|
1
|
Hundal R and Shaffer EA: Gallbladder
cancer: Epidemiology and outcome. Clin Epidemiol. 6:99–109.
2014.PubMed/NCBI
|
|
2
|
Wang J, Narang AK, Sugar EA, Luber B,
Rosati LM, Hsu CC, Fuller CD, Pawlik TM, Miller RC, Czito BG, et
al: Evaluation of adjuvant radiation therapy for resected
gallbladder carcinoma: A multi-institutional experience. Ann Surg
Oncol. 22 Suppl 3:S1100–S1106. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Zhu AX, Hong TS, Hezel AF and Kooby DA:
Current management of gallbladder carcinoma. Oncologist.
15:168–181. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Riffle S, Pandey RN, Albert M and Hegde
RS: Linking hypoxia, DNA damage and proliferation in multicellular
tumor spheroids. BMC Cancer. 17:3382017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ji RC: Hypoxia and lymphangiogenesis in
tumor microenvironment and metastasis. Cancer Lett. 346:6–16. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lin YJ, Shyu WC, Chang CW, Wang CC, Wu CP,
Lee HT, Chen LJ and Hsieh CH: Tumor hypoxia regulates forkhead Box
C1 to promote lung cancer progression. Theranostics. 7:1177–1191.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Xu W, Zhou W, Cheng M, Wang J, Liu Z, He
S, Luo X, Huang W, Chen T, Yan W and Xiao J: Hypoxia activates
Wnt/β-catenin signaling by regulating the expression of BCL9 in
human hepatocellular carcinoma. Sci Rep. 7:404462017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Unwith S, Zhao H, Hennah L and Ma D: The
potential role of HIF on tumour progression and dissemination. Int
J Cancer. 136:2491–2503. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Chen MC, Hsu WL, Hwang PA and Chou TC: Low
molecular weight fucoidan inhibits tumor angiogenesis through
downregulation of HIF-1/VEGF signaling under hypoxia. Mar Drugs.
13:4436–4451. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kawamoto M, Onishi H, Ozono K, Yamasaki A,
Imaizumi A, Kamakura S, Nakano K, Oda Y, Suminoto H and Nakamura M:
Tropomyosin-related kinase B mediated signaling contributes to the
induction of malignant phenotype of gallbladder cancer. Oncotarget.
8:36211–36224. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Valsecchi R, Coltella N, Belloni D,
Ponente M, Ten Hacken E, Scielzo C, Scarfo L, Bertilaccio MT,
Brambilla P, Lenti E, et al: HIF-1α regulates the interaction of
chronic lymphocytic leukemia cells with the tumor microenvironment.
Blood. 127:1987–1997. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Gao T, Li JZ, Lu Y, Zhang CY, Li Q, Mao J
and Li LH: The mechanism between epithelial mesenchymal transition
in breast cancer and hypoxia microenvironment. Biomed Pharmacother.
80:393–405. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wang J, Gao Q, Wang D, Wang Z and Hu C:
Metformin inhibits growth of lung adenocarcinoma cells by inducing
apoptosis via the mitochondria-mediated pathway. Oncol Lett.
10:1343–1349. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Chung HH, Moon JS, Yoon JS, Lee HW and Won
KC: The relationship between metformin and cancer in patients with
type 2 diabetes. Diabetes Metab J. 37:125–131. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Hall C, Stone RL, Gehlot A, Zorn KK and
Burnett AF: Use of metformin in obese women with type i endometrial
cancer is associated with a reduced incidence of cancer recurrence.
Int J Gynecol Cancer. 26:313–317. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liu Y, Wang Z, Li M, Ye Y, Xu Y, Zhang Y,
Yuan R, Jin Y, Hao Y, Jiang L, et al: Chloride intracellular
channel 1 regulates the antineoplastic effects of metformin in
gallbladder cancer cells. Cancer Sci. 108:1240–1252. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
He C, Wang L, Zhang J and Xu H:
Hypoxia-inducible microRNA-224 promotes the cell growth, migration
and invasion by directly targeting RASSF8 in gastric cancer. Mol
Cancer. 16:352017. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Guimaraes TA, Farias LC, Santos ES, de
Carvalho Fraga CA, Orsini LA, de Freitas Teles L, Feltenberger JD,
de Jesus SF, de Souza MG, Santos SH, et al: Metformin increases PDH
and suppresses HIF-1α under hypoxic conditions and induces cell
death in oral squamous cell carcinoma. Oncotarget. 7:55057–55068.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhou X, Chen J, Yi G, Deng M, Liu H, Liang
M, Shi B, Fu X, Chen Y, Chen L, et al: Metformin suppresses
hypoxia-induced stabilization of HIF-1α through reprogramming of
oxygen metabolism in hepatocellular carcinoma. Oncotarget.
