|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Tran GD, Sun XD, Abnet CC, Fan JH, Dawsey
SM, Dong ZW, Mark SD, Qiao YL and Taylor PR: Prospective study of
risk factors for esophageal and gastric cancers in the Linxian
general population trial cohort in China. Int J Cancer.
113:456–463. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ando N, Kato H, Igaki H, Shinoda M, Ozawa
S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, et al: A
randomized trial comparing postoperative adjuvant chemotherapy with
cisplatin and 5-fluorouracil versus preoperative chemotherapy for
localized advanced squamous cell carcinoma of the thoracic
esophagus (JCOG9907). Ann Surg Oncol. 19:68–74. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Yu EH, Tu HF, Wu CH, Yang CC and Chang KW:
MicroRNA-21 promotes perineural invasion and impacts survival in
patients with oral carcinoma. J Chin Med Assoc. 80:383–388. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Teoh SL and Das S: The role of microRNAs
in diagnosis, prognosis, metastasis and resistant cases in breast
cancer. Curr Pharm Des. 23:1845–1859. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Tseng HH, Tseng YK, You JJ, Kang BH, Wang
TH, Yang CM, Chen HC, Liou HH, Liu PF, Ger LP, et al:
Next-generation sequencing for microRNA profiling: MicroRNA-21-3p
promotes oral cancer metastasis. Anticancer Res. 37:1059–1066.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Cao J, Liu J, Xu R, Zhu X, Liu L and Zhao
X: MicroRNA-21 stimulates epithelial-to-mesenchymal transition and
tumorigenesis in clear cell renal cells. Mol Med Rep. 13:75–82.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Li P, Mao WM, Zheng ZG, Dong ZM and Ling
ZQ: Down-regulation of PTEN expression modulated by dysregulated
miR-21 contributes to the progression of esophageal cancer. Dig Dis
Sci. 58:3483–3493. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Shen KH, Hung JH, Chang CW, Weng YT, Wu MJ
and Chen PS: Solasodine inhibits invasion of human lung cancer cell
through downregulation of miR-21 and MMPs expression. Chem Biol
Interact. 268:129–135. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Chen Z, Yu T, Cabay RJ, Jin Y, Mahjabeen
I, Luan X, Huang L, Dai Y and Zhou X: miR-486-3p, miR-139-5p, and
miR-21 as biomarkers for the detection of oral tongue squamous cell
carcinoma. Biomark Cancer. 9:1–8. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Mei LL, Qiu YT, Zhang B and Shi ZZ:
MicroRNAs in esophageal squamous cell carcinoma: Potential
biomarkers and therapeutic targets. Cancer Biomark. 19:1–9. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
He Y, Jin J, Wang L, Hu Y, Liang D, Yang
H, Liu Y and Shan B: Evaluation of miR-21 and miR-375 as prognostic
biomarkers in oesophageal cancer in high-risk areas in China. Clin
Exp Metastasis. 34:73–84. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Han JG, Jiang YD, Zhang CH, Yang YM, Pang
D, Song YN and Zhang GQ: A novel panel of serum
miR-21/miR-155/miR-365 as a potential diagnostic biomarker for
breast cancer. Ann Surg Treat Res. 92:55–66. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Markou A, Zavridou M and Lianidou ES:
miRNA-21 as a novel therapeutic target in lung cancer. Lung Cancer.
7:19–27. 2016.PubMed/NCBI
|
|
15
|
Dong J, Zhang Z, Gu T, Xu SF, Dong LX, Li
X, Fu BH and Fu ZZ: The role of microRNA-21 in predicting brain
metastases from non-small cell lung cancer. Onco Targets Ther.
10:185–194. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Ren J, Kuang TH, Chen J, Yang JW and Liu
YX: The diagnostic and prognostic values of microRNA-21 in patients
with gastric cancer: A meta-analysis. Eur Rev Med Pharmacol Sci.
21:120–130. 2017.PubMed/NCBI
|
|
17
|
Arantes LM, Laus AC, Melendez ME, de
Carvalho AC, Sorroche BP, De Marchi PR, Evangelista AF,
Scapulatempo-Neto C, de Souza Viana L and Carvalho AL: MiR-21 as
prognostic biomarker in head and neck squamous cell carcinoma
patients undergoing an organ preservation protocol. Oncotarget.
