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Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer

  • Authors:
    • Yin Peng
    • Xiaojing Zhang
    • Huijuan Lin
    • Shiqi Deng
    • Yong Huang
    • Ying  Qin
    • Xianling Feng
    • Ruibin Yan
    • Yanqiu Zhao
    • Yulan Cheng
    • Yanjie Wei
    • Jian Wang
    • Wangchun Chen
    • Xinmin Fan
    • Hassan Ashktorab
    • Duane Smoot
    • Stephen J. Meltzer
    • Song Li
    • Zhong Zhang
    • Zhe Jin
  • View Affiliations / Copyright

    Affiliations: Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, P.R. China, Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, P.R. China, Department of Pathology and Pathophysiology, The Guangzhou Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Gastrointestinal Surgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518000, P.R. China, Laboratory of Chemical Genomics, The Shenzhen Graduate School of Peking University, Shenzhen, Guangdong 518055, P.R. China, Department of Medicine/GI Division, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA, Center for High Performance Computing, Shenzhen Institutes of Advanced Technology, Shenzhen, Guangdong 518000, P.R. China, Department of Pathology and Pathophysiology, The Guangzhou Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Medicine and Cancer Center, Howard University, College of Medicine, Washington, DC 20060, USA, Department of Medicine, Meharry Medical Center, Nashville, TN 37208, USA, Department of Pathology, College of Basic Medical Sciences, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3323-3334
    |
    Published online on: October 8, 2018
       https://doi.org/10.3892/or.2018.6773
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Abstract

A mounting body of evidence has revealed that microRNAs (miRs) serve pivotal roles in various developmental processes, and in tumourigenesis, by binding to target genes and subsequently regulating gene expression. Continued activation of the Wnt/β‑catenin signalling is positively associated with human malignancy. In addition, miR‑194 dysregulation has been implicated in gastric cancer (GC); however, the molecular mechanisms underlying the effects of miR‑194 on GC carcinogenesis remain to be elucidated. The present study demonstrated that miR‑194 was upregulated in GC tissues and SUFU negative regulator of Ηedgehog signaling (SUFU) was downregulated in GC cell lines. Subsequently, inhibition of miR‑194 attenuated nuclear accumulation of β‑catenin, which consequently blocked Wnt/β‑catenin signalling. In addition, the cytoplasmic translocation of β‑catenin induced by miR‑194 inhibition was mediated by SUFU. Furthermore, genes associated with the Wnt/β‑catenin signalling pathway were revealed to be downregulated following inhibition of the Wnt signalling pathway by miR‑194 suppression. Finally, the results indicated that cell apoptosis was markedly increased in response to miR‑194 inhibition, strongly suggesting the carcinogenic effects of miR‑194 in GC. Taken together, these findings demonstrated that miR‑194 may promote gastric carcinogenesis through activation of the Wnt/β‑catenin signalling pathway, making it a potential therapeutic target for GC.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Forman D and Burley VJ: Gastric cancer: Global pattern of the disease and an overview of environmental risk factors. Best Pract Res Clin Gastroenterol. 20:633–649. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Lee RC, Feinbaum RL and Ambrost V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Garzon R, Calin GA and Croce CM: MicroRNAs in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Carleton M, Cleary MA and Linsley PS: MicroRNAs and cell cycle regulation. Cell Cycle. 6:2127–2132. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Cheng AM, Byrom MW, Shelton J and Ford LP: Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 33:1290–1297. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Garzon R, Marcucci G and Croce CM: Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat Rev Drug Discov. 9:775–789. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Peng Y, Zhang X, Ma Q, Yan R, Qin Y, Zhao Y, Cheng Y, Yang M, Wang Q, Feng X, et al: MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU. Cancer Lett. 385:117–127. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Klaus A and Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 8:387–398. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Zhou W, Li Y, Gou S, Xiong J, Wu H, Wang C, Yan H and Liu T: MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway. Oncotarget. 6:37557–37569. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Li T, Lai Q, Wang S, Cai J, Xiao Z, Deng D, He L, Jiao H, Ye Y, Liang L, et al: MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer. J Exp Clin Cancer Res. 35:212016. View Article : Google Scholar : PubMed/NCBI

12 

Taipaleenmäki H, Farina NH, van Wijnen AJ, Stein JL, Hesse E, Stein GS and Lian JB: Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells. Oncotarget. 7:79032–79046. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Capes-Davis A, Theodosopoulos G, Atkin I, Drexler HG, Kohara A, MacLeod RA, Masters JR, Nakamura Y, Reid YA, Reddel RR, et al: Check your cultures! A list of cross-contaminated or misidentified cell lines. Int J Cancer. 127:1–8. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Jin HY, Gonzalez-Martin A, Miletic AV, Lai M, Knight S, Sabouri-Ghomi M, Head SR, Macauley MS, Rickert RC and Xiao C: Transfection of microRNA mimics should be used with caution. Front Genet. 6:3402015. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Song X, Xin N, Wang W and Zhao C: Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. Oncotarget. 6:35579–35588. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, et al: β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology. 141:553–564. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P and Peek RM Jr: Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res. 68:379–387. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, et al: Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell. 149:1245–1256. 2012. View Article : Google Scholar : PubMed/NCBI

