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Article

ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo

  • Authors:
    • Zhiyuan Lou
    • Bok‑Soon Lee
    • Taekyu Ha
    • Yanrui Xu
    • Haeng‑Jun Kim
    • Chul‑Ho Kim
    • Seong‑Ho Lee
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA, Department of Otolaryngology, School of Medicine, Ajou University, Yeongtong‑Gu, Suwon 16499, Republic of Korea
  • Pages: 1734-1742
    |
    Published online on: July 12, 2018
       https://doi.org/10.3892/or.2018.6560
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Abstract

Lung cancer is the first leading cause of cancer‑related death in the United States. Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and is associated with a poor patient prognosis. Identification of promising molecular targets is required for the effective prevention and therapy of NSCLC. Epithelial‑specific ETS‑1 (ESE‑1) belongs to the superfamily of ETS transcription factors. The effect of ESE‑1 on tumorigenesis is controversial in several types of cancer while its role in lung cancer remains unknown. The present study was designed to investigate whether ESE‑1 expression affects tumorigenic activity using human NSCLC cells and a mouse xenograft model. ESE‑1 expression suppressed anchorage‑independent growth in soft agar assay and led to an increase in G1 arrest and apoptosis in human NSCLC cells. ESE‑1 expression suppressed the invasion and migration of human NSCLC cells. Western blot analysis, RT‑PCR and promoter assay indicated that ESE‑1 expression was transcriptionally downregulated by treatment of transforming growth factor (TGF)‑β, an EMT (epithelial‑mesenchymal transition) stimulator. The xenograft study indicated that ESE‑1 expression inhibited tumor formation and development. Our data demonstrated that ESE‑1 plays a key role as a tumor suppressor in human NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Lou Z, Lee BS, Ha T, Xu Y, Kim HJ, Kim CH and Lee SH: ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo. Oncol Rep 40: 1734-1742, 2018.
APA
Lou, Z., Lee, B., Ha, T., Xu, Y., Kim, H., Kim, C., & Lee, S. (2018). ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo. Oncology Reports, 40, 1734-1742. https://doi.org/10.3892/or.2018.6560
MLA
Lou, Z., Lee, B., Ha, T., Xu, Y., Kim, H., Kim, C., Lee, S."ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo". Oncology Reports 40.3 (2018): 1734-1742.
Chicago
Lou, Z., Lee, B., Ha, T., Xu, Y., Kim, H., Kim, C., Lee, S."ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo". Oncology Reports 40, no. 3 (2018): 1734-1742. https://doi.org/10.3892/or.2018.6560
Copy and paste a formatted citation
x
Spandidos Publications style
Lou Z, Lee BS, Ha T, Xu Y, Kim HJ, Kim CH and Lee SH: ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo. Oncol Rep 40: 1734-1742, 2018.
APA
Lou, Z., Lee, B., Ha, T., Xu, Y., Kim, H., Kim, C., & Lee, S. (2018). ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo. Oncology Reports, 40, 1734-1742. https://doi.org/10.3892/or.2018.6560
MLA
Lou, Z., Lee, B., Ha, T., Xu, Y., Kim, H., Kim, C., Lee, S."ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo". Oncology Reports 40.3 (2018): 1734-1742.
Chicago
Lou, Z., Lee, B., Ha, T., Xu, Y., Kim, H., Kim, C., Lee, S."ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo". Oncology Reports 40, no. 3 (2018): 1734-1742. https://doi.org/10.3892/or.2018.6560
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