Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2018 Volume 40 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 40 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

UCA1 overexpression is associated with less aggressive subtypes of bladder cancer

  • Authors:
    • Laetitia Lebrun
    • Dina Milowich
    • Marie Le Mercier
    • Justine Allard
    • Yves‑Rémi Van Eycke
    • Thierry Roumeguere
    • Christine Decaestecker
    • Isabelle Salmon
    • Sandrine Rorive
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), B‑1070 Brussels, Belgium, DIAPath‑Center for Microscopy and Molecular Imaging, ULB, B-6041 Gosselies, Belgium, Department of Urology, Erasme University Hospital, ULB, B‑1070 Brussels, Belgium, Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), B‑1070 Brussels, Belgium
    Copyright: © Lebrun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2497-2506
    |
    Published online on: September 10, 2018
       https://doi.org/10.3892/or.2018.6697
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑coding RNAs (ncRNAs) have been shown to serve important roles in carcinogenesis via complex mechanisms, including transcriptional and post‑transcriptional regulation, and chromatin interactions. Urothelial carcinoma‑associated 1 (UCA1), a long ncRNA, was recently shown to have tumorigenic properties in urothelial bladder cancer (UBC), as demonstrated by enhanced proliferation, migration, invasion and therapy resistance of UBC cell lines in vitro. These in vitro findings suggested that UCA1 is associated with aggressive tumor behavior and could have prognostic implications in UBC. The aims of the present study were to therefore to investigate the statistical associations between UCA1 RNA expression and UBC pathological features, patient prognosis and p53 and Ki‑67 expression. Chromogenic in situ hybridization and immunohistochemistry were performed on UBC tissue microarrays to characterize UCA1 RNA, and p53 and Ki‑67 expression in 208 UBC cases, including 145 non‑muscle‑invasive and 63 muscle‑invasive cases. UCA1 was observed in the tumor cells of 166/208 (80%) UBC cases tested. No expression was noted in normal stromal and endothelium cells. Patients with UBC that overexpressed UCA1 (35%) had a significantly higher survival rate (P=0.006) compared with that in patients with UBC that did not overexpress UCA1. This prognostic factor was independent of tumor morphology, concomitant carcinoma in situ, tumor grade and tumor stage. In addition, the absence of UCA1 overexpression was significantly associated with a high Ki‑67 proliferative index (P=0.008) and a p53 'mutated' immunoprofile (strong nuclear expression or complete absence of staining; P=0.003). In conclusion, the present results identified UCA1 as potentially being a novel independent prognostic marker in UBC that was associated with a better patient prognosis and that could serve a pivotal role in bladder cancer carcinogenesis.
View Figures

Figure 1

Figure 2

View References

1 

Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, et al: EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: Update 2016. Eur Urol. 71:447–461. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Witjes Alfred J, Lebret T, Compérat EM, Cowan NC, De Santis M, Bruins HM, Hernández V, Espinós EL, Dunn J, Rouanne M, et al: Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol. 71:462–475. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Knowles MA and Hurst CD: Molecular biology of bladder cancer: New insights into pathogenesis and clinical diversity. Nat Rev Cancer. 15:25–41. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sjödahl G, Lauss M, Lövgren K, Chebil G, Gudjonsson S, Veerla S, Patschan O, Aine M, Fernö M, Ringnér M, et al: A molecular taxonomy for urothelial carcinoma. Clin Cancer Res. 18:3377–3386. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Q, Su M, Lu G and Wang J: The complexity of bladder cancer: Long noncoding RNAs are on the stage. Mol Cancer. 12:1012013. View Article : Google Scholar : PubMed/NCBI

7 

Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, et al: Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res. 12:4851–4858. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Milowich D, Le Mercier M, De Neve N, Sandras F, Roumeguere T, Decaestecker C, Salmon I and Rorive S: Diagnostic value of the UCA1 test for bladder cancer detection: A clinical study. Springerplus. 4:3492015. View Article : Google Scholar : PubMed/NCBI

9 

Srivastava AK, Singh PK, Rath SK, Dalela D, Goel MM and Bhatt ML: Appraisal of diagnostic ability of UCA1 as a biomarker of carcinoma of the urinary bladder. Tumour Biol. 35:11435–11442. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Xue M, Li X, Li Z and Chen W: Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1α-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion. Tumour Biol. 35:6901–6912. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Wang X, Gong Y, Jin B, Wu C, Yang J, Wang L, Zhang Z and Mao Z: Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells. Oncol Rep. 32:1281–1290. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Yang C, Li X, Wang Y, Zhao L and Chen W: Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. 496:8–16. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Liu FT, Zhu PQ, Luo HL, Zhang Y and Qiu C: Prognostic value of long non-coding RNA UCA1 in human solid tumors. Oncotarget. 7:57991–58000. 2016.PubMed/NCBI

14 

Wang X, Peng F, Cheng L, Yang G, Zhang D, Liu J, Chen X and Zhao S: Prognostic and clinicopathological role of long non-coding RNA UCA1 in various carcinomas. Oncotarget. 8:28373–28384. 2017.PubMed/NCBI

15 

Droop J, Szarvas T, Schulz WA, Niedworok C, Niegisch G, Scheckenbach K and Hoffmann MJ: Diagnostic and prognostic value of long noncoding RNAs as biomarkers in urothelial carcinoma. PLoS One. 12:e01762872017. View Article : Google Scholar : PubMed/NCBI

16 

Ding W, Gou Y, Sun C, Xia G, Wang H, Chen Z, Tan J, Xu K and Qiang D: Ki-67 is an independent indicator in non-muscle invasive bladder cancer (NMIBC); combination of EORTC risk scores and Ki-67 expression could improve the risk stratification of NMIBC. Urol Oncol. 32(42): e13–e19. 2014.

