubMed/NCBI
|
|
22
|
Mortezavi A, Hermanns T, Seifert HH,
Baumgartner MK, Provenzano M, Sulser T, Burger M, Montani M,
Ikenberg K, Hofstädter F, et al: KPNA2 expression is an independent
adverse predictor of biochemical recurrence after radical
prostatectomy. Clin Cancer Res. 17:1111–1121. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Noetzel E, Rose M, Bornemann J, Gajewski
M, Knüchel R and Dahl E: Nuclear transport receptor
karyopherin-alpha2 promotes malignant breast cancer phenotypes in
vitro. Oncogene. 31:2101–2114. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Huang L, Wang HY, Li JD, Wang JH, Zhou Y,
Luo RZ, Yun JP, Zhang Y, Jia WH and Zheng M: KPNA2 promotes cell
proliferation and tumorigenicity in epithelial ovarian carcinoma
through upregulation of c-Myc and downregulation of FOXO3a. Cell
Death Dis. 4:e7452013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Rezabakhsh A, Ahmadi M, Khaksar M,
Montaseri A, Malekinejad H, Rahbarghazi R and Garjani A: Rapamycin
inhibits oxidative/nitrosative stress and enhances angiogenesis in
high glucose-treated human umbilical vein endothelial cells: Role
of autophagy. Biomed Pharmacother. 93:885–894. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Ko JH, Yoon SO, Lee HJ and Oh JY:
Rapamycin regulates macrophage activation by inhibiting NLRP3
inflammasome-p38 MAPK-NFkappaB pathways in autophagy- and
p62-dependent manners. Oncotarget. 8:40817–40831. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Xu Z, Huang CM, Shao Z, Zhao XP, Wang M,
Yan TL, Zhou XC, Jiang EH, Ke Liu and Shang ZJ: Autophagy induced
by areca nut extract contributes to decreasing cisplatin toxicity
in oral squamous cell carcinoma cells: Roles of reactive oxygen
species/AMPK signaling. Int J Mol Sci. 18:E5242017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Jia L, Wang J, Wu T, Wu J, Ling J and
Cheng B: In vitro and in vivo antitumor effects of
chloroquine on oral squamous cell carcinoma. Mol Med Rep.
16:5779–5786. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Alshareeda AT, Negm OH, Green AR, Nolan
CC, Tighe P, Albarakati N, Sultana R, Madhusudan S, Ellis IO and
Rakha EA: KPNA2 is a nuclear export protein that contributes to
aberrant localisation of key proteins and poor prognosis of breast
cancer. Br J Cancer. 112:1929–1937. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Altan B, Yokobori T, Mochiki E, Ohno T,
Ogata K, Ogawa A, Yanai M, Kobayashi T, Luvsandagva B, Asao T and
Kuwano H: Nuclear karyopherin-alpha2 expression in primary lesions
and metastatic lymph nodes was associated with poor prognosis and
progression in gastric cancer. Carcinogenesis. 34:2314–2321. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Huang L, Zhou Y, Cao XP, Lin JX, Zhang L,
Huang ST and Zheng M: KPNA2 is a potential diagnostic serum
biomarker for epithelial ovarian cancer and correlates with poor
prognosis. Tumour Biol. 39:10104283177062892017. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Zhou LN, Tan Y, Li P, Zeng P, Chen MB, Ye
Tian and Zhu YQ: Prognostic value of increased KPNA2 expression in
some solid tumors: A systematic review and meta-analysis.
Oncotarget. 8:303–314. 2017.PubMed/NCBI
|
|
33
|
Wang CI, Wang CL, Wang CW, Chen CD, Wu CC,
Liang Y, Tsai YH, Chang YS, Yu JS and Yu CJ: Importin subunit
alpha-2 is identified as a potential biomarker for non-small cell
lung cancer by integration of the cancer cell secretome and tissue
transcriptome. Int J Cancer. 128:2364–2372. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Tsai MM, Huang HW, Wang CS, Lee KF, Tsai
CY, Lu PH, Chi HC, Lin YH, Kuo LM and Lin KH: MicroRNA-26b inhibits
tumor metastasis by targeting the KPNA2/c-jun pathway in human
gastric cancer. Oncotarget. 7:39511–39526. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Buchser WJ, Laskow TC, Pavlik PJ, Lin HM
and Lotze MT: Cell-mediated autophagy promotes cancer cell
survival. Cancer Res. 72:2970–2979. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Rebecca VW and Amaravadi RK: Emerging
strategies to effectively target autophagy in cancer. Oncogene.
35:1–11. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Thorburn A, Thamm DH and Gustafson DL:
Autophagy and cancer therapy. Mol Pharmacol. 85:830–838. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Yang M, Zeng P, Kang R, Yu Y, Yang L, Tang
D and Cao L: S100A8 contributes to drug resistance by promoting
autophagy in leukemia cells. PLoS One. 9:e972422014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Ajabnoor GM, Crook T and Coley HM:
Paclitaxel resistance is associated with switch from apoptotic to
autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis.
3:e2602012. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Qadir MA, Kwok B, Dragowska WH, To KH, Le
D, Bally MB and Gorski SM: Macroautophagy inhibition sensitizes
tamoxifen-resistant breast cancer cells and enhances mitochondrial
depolarization. Breast Cancer Res Treat. 112:389–403. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Sun WL, Chen J, Wang YP and Zheng H:
Autophagy protects breast cancer cells from epirubicin-induced
apoptosis and facilitates epirubicin-resistance development.
