Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation

Corrigendum in: /10.3892/or.2018.6863

  • Authors:
    • Kai Yin
    • Mengyuan Shang
    • Shengchun Dang
    • Linjun Wang
    • Yiwen Xia
    • Lei Cui
    • Xin Fan
    • Jianguo Qu
    • Jixiang Chen
    • Zekuan Xu
  • View Affiliations

  • Published online on: August 1, 2018     https://doi.org/10.3892/or.2018.6614
  • Pages: 2325-2333
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Abstract

Netrin‑1 (NTN1) has been demonstrated to promote tumorigenesis in multiple types of cancer; however, its role in the growth of gastric cancer (GC) cells has not been described in detail. In the present study, the data suggested that NTN1 knockdown significantly decreased the proliferation of GC cells, whereas NTN1 overexpression had an opposing effect. Furthermore, the use of focal adhesion kinase (FAK) inhibitor decreased the proliferation of GC cells. It was also revealed that NTN1 markedly induced the phosphorylation of FAK, extracellular signal‑regulated kinase (ERK) and c‑Jun N‑terminal kinase (JNK), but did not induce the phosphorylation of P38. In addition, the expression of ERK and JNK was markedly inhibited by treatment with FAK inhibitor. Xenograft analysis using GC cells revealed that NTN1 overexpression promoted tumor growth. Furthermore, the expression of NTN1 in samples collected from nude mice was downregulated in the NTN1 knockdown group and upregulated in the NTN1 overexpression group compared with the control short hairpin RNA group. These results suggest that NTN1‑induced GC cell proliferation is mediated by activating ERK/MAPK signaling cascades via the distinct activation of FAK.
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October-2018
Volume 40 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yin K, Shang M, Dang S, Wang L, Xia Y, Cui L, Fan X, Qu J, Chen J, Xu Z, Xu Z, et al: Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation Corrigendum in /10.3892/or.2018.6863. Oncol Rep 40: 2325-2333, 2018
APA
Yin, K., Shang, M., Dang, S., Wang, L., Xia, Y., Cui, L. ... Xu, Z. (2018). Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation Corrigendum in /10.3892/or.2018.6863. Oncology Reports, 40, 2325-2333. https://doi.org/10.3892/or.2018.6614
MLA
Yin, K., Shang, M., Dang, S., Wang, L., Xia, Y., Cui, L., Fan, X., Qu, J., Chen, J., Xu, Z."Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation Corrigendum in /10.3892/or.2018.6863". Oncology Reports 40.4 (2018): 2325-2333.
Chicago
Yin, K., Shang, M., Dang, S., Wang, L., Xia, Y., Cui, L., Fan, X., Qu, J., Chen, J., Xu, Z."Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation Corrigendum in /10.3892/or.2018.6863". Oncology Reports 40, no. 4 (2018): 2325-2333. https://doi.org/10.3892/or.2018.6614