Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January-2019 Volume 41 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 41 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma

  • Authors:
    • Lin Zhuang
    • Jie Lai
    • Kun Chen
    • Tianling Ding
    • Yan Yuan
    • Yan Ma
    • Hui Kang
    • Zhiguang Lin
    • Ni Fan
    • Jingjing Ma
    • Qingchao Zeng
    • Xiaoping Xu
    • Qingping Wang
    • Bobin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Laboratory Medicine, Huashan Hospital North, Fudan University, Shanghai 200040, P.R. China, Department of Hematology, Huashan Hospital North, Fudan University, Shanghai 200040, P.R. China
  • Pages: 397-404
    |
    Published online on: October 11, 2018
       https://doi.org/10.3892/or.2018.6781
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to prospectively evaluate the recurrence and survival outcome of primary central nervous system lymphoma (PCNSL) with intraocular involvement. For this purpose, a prospective cohort of 103 pathologically confirmed patients with PCNSL was enrolled in this study. Ophthalmologic examinations were performed both at diagnosis and during follow‑up. The patients with PCNSL with suspected intraocular involvement underwent vitrectomy for confirmation. Patients who presented with intraocular involvement either at diagnosis or during disease progression were allocated to the intraocular lymphoma (IOL) group. All patients with PCNSL received systemic methotrexate (MTX)‑based chemotherapy with or without radiotherapy. MTX intravitreal injection combined with systemic MTX‑based chemotherapy was recommended once ocular lesions were confirmed. Recurrent intraocular and central nervous system (CNS) events, progression‑free survival (PFS) and overall survival (OS) outcomes were analyzed. The findings of this study revealed that 21 patients with PCNSL exhibited intraocular involvement. One patient with IOL presented with isolated ocular lymphoma at the initial diagnosis, and the others presented with ocular involvement along with CNS invasion during the course of the disease. A total of 14 patients received systemic MTX‑based chemotherapy prior to the diagnosis of IOL. The recurrence rates in patients with or without intraocular involvement were 71.4 and 46.3%, respectively (P=0.04) and the relapse sites in the patients with IOL included the brain (3 patients), eyes (6 patients), and both brain and eyes (6 cases). The median PFS was 13 months in the IOL group and 19 months in the patients without intraocular involvement (non‑IOL) (P=0.019). The median OS was 51 months vs. 56 months, respectively (P=0.312). There was no significant difference in the 2‑year PFS and OS rates between the 2 groups (23.8% vs. 23.2%, P=0.951; and 61.9% vs. 41.4%, P=0.093, respectively). On the whole, the findings of this study suggest that patients with IOL have a high risk of relapse and a poor PFS compared to patients without IOL, but a similar OS.
View Figures

Figure 1

Figure 2

View References

1 

Abrey LE, Batchelor TT, Ferreri AJ, Gospodarowicz M, Pulczynski EJ, Zucca E, Smith JR, Korfel A, Soussain C, DeAngelis LM, et al: Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol. 23:pp. 5034–5043. 2005, View Article : Google Scholar : PubMed/NCBI

2 

Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, et al: Primary vitreoretinal lymphoma: A report from an international primary central nervous system lymphoma collaborative group symposium. Oncologist. 16:1589–1599. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Peterson K, Gordon KB, Heinemann MH and DeAngelis LM: The clinical spectrum of ocular lymphoma. Cancer-Am Cancer Soc. 72:843–849. 1993.

