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Article

IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes

  • Authors:
    • Bartlomiej E. Krazinski
    • Anna E. Kowalczyk
    • Agnieszka Sliwinska‑Jewsiewicka
    • Jedrzej Grzegrzolka
    • Janusz Godlewski
    • Przemyslaw Kwiatkowski
    • Piotr Dziegiel
    • Zbigniew Kmiec
    • Jolanta Kiewisz
  • View Affiliations / Copyright

    Affiliations: Department of Human Histology and Embryology, University of Warmia and Mazury in Olsztyn, 10‑082 Olsztyn, Poland, Department of Human Morphology and Embryology, Division of Histology and Embryology, Wroclaw Medical University, 50‑368 Wroclaw, Poland
  • Pages: 1189-1197
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/or.2018.6872
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Abstract

Inhibitor of nuclear factor kappa B kinase subunit B (IKBKB or IKKβ) is a key activator of the nuclear factor κB transcription factor pathway. Increased expression and/or aberrant activity of IKBKB have been observed in various types of human cancer. Three independent techniques, reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry, were used to demonstrate that IKBKB expression is decreased in clear cell renal cell carcinoma (ccRCC). Notably, the patients with upregulated IKBKB protein expression were characterized by higher nuclear grade tumors and significantly shorter survival. The findings indicate that IKBKB protein may be of clinical relevance in ccRCC, serving as a marker of poor prognosis and as potential target for adjuvant chemotherapies. Further studies are required to validate the prognostic and predictive value of IKBKB.
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Copy and paste a formatted citation
Spandidos Publications style
Krazinski BE, Kowalczyk AE, Sliwinska‑Jewsiewicka A, Grzegrzolka J, Godlewski J, Kwiatkowski P, Dziegiel P, Kmiec Z and Kiewisz J: IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes. Oncol Rep 41: 1189-1197, 2019.
APA
Krazinski, B.E., Kowalczyk, A.E., Sliwinska‑Jewsiewicka, A., Grzegrzolka, J., Godlewski, J., Kwiatkowski, P. ... Kiewisz, J. (2019). IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes. Oncology Reports, 41, 1189-1197. https://doi.org/10.3892/or.2018.6872
MLA
Krazinski, B. E., Kowalczyk, A. E., Sliwinska‑Jewsiewicka, A., Grzegrzolka, J., Godlewski, J., Kwiatkowski, P., Dziegiel, P., Kmiec, Z., Kiewisz, J."IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes". Oncology Reports 41.2 (2019): 1189-1197.
Chicago
Krazinski, B. E., Kowalczyk, A. E., Sliwinska‑Jewsiewicka, A., Grzegrzolka, J., Godlewski, J., Kwiatkowski, P., Dziegiel, P., Kmiec, Z., Kiewisz, J."IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes". Oncology Reports 41, no. 2 (2019): 1189-1197. https://doi.org/10.3892/or.2018.6872
Copy and paste a formatted citation
x
Spandidos Publications style
Krazinski BE, Kowalczyk AE, Sliwinska‑Jewsiewicka A, Grzegrzolka J, Godlewski J, Kwiatkowski P, Dziegiel P, Kmiec Z and Kiewisz J: IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes. Oncol Rep 41: 1189-1197, 2019.
APA
Krazinski, B.E., Kowalczyk, A.E., Sliwinska‑Jewsiewicka, A., Grzegrzolka, J., Godlewski, J., Kwiatkowski, P. ... Kiewisz, J. (2019). IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes. Oncology Reports, 41, 1189-1197. https://doi.org/10.3892/or.2018.6872
MLA
Krazinski, B. E., Kowalczyk, A. E., Sliwinska‑Jewsiewicka, A., Grzegrzolka, J., Godlewski, J., Kwiatkowski, P., Dziegiel, P., Kmiec, Z., Kiewisz, J."IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes". Oncology Reports 41.2 (2019): 1189-1197.
Chicago
Krazinski, B. E., Kowalczyk, A. E., Sliwinska‑Jewsiewicka, A., Grzegrzolka, J., Godlewski, J., Kwiatkowski, P., Dziegiel, P., Kmiec, Z., Kiewisz, J."IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes". Oncology Reports 41, no. 2 (2019): 1189-1197. https://doi.org/10.3892/or.2018.6872
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