Open Access

Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma

  • Authors:
    • Dong Wang
    • Ruizhi Wang
    • Anpei Huang
    • Zeng Fang
    • Kebing Wang
    • Meifang He
    • Jin‑Tang Xia
    • Wen Li
  • View Affiliations

  • Published online on: September 12, 2018     https://doi.org/10.3892/or.2018.6703
  • Pages: 2628-2636
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Macrophage migration inhibitory factor (MIF) is a pro‑inflammatory cytokine that serves important roles in cancer. MIF overexpression is frequently observed in numerous human cancer types, including pancreatic carcinoma. However, the prognostic value and function of MIF in pancreatic ductal adenocarcinoma (PDAC) have not been fully elucidated. In the present study, upregulation of MIF expression in PDAC tissue compared with adjacent normal tissue was observed. Furthermore, MIF overexpression was identified to be significantly associated with poor survival rates in patients with PDAC. Multivariate Cox regression analysis confirmed that MIF was an independent risk factor for poor survival. Functional analyses demonstrated that MIF knockdown significantly inhibited the proliferation and invasion of pancreatic cancer cells in vitro compared with control cells. IN addition, mechanistic investigations revealed that silencing MIF leads to inhibition of AKT serine/threonine kinase and extracellular‑signal‑regulated kinase activation, and suppression of cyclin D1 and matrix metalloproteinase‑2 expression, which may suppress tumor proliferation and invasion. These results highlight the importance of MIF overexpression in PDAC aggressiveness, and indicate that MIF may be a potential therapeutic target for pancreatic cancer.
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November-2018
Volume 40 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang D, Wang R, Huang A, Fang Z, Wang K, He M, Xia JT and Li W: Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma. Oncol Rep 40: 2628-2636, 2018
APA
Wang, D., Wang, R., Huang, A., Fang, Z., Wang, K., He, M. ... Li, W. (2018). Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma. Oncology Reports, 40, 2628-2636. https://doi.org/10.3892/or.2018.6703
MLA
Wang, D., Wang, R., Huang, A., Fang, Z., Wang, K., He, M., Xia, J., Li, W."Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma". Oncology Reports 40.5 (2018): 2628-2636.
Chicago
Wang, D., Wang, R., Huang, A., Fang, Z., Wang, K., He, M., Xia, J., Li, W."Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma". Oncology Reports 40, no. 5 (2018): 2628-2636. https://doi.org/10.3892/or.2018.6703