4 

Nussenblatt RB, Chan CC, Wilson WH, Hochman J and Gottesman M: International Central Nervous System and Ocular Lymphoma Workshop: Recommendations for the future. Ocul Immunol Inflamm. 14:139–144. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Sung CO, Kim SC, Karnan S, Karube K, Shin HJ, Nam DH, Suh YL, Kim SH, Kim JY, Kim SJ, et al: Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma. Blood. 117:1291–1300. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Kim MM, Dabaja BS, Medeiros J, Kim S, Allen P, Chevez-Barrios P, Gombos DS and Fowler N: Survival outcomes of primary intraocular lymphoma: A single-institution experience. Am J Clin Oncol. 39:109–113. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Wang L, Sato-Otsubo A, Sugita S, Takase H, Mochizuki M, Usui Y, Goto H, Koyama T, Akiyama H, Miura O, et al: High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays. Cancer Sci. 105:592–599. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Mulay K, Narula R and Honavar SG: Primary vitreoretinal lymphoma. Indian J Ophthalmol. 63:180–186. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Witmer MT: Primary vitreoretinal lymphoma: Management of isolated ocular disease. Cancer Control. 23:110–116. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Stubiger N, Kakkassery V, Gundlach E, Winterhalter S and Pleyer U: Diagnostics and treatment of primary vitreoretinal lymphoma. Ophthalmologe. 112:223–230. 2015.(In German). View Article : Google Scholar : PubMed/NCBI

11 

Rajagopal R and Harbour JW: Diagnostic testing and treatment choices in primary vitreoretinal lymphoma. Retina. 31:435–440. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Cho BJ, Kim DY, Park UC, Lee JY, Yoon YH and Yu HG: Clinical features and treatment outcomes of vitreoretinal lymphoma according to its association with CNS lymphoma. Ocul Immunol Inflamm. 26:365–371. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Ahle G, Touitou V, Cassoux N, Bouyon M, Humbrecht C, Oesterlé H, Baraniskin A, Soussain C, Nguyen-Them L, Gaultier C, et al: Optic nerve infiltration in primary central nervous system lymphoma. Jama Neurol. 74:1368–1373. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Grimm SA, McCannel CA, Omuro AM, Ferreri AJ, Blay JY, Neuwelt EA, Siegal T, Batchelor T, Jahnke K, Shenkier TN, et al: Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report. Neurology. 71:pp. 1355–1360. 2008, View Article : Google Scholar : PubMed/NCBI

15 

Kreher S, Strehlow F, Martus P, Roth P, Hertenstein B, Röth A, Birnbaum T, Griesinger F, Rauch M, Kanz L, et al: Prognostic impact of intraocular involvement in primary CNS lymphoma: Experience from the G-PCNSL-SG1 trial. Ann Hematol. 94:409–414. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Jahnke K, Korfel A, Komm J, Bechrakis NE, Stein H, Thiel E and Coupland SE: Intraocular lymphoma 2000–2005: Results of a retrospective multicentre trial. Graefes Arch Clin Exp Ophthalmol. 244:663–669. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Kaburaki T, Taoka K, Matsuda J, Yamashita H, Matsuda I, Tsuji H, Tanaka R, Nakazaki K, Nakamura F, Kamiya K, et al: Combined intravitreal methotrexate and immunochemotherapy followed by reduced-dose whole-brain radiotherapy for newly diagnosed B-cell primary intraocular lymphoma. Br J Haematol. 179:246–255. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Langner-Lemercier S, Houillier C, Soussain C, Ghesquières H, Chinot O, Taillandier L, Soubeyran P, Lamy T, Morschhauser F, Benouaich-Amiel A, et al: Primary CNS lymphoma at first relapse/progression: Characteristics, management, and outcome of 256 patients from the French LOC network. Neuro Oncol. 18:1297–1303. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Nayak L, Hedvat C, Rosenblum MK, Abrey LE and DeAngelis LM: Late relapse in primary central nervous system lymphoma: Clonal persistence. Neuro Oncol. 13:525–529. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kim JE, Yoon DH, Kim S, Lee DH, Kim JH, Yoon YH, Chi HS, Lee SW, Park CS, Huh J and Suh C: Relapse pattern and prognostic factors for patients with primary central nervous system lymphoma. Korean J Hematol. 47:60–66. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ferreri AJ, Blay JY, Reni M, Pasini F, Gubkin A, Tirelli U, Calderoni A, Zucca E, Cortelazzo S, Chassagne C, et al: Relevance of intraocular involvement in the management of primary central nervous system lymphomas. Ann Oncol. 13:531–538. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Fend F, Ferreri AJ and Coupland SE: How we diagnose and treat vitreoretinal lymphoma. Br J Haematol. 173:680–692. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Coupland SE, Bechrakis NE, Anastassiou G, Foerster AM, Heiligenhaus A, Pleyer U, Hummel M and Stein H: Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. Graefes Arch Clin Exp Ophthalmol. 241:860–870. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Sugita S, Takase H, Sugamoto Y, Arai A, Miura O and Mochizuki M: Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. JPN J Ophthalmol. 53:209–214. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Chan CC, Whitcup SM, Solomon D and Nussenblatt RB: Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. Am J Ophthalmol. 120:671–673. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Cho BJ and Yu HG: Risk factors for intraocular involvement in patients with primary central nervous system lymphoma. J Neurooncol. 120:523–529. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Akiyama H, Takase H, Kubo F, Miki T, Yamamoto M, Tomita M, Mochizuki M, Miura O and Arai A: High-dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma. Cancer Sci. 107:1458–1464. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Frenkel S, Hendler K, Siegal T, Shalom E and Pe'Er J: Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience. Br J Ophthalmol. 92:383–388. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Isobe K, Ejima Y, Tokumaru S, Shikama N, Suzuki G, Takemoto M, Tsuchida E, Nomura M, Shibamoto Y and Hayabuchi N: Treatment of primary intraocular lymphoma with radiation therapy: A multi-institutional survey in Japan. Leuk Lymphoma. 47:1800–1805. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Tropinskaya OF, Vetlova ER, Serova NK, Golanov AV and Fil'Chenkova NA: Radiotherapy of primary intraocular lymphoma associated with primary central nervous system lymphoma. Zh Vopr Neirokhir Im N N Burdenko. 80:74–81. 2016.(In English, Russian). View Article : Google Scholar : PubMed/NCBI