17 

Margulis V, Shariat SF, Ashfaq R, Sagalowsky AI and Lotan Y: Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease. Clin Cancer Res. 12:7369–7373. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Moch H, Humphrey PA, Ulbright TM and Reuter VE: WHO Classification of Tumours of the Urinary System and Male Genital Organs. 4th edition. IARC; Lyon 8: 2016

19 

Brierley JD, Gospodarowicz MK and Wittekind C: The TNM Classification of Malignant Tumours. 8th edition. Union for International Cancer Control (UICC); Wiley-Blackwell: 2017

20 

Decaestecker C, Lopez XM, D'Haene N, Roland I, Guendouz S, Duponchelle C, Berton A, Debeir O and Salmon I: Requirements for the valid quantification of immunostains on tissue microarray materials using image analysis. Proteomics. 9:4478–4494. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Rorive S, Lopez XM, Maris C, Trepant AL, Sauvage S, Sadeghi N, Roland I, Decaestecker C and Salmon I: TIMP-4 and CD63: New prognostic biomarkers in human astrocytomas. Mod Pathol. 23:1418–1428. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Talhouk A, McConechy MK, Leung S, Li-Chang HH, Kwon JS, Melnyk N, Yang W, Senz J, Boyd N, Karnezis AN, et al: A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 113:299–310. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kurman RJ, Carcangiu ML, Herrington CS and Young RH: WHO classification of tumors of female reproductive organs. 4th edition. IARC; Lyon 6: 2014

24 

Mota A, Triviño JC, Rojo-Sebastian A, Martínez-Ramírez A, Chiva L, González-Martín A, Garcia JF, Garcia-Sanz P and Moreno-Bueno G: Intra-tumor heterogeneity in TP53 null high grade serous ovarian carcinoma progression. BMC Cancer. 15:9402015. View Article : Google Scholar : PubMed/NCBI

25 

Martens-Uzunova ES, Böttcher R, Croce CM, Jenster G, Visakorpi T and Calin GA: Long noncoding RNA in prostate, bladder, and kidney cancer. Eur Urol. 65:1140–1151. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Xue M, Chen W and Li X: Urothelial cancer associated 1: A long noncoding RNA with a crucial role in cancer. J Cancer Res Clin Oncol. 142:1407–1419. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Guhley ML and Tang W: Laboratory assays for Epstein-Barr virus-related disease. J Mol Diagn. 10:279–292. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Aine M, Eriksson P, Liedberg F, Höglund M and Sjödahl G: On molecular classification of bladder cancer: Out of one, many. Eur Urol. 68:921–923. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Kim PH, Cha EK, Sfakianos JP, Iyer G, Zabor EC, Scott SN, Ostrovnaya I, Ramirez R, Sun A, Shah R, et al: Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder. Eur Urol. 67:198–201. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kumar PP, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL and Moon AM: Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife. 3:2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lebrun L, Milowich D, Le Mercier M, Allard J, Van Eycke YR, Roumeguere T, Decaestecker C, Salmon I and Rorive S: UCA1 overexpression is associated with less aggressive subtypes of bladder cancer. Oncol Rep 40: 2497-2506, 2018.
APA
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T. ... Rorive, S. (2018). UCA1 overexpression is associated with less aggressive subtypes of bladder cancer. Oncology Reports, 40, 2497-2506. https://doi.org/10.3892/or.2018.6697
MLA
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T., Decaestecker, C., Salmon, I., Rorive, S."UCA1 overexpression is associated with less aggressive subtypes of bladder cancer". Oncology Reports 40.5 (2018): 2497-2506.
Chicago
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T., Decaestecker, C., Salmon, I., Rorive, S."UCA1 overexpression is associated with less aggressive subtypes of bladder cancer". Oncology Reports 40, no. 5 (2018): 2497-2506. https://doi.org/10.3892/or.2018.6697
Copy and paste a formatted citation
x
Spandidos Publications style
Lebrun L, Milowich D, Le Mercier M, Allard J, Van Eycke YR, Roumeguere T, Decaestecker C, Salmon I and Rorive S: UCA1 overexpression is associated with less aggressive subtypes of bladder cancer. Oncol Rep 40: 2497-2506, 2018.
APA
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T. ... Rorive, S. (2018). UCA1 overexpression is associated with less aggressive subtypes of bladder cancer. Oncology Reports, 40, 2497-2506. https://doi.org/10.3892/or.2018.6697
MLA
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T., Decaestecker, C., Salmon, I., Rorive, S."UCA1 overexpression is associated with less aggressive subtypes of bladder cancer". Oncology Reports 40.5 (2018): 2497-2506.
Chicago
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T., Decaestecker, C., Salmon, I., Rorive, S."UCA1 overexpression is associated with less aggressive subtypes of bladder cancer". Oncology Reports 40, no. 5 (2018): 2497-2506. https://doi.org/10.3892/or.2018.6697
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team