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Article

Anticancer activity of gomisin J from Schisandra chinensis fruit

  • Authors:
    • Samil Jung
    • Hyung-In Moon
    • Subeen Kim
    • Nguyen Thi Ngoc Quynh
    • Jimin Yu
    • Zolzaya Sandag
    • Dan-Diem Thi Le
    • Hyegyeong Lee
    • Hyojeong Lee
    • Myeong-Sok Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea
  • Pages: 711-717
    |
    Published online on: November 2, 2018
       https://doi.org/10.3892/or.2018.6850
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Abstract

In attempting to identify effective anticancer drugs from natural products that are harmless to humans, we found that the gomisin J from Schisandra chinensis fruit has anticancer activity. Schisandra chinensis fruits are used in traditional herbal medicine and gomisin J is one of their chemical constituents. In the present study, we examined the anticancer activity of gomisin J in MCF7 and MDA-MB-231 breast cancer cell lines and in MCF10A normal cell line, in a time- and concentration-dependent manner. Our data revealed that gomisin J exerted a much stronger cytotoxic effect on MCF7 and MDA-MB-231 cancer cells than on MCF10A normal cells. Gomisin J suppressed the proliferation and decreased the viability of MCF7 and MDA-MB-231 cells at relatively low (<10 µg/ml) and high (>30 µg/ml) concentrations, respectively. Our data also revealed that gomisin J induced necroptosis, a programmed form of necrosis, as well as apoptosis. Notably, gomisin J predominantly induced necroptosis in MCF7 cells that are known to have high resistance to many pro-apoptotic anticancer drugs, while MDA-MB-231 exhibited a much lower level of necroptosis but instead a higher level of apoptosis. This data indicated the possibility that it may be used as a more effective anticancer drug, especially in apoptosis-resistant malignant cancer cells. In an extended study, gomisin J exhibited a strong cytotoxic effect on all tested various types of 13 cancer cell lines, indicating its potential to be used against a wide range of different types of cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Jung S, Moon H, Kim S, Quynh NT, Yu J, Sandag Z, Le DT, Lee H, Lee H, Lee M, Lee M, et al: Anticancer activity of gomisin J from Schisandra chinensis fruit. Oncol Rep 41: 711-717, 2019.
APA
Jung, S., Moon, H., Kim, S., Quynh, N.T., Yu, J., Sandag, Z. ... Lee, M. (2019). Anticancer activity of gomisin J from Schisandra chinensis fruit. Oncology Reports, 41, 711-717. https://doi.org/10.3892/or.2018.6850
MLA
Jung, S., Moon, H., Kim, S., Quynh, N. T., Yu, J., Sandag, Z., Le, D. T., Lee, H., Lee, H., Lee, M."Anticancer activity of gomisin J from Schisandra chinensis fruit". Oncology Reports 41.1 (2019): 711-717.
Chicago
Jung, S., Moon, H., Kim, S., Quynh, N. T., Yu, J., Sandag, Z., Le, D. T., Lee, H., Lee, H., Lee, M."Anticancer activity of gomisin J from Schisandra chinensis fruit". Oncology Reports 41, no. 1 (2019): 711-717. https://doi.org/10.3892/or.2018.6850
Copy and paste a formatted citation
x
Spandidos Publications style
Jung S, Moon H, Kim S, Quynh NT, Yu J, Sandag Z, Le DT, Lee H, Lee H, Lee M, Lee M, et al: Anticancer activity of gomisin J from Schisandra chinensis fruit. Oncol Rep 41: 711-717, 2019.
APA
Jung, S., Moon, H., Kim, S., Quynh, N.T., Yu, J., Sandag, Z. ... Lee, M. (2019). Anticancer activity of gomisin J from Schisandra chinensis fruit. Oncology Reports, 41, 711-717. https://doi.org/10.3892/or.2018.6850
MLA
Jung, S., Moon, H., Kim, S., Quynh, N. T., Yu, J., Sandag, Z., Le, D. T., Lee, H., Lee, H., Lee, M."Anticancer activity of gomisin J from Schisandra chinensis fruit". Oncology Reports 41.1 (2019): 711-717.
Chicago
Jung, S., Moon, H., Kim, S., Quynh, N. T., Yu, J., Sandag, Z., Le, D. T., Lee, H., Lee, H., Lee, M."Anticancer activity of gomisin J from Schisandra chinensis fruit". Oncology Reports 41, no. 1 (2019): 711-717. https://doi.org/10.3892/or.2018.6850
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