20 

He X, Semenov M, Tamai K and Zeng X: LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way. Development. 131:1663–1677. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Balciunaite G, Keller MP, Balciunaite E, Piali L, Zuklys S, Mathieu YD, Gill J, Boyd R, Sussman DJ and Holländer GA: Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol. 3:1102–1108. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M and Bejsovec A: Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 395:604–608. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Eastman Q and Grosschedl R: Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol. 11:233–240. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Wang SH, Li N, Wei Y, Li QR and Yu ZP: β-catenin deacetylation is essential for WNT-induced proliferation of breast cancer cells. Mol Med Rep. 9:973–978. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, Li Y and Wang Y: Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. Tumour Biol. 37:15211–15220. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Nikuševa-Martić T, Serman L, Zeljko M, Vidas Z, Gašparov S, Zeljko HM, Kosović M and Pećina-Šlaus N: Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma. Pathol Oncol Res. 19:545–551. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang K, Zhu S, Liu Y, Dong X, Shi Z, Zhang A, Liu C, Chen L, Wei J, Pu P, et al: ICAT inhibits glioblastoma cell proliferation by suppressing Wnt/β-catenin activity. Cancer Lett. 357:404–411. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, et al: Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 14:1741–1749. 2000.PubMed/NCBI

29 

Wang S, Krinks M, Lin K, Luyten FP and Moos M Jr: Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell. 88:757–766. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Kiper POS, Saito H, Gori F, Unger S, Hesse E, Yamana K, Kiviranta R, Solban N, Liu J, Brommage R, et al: Cortical-bone fragility - insights from sFRP4 deficiency in Pyle's disease. N Engl J Med. 374:2553–2562. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M and Ishitani T: NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 31:1904–1915. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Townsley FM, Cliffe A and Bienz M: Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function. Nat Cell Biol. 6:626–633. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S, Murone M, Züllig S and Basler K: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell. 109:47–60. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Paluszczak J, Wiśniewska D, Kostrzewska-Poczekaj M, Kiwerska K, Grénman R, Mielcarek-Kuchta D and Jarmuż-Szymczak M: Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas. Clin Oral Investig. 21:1777–1788. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Amen M, Liu X, Vadlamudi U, Elizondo G, Diamond E, Engelhardt JF and Amendt BA: PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Mol Cell Biol. 27:7560–7573. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Vadlamudi U, Espinoza HM, Ganga M, Martin DM, Liu X, Engelhardt JF and Amendt BA: PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter. J Cell Sci. 118:1129–1137. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Liu S, Zhu H, Zhang W, Zhang G, Zhou X, Zhou C, Quan L, Bai J, Xue L, et al: FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma. Int J Cancer. 123:561–568. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML and Weis WI: Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 33:719–731. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Bafico A, Liu G, Yaniv A, Gazit A and Aaronson SA: Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol. 3:683–686. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Li FQ, Mofunanya A, Harris K and Takemaru K: Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity. J Cell Biol. 181:1141–1154. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, et al: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature. 417:664–667. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J and Yeh ET: SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 38:191–201. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Ingham PW and Placzek M: Orchestrating ontogenesis: Variations on a theme by sonic Ηedgehog. Nat Rev Genet. 7:841–850. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Ingham PW, Nakano Y and Seger C: Mechanisms and functions of Ηedgehog signalling across the metazoa. Nat Rev Genet. 12:393–406. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Merchant M, Vajdos FF, Ultsch M, Maun HR, Wendt U, Cannon J, Desmarais W, Lazarus RA, de Vos AM and de Sauvage FJ: Suppressor of fused regulates Gli activity through a dual binding mechanism. Mol Cell Biol. 24:8627–8641. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Hana Y, Shia Q and Jiang J: Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction. Proc Natl Acad Sci USA. 112:6383–6388. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergström A, Ericson J, Toftgård R and Teglund S: Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Ηedgehog signaling pathway. Dev Cell. 10:187–197. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Taylor MD, Zhang X, Liu L, Hui CC, Mainprize TG, Scherer SW, Wainwright B, Hogg D and Rutka JT: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene. 23:4577–4583. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Smith MJ, Beetz C, Williams SG, Bhaskar SS, O'Sullivan J, Anderson B, Daly SB, Urquhart JE, Bholah Z, Oudit D, et al: Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations. J Clin Oncol. 32:4155–4161. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Brugières L, Remenieras A, Pierron G, Varlet P, Forget S, Byrde V, Bombled J, Puget S, Caron O, Dufour C, et al: High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. J Clin Oncol. 30:2087–2093. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Liu X, Wang X, Du W, Chen L, Wang G, Cui Y, Liu Y, Dou Z, Wang H, Zhang P, et al: Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis. Oncotarget. 5:11681–11694. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Lee Y, Kawagoe R, Sasai K, Li Y, Russell HR, Curran T and McKinnon PJ: Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene. 26:6442–6447. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Yan R, Peng X, Yuan X, Huang D, Chen J, Lu Q, Lv N and Luo S: Suppression of growth and migration by blocking the Ηedgehog signaling pathway in gastric cancer cells. Cell Oncol. 36:421–435. 2013. View Article : Google Scholar

