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Article

Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer

  • Authors:
    • Chyou‑Wei Wei
    • Yung‑Luen Yu
    • Yu‑Hsun Chen
    • Yu‑Ting Hung
    • Giou‑Teng Yiang
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C., Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan, R.O.C.
  • Pages: 2060-2066
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    Published online on: January 9, 2019
       https://doi.org/10.3892/or.2019.6958
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Abstract

Triple‑negative breast cancers (TNBCs) lack the estrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Therefore, hormone or targeted therapies are not effective in the treatment of TNBC and thus the development of novel therapeutic strategies is crucial. Methotrexate (MTX), a folate antagonist, has been used in the treatment of various types of cancer; however, the anticancer effects of MTX treatment on breast cancer have thus far been ineffective. Vitamin E variants and derivatives have been applied for cancer therapy. Previous studies have indicated that vitamin E variants and derivatives exert distinct anticancer effects on different types of cancer. However, whether MTX plus vitamin E variants or its derivatives can inhibit TNBC remains unclear. The aim of the present study was to examine the anticancer effects and mechanisms of action of MTX in combination with vitamin E variants (α‑tocopherol) and derivatives (α‑tocopherol succinate) on TNBC. In the present study, MTT assay and western blot analysis were used to determine the cell survival rates and protein levels. The results demonstrated that combination treatment with MTX and α‑tocopherol suppressed TNBC cell proliferation. In addition, various concentrations of MTX exerted distinct cytotoxic effects on α‑tocopherol succinate‑treated cells. Furthermore, high‑dose MTX enhanced α‑tocopherol succinate‑induced anticancer activity; however, low‑dose MTX inhibited α‑tocopherol succinate‑induced anticancer activity. The present study also demonstrated that caspase‑3 activation and poly(adenosine diphosphate‑ribose) polymerase cleavage were observed in the α‑tocopherol succinate/MTX‑treated cells. In conclusion, the findings of the present study demonstrated that high‑dose MTX enhanced anticancer activity in α‑TOS‑treated TNBC, while low‑dose MTX reduced anticancer activity in α‑TOS‑treated TNBC.
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View References

1 

Fan J, Wu Y, Yuan M, Page D, Liu J, Ong IM, Peissig P and Burnside E: Structure-leveraged methods in breast cancer risk prediction. J Mac Learn Res. 17:852017.

2 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Robinson SP and Jordan VC: Antiestrogenic action of toremifene on hormone-dependent, -independent, and heterogeneous breast tumor growth in the athymic mouse. Cancer Res. 49:1758–1762. 1989.PubMed/NCBI

4 

Wu CW, Liu HC, Yu YL, Hung YT, Wei CW and Yiang GT: Combined treatment with vitamin C and methotrexate inhibits triple-negative breast cancer cell growth by increasing H2O2 accumulation and activating caspase-3 and p38 pathways. Oncol Rep. 37:2177–2184. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC and Hung MC: Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. PLoS One. 8:e613622013. View Article : Google Scholar : PubMed/NCBI

6 

Metzger-Filho O, Tutt A, de Azambuja E, Saini KS, Viale G, Loi S, Bradbury I, Bliss JM, Azim HA Jr, Ellis P, et al: Dissecting the heterogeneity of triple-negative breast cancer. J Clin Oncol. 30:1879–1887. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Williams CB, Soloff AC, Ethier SP and Yeh ES: Perspectives on epidermal growth factor receptor regulation in triple-negative breast cancer: Ligand-mediated mechanisms of receptor regulation and potential for clinical targeting. Adv Cancer Res. 127:253–281. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Malaviya AN: Low-dose methotrexate (LD-MTX) in rheumatology practice-a most widely misunderstood drug. Curr Rheumatol Rev. 12:168–176. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Robien K, Boynton A and Ulrich CM: Pharmacogenetics of folate-related drug targets in cancer treatment. Pharmacogenomics. 6:673–689. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Mori S, Hidaka M, Kawakita T, Hidaka T, Tsuda H, Yoshitama T, Migita K and Ueki Y: Factors associated with myelosuppression related to low-dose methotrexate therapy for inflammatory rheumatic diseases. PLoS One. 11:e01547442016. View Article : Google Scholar : PubMed/NCBI

12 

Maejima H, Watarai A, Nakano T, Katayama C, Nishiyama H and Katsuoka K: Adverse effects of methotrexate in three psoriatic arthritis patients. Rheumatol Int. 34:571–574. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Kolli VK, Abraham P, Isaac B and Selvakumar D: Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage. Chemotherapy. 55:83–90. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Cağlar Y, Özgür H, Matur I, Yenilmez ED, Tuli A, GÖnlüşen G and Polat S: Ultrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats. Histol Histopathol. 28:865–874. 2013.PubMed/NCBI

