|
1
|
Ferlay J, Soerjomataram I, Dikshit R, Eser
S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer
incidence and mortality worldwide: Sources, methods and major
patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng
H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in
china.2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Nagini S: Carcinoma of the stomach: A
review of epidemiology, pathogenesis, molecular genetics and
chemoprevention. World J Gastrointest Oncol. 4:156–169. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Pasquale EB: Eph-ephrin promiscuity is now
crystal clear. Nat Neurosci. 7:417–418. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Pasquale EB: Eph receptor signalling casts
a wide net on cell behavior. Nat Rev Mol Cell Biol. 6:462–475.
2005. View
Article : Google Scholar : PubMed/NCBI
|
|
6
|
Pasquale EB: Eph receptors and ephrins in
cancer: Bidirectional signalling and beyond. Nat Rev Cancer.
10:165–180. 2010. View
Article : Google Scholar : PubMed/NCBI
|
|
7
|
Valsesia A, Rimoldi D, Martinet D,
Ibberson M, Benaglio P, Quadroni M, Waridel P, Gaillard M, Pidoux
M, Rapin B, et al: Network-guided analysis of genes with altered
somatic copy number and gene expression reveals pathways commonly
perturbed in metastatic melanoma. PLoS One. 6:e183692011.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wood LD, Calhoun ES, Silliman N, Ptak J,
Szabo S, Powell SM, Riggins GJ, Wang TL, Yan H, Gazdar A, et al:
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum
Mutat. 27:1060–1061. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Janes PW, Slape CI, Farnsworth RH,
Atapattu L, Scott AM and Vail ME: EphA3 biology and cancer. Growth
Factors. 32:176–189. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Day BW, Stringer BW, Al-Ejeh F, Ting MJ,
Wilson J, Ensbey KS, Jamieson PR, Bruce ZC, Lim YC, Offenhäuser C,
et al: EphA3 maintains tumorigenicity and is a therapeutic target
in glioblastoma multiforme. Cancer Cell. 23:238–248. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Brantley DM, Cheng N, Thompson EJ, Lin Q,
Brekken RA, Thorpe PE, Muraoka RS, Cerretti DP, Pozzi A, Jackson D,
et al: Soluble Eph A receptors inhibit tumor angiogenesis and
progression in vivo. Oncogene. 21:7011–7026. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Xi HQ, Wu XS, Wei B and Chen L: Aberrant
expression of EphA3 in gastric carcinoma: Correlation with tumor
angiogenesis and survival. J Gastroenterol. 47:785–794. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wang J, Dong Y, Wang X, Ma H, Sheng Z, Li
G, Lu G, Sugimura H and Zhou X: Expression of EphA1 in gastric
carcinomas is associated with metastasis and survival. Oncol Rep.
24:1577–1584. 2010.PubMed/NCBI
|
|
14
|
Nakamura R, Kataoka H, Sato N, Kanamori M,
Ihara M, Igarashi H, Ravshanov S, Wang YJ, Li ZY, Shimamura T, et
al: EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci.
96:42–47. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Wang J, Li G, Ma H, Bao Y, Wang X, Zhou H,
Sheng Z, Sugimura H, Jin J and Zhou X: Differential expression of
EphA7 receptor tyrosine kinase in gastric carcinoma. Hum Pathol.
38:1649–1656. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Carmeliet P and Jain RK: Angiogenesis in
cancer and other diseases. Nature. 407:249–257. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Brantley-Sieders DM, Fang WB, Hicks DJ,
Zhuang G, Shyr Y and Chen J: Impaired tumor microenvironment in
EphA2-deficient mice inhibits tumor angiogenesis and metastatic
progression. FASEB J. 19:1884–1886. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Dobrzanski P, Hunter K, Jones-Bolin S,
Chang H, Robinson C, Pritchard S, Zhao H and Ruggeri B:
Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist.