54 

Chung TK, Lau TS, Cheung TH, Yim SF, Lo KW, Siu NS, Chan LK, Yu MY, Kwong J, Doran G, et al: Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1. Int J Cancer. 130:1036–1045. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Wijnhoven BP, Hussey DJ, Watson DI, Tsykin A, Smith CM and Michael MZ: South Australian Oesophageal Research Group: MicroRNA profiling of Barrett's oesophagus and oesophageal adenocarcinoma. Br J Surg. 97:853–861. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Song Y, Zhao F, Wang Z, Liu Z, Chiang Y, Xu Y, Gao P and Xu H: Inverse association between miR-194 expression and tumor invasion in gastric cancer. Ann Surg Oncol. 19 Suppl 3:S509–S517. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Li Z, Ying X, Chen H, Ye P, Shen Y, Pan W and Zhang L: MicroRNA-194 inhibits the epithelial-mesenchymal transition in gastric cancer cells by targeting FoxM1. Dig Dis Sci. 59:2145–2152. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Chen X, Wang Y, Zang W, Du Y, Li M and Zhao G: miR-194 targets RBX1 gene to modulate proliferation and migration of gastric cancer cells. Tumour Biol. 36:2393–2401. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Bao J, Zou JH, Li CY and Zheng GQ: miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B. Eur Rev Med Pharmacol Sci. 20:4487–4493. 2016.PubMed/NCBI

60 

Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J, et al: MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res. 20:784–793. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, et al: MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res. 70:2339–2349. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Shiotani A, Uedo N, Iishi H, Murao T, Kanzaki T, Kimura Y, Kamada T, Kusunoki H, Inoue K and Haruma K: H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands. J Gastroenterol. 47:988–998. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Daniels DL and Weis WI: ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell. 10:573–584. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Peng Y, Zhang X, Lin H, Deng S, Huang Y, Qin Y, Feng X, Yan R, Zhao Y, Cheng Y, Cheng Y, et al: Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer. Oncol Rep 40: 3323-3334, 2018.
APA
Peng, Y., Zhang, X., Lin, H., Deng, S., Huang, Y., Qin, Y. ... Jin, Z. (2018). Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer. Oncology Reports, 40, 3323-3334. https://doi.org/10.3892/or.2018.6773
MLA
Peng, Y., Zhang, X., Lin, H., Deng, S., Huang, Y., Qin, Y., Feng, X., Yan, R., Zhao, Y., Cheng, Y., Wei, Y., Wang, J., Chen, W., Fan, X., Ashktorab, H., Smoot, D., Meltzer, S. J., Li, S., Zhang, Z., Jin, Z."Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer". Oncology Reports 40.6 (2018): 3323-3334.
Chicago
Peng, Y., Zhang, X., Lin, H., Deng, S., Huang, Y., Qin, Y., Feng, X., Yan, R., Zhao, Y., Cheng, Y., Wei, Y., Wang, J., Chen, W., Fan, X., Ashktorab, H., Smoot, D., Meltzer, S. J., Li, S., Zhang, Z., Jin, Z."Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer". Oncology Reports 40, no. 6 (2018): 3323-3334. https://doi.org/10.3892/or.2018.6773
Copy and paste a formatted citation
x
Spandidos Publications style
Peng Y, Zhang X, Lin H, Deng S, Huang Y, Qin Y, Feng X, Yan R, Zhao Y, Cheng Y, Cheng Y, et al: Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer. Oncol Rep 40: 3323-3334, 2018.
APA
Peng, Y., Zhang, X., Lin, H., Deng, S., Huang, Y., Qin, Y. ... Jin, Z. (2018). Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer. Oncology Reports, 40, 3323-3334. https://doi.org/10.3892/or.2018.6773
MLA
Peng, Y., Zhang, X., Lin, H., Deng, S., Huang, Y., Qin, Y., Feng, X., Yan, R., Zhao, Y., Cheng, Y., Wei, Y., Wang, J., Chen, W., Fan, X., Ashktorab, H., Smoot, D., Meltzer, S. J., Li, S., Zhang, Z., Jin, Z."Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer". Oncology Reports 40.6 (2018): 3323-3334.
Chicago
Peng, Y., Zhang, X., Lin, H., Deng, S., Huang, Y., Qin, Y., Feng, X., Yan, R., Zhao, Y., Cheng, Y., Wei, Y., Wang, J., Chen, W., Fan, X., Ashktorab, H., Smoot, D., Meltzer, S. J., Li, S., Zhang, Z., Jin, Z."Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer". Oncology Reports 40, no. 6 (2018): 3323-3334. https://doi.org/10.3892/or.2018.6773
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