7:873–884. 2016.PubMed/NCBI
|
|
20
|
Ma F, Wang SH, Cai Q, Zhang MD, Yang Y and
Ding J: Overexpression of LncRNA AFAP1-AS1 predicts poor prognosis
and promotes cells proliferation and invasion in gallbladder
cancer. Biomed Pharmacother. 84:1249–1255. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Brodowska K, Theodoropoulou S, Hörste
Meyer Zu M, Paschalis EI, Takeuchi K, Scott G, Ramsey DJ, Kiernan
E, Hoang M, Cichy J, et al: Effects of metformin on retinoblastoma
growth in vitro and in vivo. Int J Oncol. 45:2311–2324. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Rico M, Baglioni M, Bondarenko M, Laluce
NC, Rozados V, André N, Carré M, Scharovsky OG and Márquez Menacho
M: Metformin and propranolol combination prevents cancer
progression and metastasis in different breast cancer models.
Oncotarget. 8:2874–2889. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang SH, Zhang WJ, Wu XC, Zhang MD, Weng
MZ, Zhou D, Wang JD and Quan ZW: Long non-coding RNA Malat1
promotes gallbladder cancer development by acting as a molecular
sponge to regulate miR-206. Oncotarget. 7:37857–37867.
2016.PubMed/NCBI
|
|
25
|
Sun W, Shen ZY, Zhang H, Fan YZ, Zhang WZ,
Zhang JT, Lu XS and Ye C: Overexpression of HIF-1α in primary
gallbladder carcinoma and its relation to vasculogenic mimicry and
unfavourable prognosis. Oncol Rep. 27:1990–2002. 2012.PubMed/NCBI
|
|
26
|
Batmunkh E, Shimada M, Morine Y, Imura S,
Kanemura H, Arakawa Y, Hanaoka J, Kanamoto M, Sugimoto K and Nishi
M: Expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) in
patients with the gallbladder carcinoma. Int J Clin Oncol.
15:59–64. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wilson WR and Hay MP: Targeting hypoxia in
cancer therapy. Nat Rev Cancer. 11:393–410. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Song Y, Zheng S, Wang J, Long H, Fang L,
Wang G, Li Z, Que T, Liu Y, Li Y, et al: Hypoxia-induced PLOD2
promotes proliferation, migration and invasion via PI3K/Akt
signaling in glioma. Oncotarget. 8:41947–41962. 2017.PubMed/NCBI
|
|
29
|
Salceda S and Caro J: Hypoxia-inducible
factor 1α (HIF-1α) protein is rapidly degraded by the
ubiquitin-proteasome system under normoxic conditions. Its
stabilization by hypoxia depends on redox-induced changes. J Biol
Chem. 272:22642–22647. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Cheng K and Hao M: Metformin inhibits
TGF-β1-induced epithelial-to-mesenchymal transition via PKM2
relative-mTOR/p70s6k signaling pathway in cervical carcinoma cells.
Int J Mol Sci. 17:E20002016. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Yu T, Wang C, Yang J, Guo Y, Wu Y and Li
X: Metformin inhibits SUV39H1-mediated migration of prostate cancer
cells. Oncogenesis. 6:e3242017. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Tian Y, Tang B, Wang C, Sun D, Zhang R,
Luo N, Han Z, Liang R, Gao Z and Wang L: Metformin mediates
resensitivity to 5-fluorouracil in hepatocellular carcinoma via the
suppression of YAP. Oncotarget. 7:46230–46241. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Ling S, Xie H, Yang F, Shan Q, Dai H, Zhou
J, Wei X, Song P, Zhou L, Xu X and Zheng S: Metformin potentiates
the effect of arsenic trioxide suppressing intrahepatic
cholangiocarcinoma: Roles of p38 MAPK, ERK3, and mTORC1. J Hematol
Oncol. 10:592017. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Harada K, Ferdous T, Harada T and Ueyama
Y: Metformin in combination with 5-fluorouracil suppresses tumor
growth by inhibiting the warburg effect in human oral squamous cell
carcinoma. Int J Oncol. 49:276–284. 2016. View Article : Google Scholar : PubMed/NCBI
|
