Open Access

Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis

  • Authors:
    • Tingting Huang
    • Hongming Zhang
    • Xiyong Wang
    • Lu Xu
    • Jinfang Jia
    • Xiaoli Zhu
  • View Affiliations

  • Published online on: December 21, 2018     https://doi.org/10.3892/or.2018.6950
  • Pages: 1700-1706
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gambogenic acid (GNA), which is an important active compound present in gamboge, exerts anticancer activity in various types of tumor cells. However, the effect of GNA on small‑cell lung cancer (SCLC) cell lines and the underlying mechanism involved still remain unclear. In the present study, GNA inhibited the proliferation and cell cycle progression of SCLC cells. GNA also promoted the apoptosis of SCLC cells in a dose‑dependent manner, which is associated with modulating the levels of proteins involved in apoptosis pathways in NCI‑H446 and NCI‑H1688 cells. The results demonstrated that GNA increased the level of cleaved caspase‑3, ‑8 and ‑9, and Bax but decreased the expression of anti‑apoptotic protein, Bcl‑2. Furthermore, similar results were obtained in a mouse tumor xenograft model. Additionally, GNA exhibit low toxicity in tissues when administered to mice in the SCLC xenograft models. Collectively, our findings demonstrated that GNA significantly inhibited the proliferation of SCLC cells and promoted cell apoptosis via cell cycle arrest and induction of apoptosis.
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March-2019
Volume 41 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Huang T, Zhang H, Wang X, Xu L, Jia J and Zhu X: Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis. Oncol Rep 41: 1700-1706, 2019
APA
Huang, T., Zhang, H., Wang, X., Xu, L., Jia, J., & Zhu, X. (2019). Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis. Oncology Reports, 41, 1700-1706. https://doi.org/10.3892/or.2018.6950
MLA
Huang, T., Zhang, H., Wang, X., Xu, L., Jia, J., Zhu, X."Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis". Oncology Reports 41.3 (2019): 1700-1706.
Chicago
Huang, T., Zhang, H., Wang, X., Xu, L., Jia, J., Zhu, X."Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis". Oncology Reports 41, no. 3 (2019): 1700-1706. https://doi.org/10.3892/or.2018.6950