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Article Open Access

Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer

Retraction in: /10.3892/or.2025.8973
  • Authors:
    • Yi Lei
    • Wang Guo
    • Bowang Chen
    • Lu Chen
    • Jiaxin Gong
    • Weimin Li
  • View Affiliations / Copyright

    Affiliations: International Medical Center/Department of General Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3438-3446
    |
    Published online on: October 3, 2018
       https://doi.org/10.3892/or.2018.6762
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Abstract

Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become one major obstacle for improving the clinical outcome of patients with metastatic and advanced‑stage non‑small cell lung cancer (NSCLC). While cell behavior can be modulated by long non‑coding RNAs (lncRNAs), the contributions of lncRNAs within extracellular vesicles (exosomes) are largely unknown. To this end, the involvement and regulatory functions of lncRNA H19 wrapped by exosomes during formation of gefitinib resistance in human NSCLC were investigated. Gefitinib‑resistant cell lines were built by continuously grafting HCC827 and HCC4006 cells into gefitinib‑contained culture medium. RT‑qPCR assays indicated that H19 was increased in gefitinib‑resistant cells when compared to sensitive parent cells. Functional experiments revealed that silencing of H19 potently promoted gefitinib‑induced cell cytotoxicity. H19 was secreted by packaging into exosomes and this packaging process was specifically mediated by hnRNPA2B1. H19 wrapped in exosomes could be transferred to non‑resistant cells, thus inducing gefitinib resistance. Moreover, treatment‑sensitive cells with exosomes highly‑expressing H19 induced gefitinib resistance, while knockdown of H19 abrogated this effect. In conclusion, H19 promoted gefitinib resistance of NSCLC cells by packaging into exosomes. Therefore, exosomal H19 may be a promising therapeutic target for EGFR+ NSCLC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Lei Y, Guo W, Chen B, Chen L, Gong J and Li W: Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973. Oncol Rep 40: 3438-3446, 2018.
APA
Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., & Li, W. (2018). Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973. Oncology Reports, 40, 3438-3446. https://doi.org/10.3892/or.2018.6762
MLA
Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., Li, W."Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973". Oncology Reports 40.6 (2018): 3438-3446.
Chicago
Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., Li, W."Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973". Oncology Reports 40, no. 6 (2018): 3438-3446. https://doi.org/10.3892/or.2018.6762
Copy and paste a formatted citation
x
Spandidos Publications style
Lei Y, Guo W, Chen B, Chen L, Gong J and Li W: Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973. Oncol Rep 40: 3438-3446, 2018.
APA
Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., & Li, W. (2018). Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973. Oncology Reports, 40, 3438-3446. https://doi.org/10.3892/or.2018.6762
MLA
Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., Li, W."Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973". Oncology Reports 40.6 (2018): 3438-3446.
Chicago
Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., Li, W."Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Retraction in /10.3892/or.2025.8973". Oncology Reports 40, no. 6 (2018): 3438-3446. https://doi.org/10.3892/or.2018.6762
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