31 

Berenbom A, Davila RM, Lin HS and Harbour JW: Treatment outcomes for primary intraocular lymphoma: Implications for external beam radiotherapy. Eye. 21:1198–1201. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhuang L, Lai J, Chen K, Ding T, Yuan Y, Ma Y, Kang H, Lin Z, Fan N, Ma J, Ma J, et al: Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma. Oncol Rep 41: 397-404, 2019.
APA
Zhuang, L., Lai, J., Chen, K., Ding, T., Yuan, Y., Ma, Y. ... Chen, B. (2019). Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma. Oncology Reports, 41, 397-404. https://doi.org/10.3892/or.2018.6781
MLA
Zhuang, L., Lai, J., Chen, K., Ding, T., Yuan, Y., Ma, Y., Kang, H., Lin, Z., Fan, N., Ma, J., Zeng, Q., Xu, X., Wang, Q., Chen, B."Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma". Oncology Reports 41.1 (2019): 397-404.
Chicago
Zhuang, L., Lai, J., Chen, K., Ding, T., Yuan, Y., Ma, Y., Kang, H., Lin, Z., Fan, N., Ma, J., Zeng, Q., Xu, X., Wang, Q., Chen, B."Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma". Oncology Reports 41, no. 1 (2019): 397-404. https://doi.org/10.3892/or.2018.6781
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang L, Lai J, Chen K, Ding T, Yuan Y, Ma Y, Kang H, Lin Z, Fan N, Ma J, Ma J, et al: Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma. Oncol Rep 41: 397-404, 2019.
APA
Zhuang, L., Lai, J., Chen, K., Ding, T., Yuan, Y., Ma, Y. ... Chen, B. (2019). Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma. Oncology Reports, 41, 397-404. https://doi.org/10.3892/or.2018.6781
MLA
Zhuang, L., Lai, J., Chen, K., Ding, T., Yuan, Y., Ma, Y., Kang, H., Lin, Z., Fan, N., Ma, J., Zeng, Q., Xu, X., Wang, Q., Chen, B."Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma". Oncology Reports 41.1 (2019): 397-404.
Chicago
Zhuang, L., Lai, J., Chen, K., Ding, T., Yuan, Y., Ma, Y., Kang, H., Lin, Z., Fan, N., Ma, J., Zeng, Q., Xu, X., Wang, Q., Chen, B."Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma". Oncology Reports 41, no. 1 (2019): 397-404. https://doi.org/10.3892/or.2018.6781
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team