Cancer Res. 64:910–919. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Kertesz N, Krasnoperov V, Reddy R,
Leshanski L, Kumar SR, Zozulya S and Gill PS: The soluble
extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2
interaction, modulates angiogenesis, and inhibits tumor growth.
Blood. 107:2330–2338. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Martiny-Baron G, Korff T, Schaffner F,
Esser N, Eggstein S, Marmé D and Augustin HG: Inhibition of tumor
growth and angiogenesis by soluble EphB4. Neoplasia. 6:248–257.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Sawamiphak S, Seidel S, Essmann CL,
Wilkinson GA, Pitulescu ME, Acker T and Acker-Palmer A: Ephrin-B2
regulates VEGFR2 function in developmental and tumour angiogenesis.
Nature. 465:487–491. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wang Y, Nakayama M, Pitulescu ME, Schmidt
TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U,
et al: Ephrin-B2 controls VEGF-induced angiogenesis and
lymphangiogenesis. Nature. 465:483–486. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Caivano A, La Rocca F, Laurenzana I,
Annese T, Tamma R, Famigliari U, Simeon V, Trino S, De Luca L,
Villani O, et al: Epha3 acts as proangiogenic factor in multiple
myeloma. Oncotarget. 8:34298–34309. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
La Rocca F, Airoldi I, Di Carlo E, Marotta
P, Falco G, Simeon V, Laurenzana I, Trino S, De Luca L, Todoerti K,
et al: EphA3 targeting reduces in vitro adhesion and invasion and
in vivo growth and angiogenesis of multiple myeloma cells. Cell
Oncol (Dordr). 40:483–496. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Iruela-Arispe ML and Dvorak HF:
Angiogenesis: A dynamic balance of stimulators and inhibitors.
Thromb Haemost. 78:672–677. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Nicosia RF: What is the role of vascular
endothelial growth factor-related molecules in tumor angiogenesis?
Am J Pathol. 153:11–16. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Lu CY, Yang ZX, Zhou L, Huang ZZ, Zhang
HT, Li J, Tao KS and Xie BZ: High levels of EphA3 expression are
associated with high invasive capacity and poor overall survival in
hepatocellular carcinoma. Oncol Rep. 30:2179–2186. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Milanini J, Viñals F, Pouysségur J and
Pagès G: p42/p44 MAP kinase module plays a key role in the
transcriptional regulation of the vascular endothelial growth
factor gene in fibroblasts. J Biol Chem. 273:18165–19172. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Niu G, Wright KL, Huang M, Song L, Haura
E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, et al:
Constitutive Stat3 activity up-regulates VEGF expression and tumor
angiogenesis. Oncogene. 21:2000–2008. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Huang S: Regulation of metastases by
signal transducer and activator of transcription 3 signaling
pathway: Clinical implications. Clin Cancer Res. 13:1362–1366.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao
AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL and Xie K: Stat3
activation regulates the expression of vascular endothelial growth
factor and human pancreatic cancer angiogenesis and metastasis.
Oncogene. 22:319–329. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Cheong JH, Hong SY, Zheng Y and Noh SH:
Eupatilin inhibits gastric cancer cell growth by blocking
STAT3-mediated VEGF expression. J Gastric Cancer. 11:16–22. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Xu Q, Briggs J, Park S, Niu G, Kortylewski
M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, et al:
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by
multiple oncogenic growth signaling pathways. Oncogene.
24:5552–5560. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Uan ZL, Guan YJ, Wang L, Wei W, Kane AB
and Chin YE: Central role of the threonine residue within the p+1
loop of receptor tyrosine kinase in STAT3 constitutive
phosphorylation in metastatic cancer cells. Mol Cell Biol.
24:9390–9400. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Bong YS, Lee HS, Carim-Todd L, Mood K,
Nishanian TG, Tessarollo L and Daar IO: ephrinB1 signals from the
cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad
Sci USA. 104:17305–17310. View Article : Google Scholar : PubMed/NCBI
|
