Open Access

ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer

  • Authors:
    • Lili Guo
    • Lili Ma
    • Chao Liu
    • Yan Lei
    • Na Tang
    • Yingxin Huang
    • Guan Huang
    • Dazhou Li
    • Qi Wang
    • Guanglong Liu
    • Minshan Tang
    • Zhiliang Jing
    • Yongjian Deng
  • View Affiliations

  • Published online on: December 19, 2018     https://doi.org/10.3892/or.2018.6943
  • Pages: 1603-1615
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endoplasmic reticulum protein 29 (ERp29), an endoplasmic reticulum (ER) protein, participates in ER stress (ERS), but little is known about the association of ERp29 with ERS in the metastasis and prognosis of cancerous diseases. The present study revealed that ERp29 was important to ERS and interfered with the malignant behaviors of colorectal cancer (CRC). Experiments in in vitro and in animal models revealed that ERS inhibited the cell growth and suppressed the metastatic capacity of CRC cells, but ERp29 counteracted these effects. Furthermore, it was demonstrated that ERp29 recovered the migration and metastatic behaviors of CRC cells suppressed by ERS, mediated only when it combined with cullin5 (CUL5). ERp29 also relied on CUL5 to promote epithelial‑mesenchymal transition. From the immunohistochemical examination of CRC tissues, the high expression of ERp29 was revealed to predict the poor prognosis of 457 CRC cases. The retrospective analysis of the clinicopathological data of patients with CRC was consistent with the results of the in vitro and in vivo experiments. Thus, ERp29 protected CRC cells from ERS‑mediated reduction of malignancy to promote metastasis and may be a potential target of medical intervention for CRC therapy.
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March-2019
Volume 41 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Guo L, Ma L, Liu C, Lei Y, Tang N, Huang Y, Huang G, Li D, Wang Q, Liu G, Liu G, et al: ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer. Oncol Rep 41: 1603-1615, 2019
APA
Guo, L., Ma, L., Liu, C., Lei, Y., Tang, N., Huang, Y. ... Deng, Y. (2019). ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer. Oncology Reports, 41, 1603-1615. https://doi.org/10.3892/or.2018.6943
MLA
Guo, L., Ma, L., Liu, C., Lei, Y., Tang, N., Huang, Y., Huang, G., Li, D., Wang, Q., Liu, G., Tang, M., Jing, Z., Deng, Y."ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer". Oncology Reports 41.3 (2019): 1603-1615.
Chicago
Guo, L., Ma, L., Liu, C., Lei, Y., Tang, N., Huang, Y., Huang, G., Li, D., Wang, Q., Liu, G., Tang, M., Jing, Z., Deng, Y."ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer". Oncology Reports 41, no. 3 (2019): 1603-1615. https://doi.org/10.3892/or.2018.6943