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Article

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma

  • Authors:
    • Jing Huang
    • Weiyuan Huang
    • Mei Liu
    • Jianping Zhu
    • Danxian Jiang
    • Yinghuan Xiong
    • Yan Zhen
    • Donghong Yang
    • Zihong Chen
    • Lijiao Peng
    • Zhonghua Yu
  • View Affiliations / Copyright

    Affiliations: Oncology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, Oncology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Pathological Diagnosis and Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Institute of Respiratory Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
  • Pages: 1017-1025
    |
    Published online on: June 14, 2018
       https://doi.org/10.3892/or.2018.6490
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Abstract

SETDB1, an H3K9‑specific histone methyltransferase, has been described as a repressed transcription marker which triggers tumorigenesis of many types of human cancer. However, there are few studies elucidating the relationship between SETDB1 and nasopharyngeal carcinoma. In the present study, we confirmed that SETDB1 exhibited higher expression levels in nasopharyngeal carcinoma (NPC) tissues and cell lines, compared to these levels in non‑tumor tissues and a normal human nasopharyngeal epithelial cell line. Kaplan‑Meier analysis showed that higher SETDB1 expression indicated an unfavorable prognosis for NPC patients, making it an independent prognostic factor for NPC in the COX proportional hazards model. In vitro functional studies revealed that upregulation of SETDB1 expression in CNE1 cells promoted cell proliferation, possibly through cell cycle G1/S phase transition. Moreover, it also enhanced cell migration and invasion ability. Downregulation of SETDB1 expression in 5‑8F cells resulted in the opposite response. Overall, the findings indicated that increased expression of SETDB1 may predict poor overall survival and the malignant phenotype of NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Huang W, Liu M, Zhu J, Jiang D, Xiong Y, Zhen Y, Yang D, Chen Z, Peng L, Peng L, et al: Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma. Oncol Rep 40: 1017-1025, 2018.
APA
Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y. ... Yu, Z. (2018). Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma. Oncology Reports, 40, 1017-1025. https://doi.org/10.3892/or.2018.6490
MLA
Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y., Zhen, Y., Yang, D., Chen, Z., Peng, L., Yu, Z."Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma". Oncology Reports 40.2 (2018): 1017-1025.
Chicago
Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y., Zhen, Y., Yang, D., Chen, Z., Peng, L., Yu, Z."Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma". Oncology Reports 40, no. 2 (2018): 1017-1025. https://doi.org/10.3892/or.2018.6490
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Huang W, Liu M, Zhu J, Jiang D, Xiong Y, Zhen Y, Yang D, Chen Z, Peng L, Peng L, et al: Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma. Oncol Rep 40: 1017-1025, 2018.
APA
Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y. ... Yu, Z. (2018). Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma. Oncology Reports, 40, 1017-1025. https://doi.org/10.3892/or.2018.6490
MLA
Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y., Zhen, Y., Yang, D., Chen, Z., Peng, L., Yu, Z."Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma". Oncology Reports 40.2 (2018): 1017-1025.
Chicago
Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y., Zhen, Y., Yang, D., Chen, Z., Peng, L., Yu, Z."Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma". Oncology Reports 40, no. 2 (2018): 1017-1025. https://doi.org/10.3892/or.2018.6490
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