8:9911–9921. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yang Y, Guo JX and Shao ZQ: miR-21 targets
and inhibits tumor suppressor gene PTEN to promote prostate cancer
cell proliferation and invasion: An experimental study. Asian Pac J
Trop Med. 10:87–91. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Huo W, Zhao G, Yin J, Ouyang X, Wang Y,
Yang C, Wang B, Dong P, Wang Z, Watari H, et al: Lentiviral
CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the
epithelial to mesenchymal transition in ovarian cancer cells. J
Cancer. 8:57–64. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Liu CH, Huang Q, Jin ZY, Zhu CL and Liu
Zand Wang C: miR-21 and KLF4 jointly augment epithelial-mesenchymal
transition via the Akt/ERK1/2 pathway. Int J Oncol. 50:1109–1115.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Li C, Song L, Zhang Z, Bai XX, Cui MF and
Ma LJ: MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal
transition in gastric cancer through up-regulating PTEN expression.
Oncotarget. 7:66989–67003. 2016.PubMed/NCBI
|
|
22
|
Yan L, Cao R, Liu Y, Wang L, Pan B, Lv X,
Jiao H, Zhuang Q, Sun X and Xiao R: MiR-21-5p links
epithelial-mesenchymal transition phenotype with stem-like cell
signatures via AKT signaling in keloid keratinocytes. Sci Rep.
6:282812016. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Sun SS, Zhou X, Huang YY, Kong LP, Mei M,
Guo WY, Zhao MH, Ren Y, Shen Q and Zhang L: Targeting STAT3/miR-21
axis inhibits epithelial-mesenchymal transition via regulating CDK5
in head and neck squamous cell carcinoma. Mol Cancer. 14:2132015.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wu ZH, Tao ZH, Zhang J, Li T, Ni C, Xie J,
Zhang JF and Hu XC: MiRNA-21 induces epithelial to mesenchymal
transition and gemcitabine resistance via the PTEN/AKT pathway in
breast cancer. Tumour Biol. 37:7245–7254. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Liu Z, Jin ZY, Liu CH, Xie F, Lin XS and
Huang Q: MicroRNA-21 regulates biological behavior by inducing EMT
in human cholangiocarcinoma. Int J Clin Exp Pathol. 8:4684–4694.
2015.PubMed/NCBI
|
|
26
|
Bornachea O, Santos M, Martínez-Cruz AB,
García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago
A, Saiz-Ladera C, et al: EMT and induction of miR-21 mediate
metastasis development in Trp53-deficient tumours. Sci Rep.
2:4342012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Han M, Wang Y, Liu M, Bi X, Bao J, Zeng N,
Zhu Z, Mo Z, Wu C and Chen X: MiR-21 regulates
epithelial-mesenchymal transition phenotype and hypoxia-inducible
factor-1alpha expression in third-sphere forming breast cancer stem
cell-like cells. Cancer Sci. 103:1058–1064. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Mathé EA, Nguyen GH, Bowman ED, Zhao Y,
Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, et
al: MicroRNA expression in squamous cell carcinoma and
adenocarcinoma of the esophagus: Associations with survival. Clin
Cancer Res. 15:6192–6200. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2ΔΔCT method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Winther M, Alsner J, Tramm T, Baeksgaard
L, Holtved E and Nordsmark M: Evaluation of miR-21 and miR-375 as
prognostic biomarkers in esophageal cancer. Acta Oncol.
54:1582–1591. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Lv H, He Z, Wang H, Du T and Pang Z:
Differential expression of miR-21 and miR-75 in esophageal
carcinoma patients and its clinical implication. Am J Transl Res.
8:3288–3298. 2016.PubMed/NCBI
|
|
32
|
Sheikh AM, Small HY, Currie G and Delles
C: Systematic review of Micro-RNA expression in pre-eclampsia
identifies a number of common pathways associated with the disease.
PLoS One. 11:e01608082016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yan LX, Liu YH, Xiang JW, Wu QN, Xu LB,
Luo XL, Zhu XL, Liu C, Xu FP, Luo DL, et al: PIK3R1 targeting by
miR-21 suppresses tumor cell migration and invasion by reducing
PI3K/AKT signaling and reversing EMT, and predicts clinical outcome
of breast cancer. Int J Oncol. 48:471–484. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Cufi S, Bonavia R, Vazquez-Martin A,
Oliveras-Ferraros C, Corominas-Faja B, Cuyàs E, Martin-Castillo B,
Barrajón- Catalán E, Visa J, Segura-Carretero A, et al: Silibinin
suppresses EMT-driven erlotinib resistance by reversing the high
miR-21/low miR-200c signature in vivo. Sci Rep.
3:24592013. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Han M, Liu M, Wang Y, Chen X, Xu J, Sun Y,
Zhao L, Qu H, Fan Y and Wu C: Antagonism of miR-21 reverses
epithelial-mesenchymal transition and cancer stem cell phenotype
through AKT/ERK1/2 inactivation by targeting PTEN. PLoS One.
7:e395202012. View Article : Google Scholar : PubMed/NCBI
|