15 

Yang W, Zou Y, Meng F, Zhang J, Cheng R, Deng C and Zhong Z: Efficient and targeted suppression of human lung tumor xenografts in mice with methotrexate sodium encapsulated in all-function-in-one chimeric polymersomes. Adv Mater. 28:8234–8239. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Larsen EC, Devidas M, Chen S, Salzer WL, Raetz EA, Loh ML, Mattano LA Jr, Cole C, Eicher A, Haugan M, et al: Dexamethasone and high-dose methotrexate improve outcome for children and young adults with high-risk B-acute lymphoblastic leukemia: A report from children's oncology group study AALL0232. J Clin Oncol. 34:2380–2388. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Kansara R, Shenkier TN, Connors JM, Sehn LH, Savage KJ, Gerrie AS and Villa D: Rituximab with high-dose methotrexate in primary central nervous system lymphoma. Am J Hematol. 90:1149–1154. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Cipolleschi MG, Marzi I, Rovida E, Olivotto M and Dello Sbarba P: Low-dose methotrexate enhances cycling of highly anaplastic cancer cells. Cell Cycle. 16:280–285. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Yiang GT, Chou PL, Hung YT, Chen JN, Chang WJ, Yu YL and Wei CW: Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells. Oncol Rep. 32:1057–1063. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Barros S, Mencia N, Rodriguez L, Oleaga C, Santos C, Noé V and Ciudad CJ: The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells. PLoS One. 8:e632762013. View Article : Google Scholar : PubMed/NCBI

21 

Tanabe M: Combination chemotherapy of mitomycin C and methotrexate was effective on metastatic breast cancer resistant to Eribulin, Vinorelbine, and bevacizumab after anthracycline, Taxane, and Capecitabine. Case Rep Oncol. 9:422–426. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Velthuis-te Wierik EJ, van den Berg H, Weststrate JA, van het Hof KH and de Graaf C: Consumption of reduced-fat products: Effects on parameters of anti-oxidative capacity. Eur J Clin Nutr. 50:214–219. 1996.PubMed/NCBI

23 

Smolarek AK, So JY, Burgess B, Kong AN, Reuhl K, Lin Y, Shih WJ, Li G, Lee MJ, Chen YK, et al: Dietary administration of δ- and γ-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer. Cancer Prev Res. 5:1310–1320. 2012. View Article : Google Scholar

24 

Constantinou C, Papas A and Constantinou AI: Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs. Int J Cancer. 123:739–752. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Smolarek AK and Suh N: Chemopreventive activity of vitamin E in breast cancer: A focus on γ- and δ-tocopherol. Nutrients. 3:962–986. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Zapata GL, Guajardo MH and Terrasa AM: The in vitro protective effect of alpha-tocopherol on oxidative injury in the dog retina. Vet J. 177:266–272. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Ekstrand-Hammarstrom B, Osterlund C, Lilliehöök B and Bucht A: Vitamin E down-modulates mitogen-activated protein kinases, nuclear factor-kappaB and inflammatory responses in lung epithelial cells. Clin Exp Immunol. 147:359–369. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Comitato R, Nesaretnam K, Leoni G, Ambra R, Canali R, Bolli A, Marino M and Virgili F: A novel mechanism of natural vitamin E tocotrienol activity: Involvement of ERbeta signal transduction. Am J Physiol Endocrinol Metab. 297:E427–E437. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Chamras H, Barsky SH, Ardashian A, Navasartian D, Heber D and Glaspy JA: Novel interactions of vitamin E and estrogen in breast cancer. Nutr Cancer. 52:43–48. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Gao Y, Qi X, Zheng Y, Ji H, Wu L, Zheng N and Tang J: Nanoemulsion enhances α-tocopherol succinate bioavailability in rats. Int J Pharm. 515:506–514. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Kulikov AV, Vdovin AS, Zhivotovsky B and Gogvadze V: Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment. Cell Mol Life Sci. 71:2325–2333. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Angulo-Molina A, Reyes-Leyva J, López-Malo A and Hernández J: The role of alpha tocopheryl succinate (α-TOS) as a potential anticancer agent. Nutr Cancer. 66:167–176. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Yu W, Liao QY, Hantash FM, Sanders BG and Kline K: Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res. 61:6569–6576. 2001.PubMed/NCBI

34 

Badr DM, Hafez HF, Agha AM and Shouman SA: The combination of α-tocopheryl succinate and sodium selenite on breast cancer: A merit or a demerit? Oxid Med Cell Longev 2016. 47416942016.