Autophagy. 7:1035–1044. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Guo JY, Teng X, Laddha SV, Ma S, Van
Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD and White E:
Autophagy provides metabolic substrates to maintain energy charge
and nucleotide pools in Ras-driven lung cancer cells. Genes Dev.
30:1704–1717. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Guo JY and White E: Autophagy, metabolism,
and cancer. Cold Spring Harb Symp Quant Biol. 81:73–78. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Kimmelman AC and White E: Autophagy and
tumor metabolism. Cell Metab. 25:1037–1043. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Rangwala R, Chang YC, Hu J, Algazy KM,
Evans TL, Fecher LA, Schuchter LM, Torigian DA, Panosian JT and
Troxel AB: Combined MTOR and autophagy inhibition: Phase I trial of
hydroxychloroquine and temsirolimus in patients with advanced solid
tumors and melanoma. Autophagy. 10:1391–1402. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Levy JMM, Towers CG and Thorburn A:
Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Yao D, Wang P, Zhang J, Fu L, Ouyang L and
Wang J: Deconvoluting the relationships between autophagy and
metastasis for potential cancer therapy. Apoptosis. 21:683–698.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Debnath J: Detachment-induced autophagy
during anoikis and lumen formation in epithelial acini. Autophagy.
4:351–353. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Herrero-Martin G, Hoyer-Hansen M,
Garcia-Garcia C, Fumarola C, Farkas T, López-Rivas A and Jäättelä
M: TAK1 activates AMPK-dependent cytoprotective autophagy in
TRAIL-treated epithelial cells. EMBO J. 28:677–685. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Sosa MS, Bragado P and Aguirre-Ghiso JA:
Mechanisms of disseminated cancer cell dormancy: An awakening
field. Nat Rev Cancer. 14:611–622. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Ojha R, Bhattacharyya S and Singh SK:
Autophagy in cancer stem cells: A potential link between
chemoresistance, recurrence, and metastasis. Biores Open Access.
4:97–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare
S, Kondo S, Kondo Y, Yu Y, Mills GB, et al: The tumor suppressor
gene ARHI regulates autophagy and tumor dormancy in human
ovarian cancer cells. J Clin Invest. 118:3917–3929. 2008.PubMed/NCBI
|
|
53
|
Maes H, Kuchnio A, Peric A, Moens S, Nys
K, De Bock K, Quaegebeur A, Schoors S, Georgiadou M, Wouters J, et
al: Tumor vessel normalization by chloroquine independent of
autophagy. Cancer Cell. 26:190–206. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Zhao X, Fang Y, Yang Y, Qin Y, Wu P, Wang
T, Lai H, Meng L, Wang D, Zheng Z, et al: Elaiophylin, a novel
autophagy inhibitor, exerts antitumor activity as a single agent in
ovarian cancer cells. Autophagy. 11:1849–1863. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Zhou J, Dong D, Cheng R, Wang Y, Jiang S,
Zhu Y, Fan L, Mao X, Gui Y, Li Z, et al: Aberrant expression of
KPNA2 is associated with a poor prognosis and contributes to OCT4
nuclear transportation in bladder cancer. Oncotarget.
7:72767–72776. 2016.PubMed/NCBI
|
|
56
|
Takada T, Tsutsumi S, Takahashi R, Ohsone
K, Tatsuki H, Suto T, Kato T, Fujii T, Yokobori T and Kuwano H:
KPNA2 over-expression is a potential marker of prognosis and
therapeutic sensitivity in colorectal cancer patients. J Surg
Oncol. 113:213–217. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
White E: Autophagy and p53. Cold Spring
Harb Perspect Med. 6:a0261202016. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Liu J, Zhang C, Hu W and Feng Z: Tumor
suppressor p53 and its mutants in cancer metabolism. Cancer Lett.
356:197–203. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Lu Y, Xiao L, Liu Y, Wang H, Li H, Zhou Q,
Pan J, Lei B, Huang A and Qi S: MIR517C inhibits autophagy
and the epithelial-to-mesenchymal (-like) transition phenotype in
human glioblastoma through KPNA2-dependent disruption of TP53
nuclear translocation. Autophagy. 11:2213–2232. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Maiuri MC, Galluzzi L, Morselli E, Kepp O,
Malik SA and Kroemer G: Autophagy regulation by p53. Curr Opin Cell
Biol. 22:181–185. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Galluzzi L, Morselli E, Kepp O, Maiuri MC
and Kroemer G: Defective autophagy control by the p53 rheostat in
cancer. Cell Cycle. 9:250–255. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
O'Brate A and Giannakakou P: The
importance of p53 location: Nuclear or cytoplasmic zip code? Drug
Resist Updat. 6:313–322. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Kim IS, Kim DH, Han SM, Chin MU, Nam HJ,
Cho HP, Choi SY, Song BJ, Kim ER, Bae YS and Moon YH: Truncated
form of importin alpha identified in breast cancer cell inhibits
nuclear import of p53. J Biol Chem. 275:23139–23145. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Kau TR and Silver PA: Nuclear transport as
a target for cell growth. Drug Discov Today. 8:78–85. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Jamali T, Jamali Y, Mehrbod M and Mofrad
MR: Nuclear pore complex: Biochemistry and biophysics of
nucleocytoplasmic transport in health and disease. Int Rev Cell Mol
Biol. 287:233–286. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Dickmanns A, Kehlenbach RH and Fahrenkrog
B: Nuclear pore complexes and nucleocytoplasmic transport: From
structure to function to disease. Int Rev Cell Mol Biol.
320:171–233. 2015. View Article : Google Scholar : PubMed/NCBI
|
