Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression

  • Authors:
    • Wei‑Sheng Xiao
    • De‑Feng Li
    • Ya‑Ping Tang
    • Yan‑Zhu Chen
    • Wen‑Bing Deng
    • Juan Chen
    • Wei‑Wei Zhou
    • Ai‑Jun Liao
  • View Affiliations

  • Published online on: September 4, 2018     https://doi.org/10.3892/or.2018.6681
  • Pages: 2844-2853
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Abstract

Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of miR‑711 in gastric cancer tissues is low, and restoration of miR‑711 inhibited the invasion and migration and the occurrence of epithelial‑mesenchymal transition (EMT) in gastric cancer cells. Yet, the mechanisms involved in these processes remain unknown. In the present study, we demonstrated that miR‑711‑mediated downregulation of CD44 expression inhibited EMT of gastric cancer cells in vitro and in vivo by downregulating vimentin protein expression and upregulating E‑cadherin protein expression through transfection, qRT‑PCR and western blotting. Therefore, miR‑711 may provide a promising target for EMT‑related therapy for gastric cancer.
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November-2018
Volume 40 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xiao WS, Li DF, Tang YP, Chen YZ, Deng WB, Chen J, Zhou WW and Liao AJ: Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression. Oncol Rep 40: 2844-2853, 2018
APA
Xiao, W., Li, D., Tang, Y., Chen, Y., Deng, W., Chen, J. ... Liao, A. (2018). Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression. Oncology Reports, 40, 2844-2853. https://doi.org/10.3892/or.2018.6681
MLA
Xiao, W., Li, D., Tang, Y., Chen, Y., Deng, W., Chen, J., Zhou, W., Liao, A."Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression". Oncology Reports 40.5 (2018): 2844-2853.
Chicago
Xiao, W., Li, D., Tang, Y., Chen, Y., Deng, W., Chen, J., Zhou, W., Liao, A."Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression". Oncology Reports 40, no. 5 (2018): 2844-2853. https://doi.org/10.3892/or.2018.6681