35 

Wang XF, Xie Y, Wang HG, Zhang Y, Duan XC and Lu ZJ: α-Tocopheryl succinate induces apoptosis in erbB2-expressing breast cancer cell via NF-κB pathway. Acta Pharmacol Sin. 31:1604–1610. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Wang D, Chuang HC, Weng SC, Huang PH, Hsieh HY, Kulp SK and Chen CS: alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. J Med Chem. 52:5642–5648. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Turley JM, Fu T, Ruscetti FW, Mikovits JA, Bertolette DC III and Birchenall-Roberts MC: Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. Cancer Res. 57:881–890. 1997.PubMed/NCBI

38 

Lin BR, Yu CJ, Chen WC, Lee HS, Chang HM, Lee YC, Chien CT and Chen CF: Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling. J Biomed Sci. 16:352009. View Article : Google Scholar : PubMed/NCBI

39 

Yiang GT, Yu YL, Lin KT, Chen JN, Chang WJ and Wei CW: Acetaminophen induces JNK/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells. Int J Mol Med. 36:485–492. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Abe N, Shimizu T, Miyoshi N, Murata Y and Nakamura Y: α-Tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate. Biosci Biotechnol Biochem. 76:381–383. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Abo-Haded HM, Elkablawy MA, Al-Johani Z, Al-Ahmadi O and El-Agamy DS: Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity. PLoS One. 12:e01742952017. View Article : Google Scholar : PubMed/NCBI

42 

Peh HY, Tan WS, Liao W and Wong WS: Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol. Pharmacol Ther. 162:152–169. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Yüncü M, Bükücü N, Bayat N, Sencar L and Tarakcioglu M: The effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis. Turk J Med Sci. 45:517–525. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Pyrhönen S, Kuitunen T, Nyandoto P and Kouri M: Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer. Br J Cancer. 71:587–591. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Drago JR, Nesbitt JA, Badalament RA and Smith J: Chemotherapy and vitamin E in treatment of Nb rat prostate tumors. In Vivo. 2:399–401. 1988.PubMed/NCBI

46 

Fu JY, Htar TT, De Silva L, Tan DM and Chuah LH: Chromatographic separation of vitamin E enantiomers. Molecules. 22(pii): E2332017. View Article : Google Scholar : PubMed/NCBI

47 

Dias MF, Sousa E, Cabrita S, Patricio J and Oliveira CF: Chemoprevention of DMBA-induced mammary tumors in rats by a combined regimen of alpha-tocopherol, selenium, and ascorbic acid. Breast J. 6:14–19. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Yiang GT, Chen JN, Lin PS, Liu HC, Chen SY and Wei CW: Combined treatment with vitamin E and gefitinib has synergistic effects to inhibit TGF-β1-induced renal fibroblast proliferation. Mol Med Rep. 13:5372–5378. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Uchihara Y, Ueda F, Tago K, Nakazawa Y, Ohe T, Mashino T, Yokota S, Kasahara T, Tamura H and Funakoshi-Tago M: Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK. PLoS One. 12:e01830032017. View Article : Google Scholar : PubMed/NCBI

50 

Peralta EA, Viegas ML, Louis S, Engle DL and Dunnington GL: Effect of vitamin E on tamoxifen-treated breast cancer cells. Surgery. 140:607–615. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Chang H, Li C, Huo K, Wang Q, Lu L, Zhang Q, Wang Y and Wang W: Luteolin prevents H2O2-induced apoptosis in H9C2 cells through modulating Akt-P53/Mdm2 signaling pathway. Biomed Res Int 2016. 51258362016.

52 

Miyazato H, Taira J and Ueda K: Hydrogen peroxide derived from marine peroxy sesquiterpenoids induces apoptosis in HCT116 human colon cancer cells. Bioorg Med Chem Lett. 26:4641–4644. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Wang C, Wang G, Liu H and Hou YL: Protective effect of bioactive compounds from Lonicera japonica Thunb. Against H2O2-induced cytotoxicity using neonatal rat cardiomyocytes. Iran J Basic Med Sci. 19:97–105. 2016.PubMed/NCBI

54 

ElAttar TM and Virji AS: Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents. Prostaglandins Leukot Essent Fatty Acids. 56:461–465. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Alleva R, Benassi MS, Pazzaglia L, Tomasetti M, Gellert N, Borghi B, Neuzil J and Picci P: Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis. Cancer Lett. 232:226–235. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei CW, Yu YL, Chen YH, Hung YT and Yiang GT: Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer. Oncol Rep 41: 2060-2066, 2019.
APA
Wei, C., Yu, Y., Chen, Y., Hung, Y., & Yiang, G. (2019). Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer. Oncology Reports, 41, 2060-2066. https://doi.org/10.3892/or.2019.6958
MLA
Wei, C., Yu, Y., Chen, Y., Hung, Y., Yiang, G."Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer". Oncology Reports 41.3 (2019): 2060-2066.
Chicago
Wei, C., Yu, Y., Chen, Y., Hung, Y., Yiang, G."Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer". Oncology Reports 41, no. 3 (2019): 2060-2066. https://doi.org/10.3892/or.2019.6958
Copy and paste a formatted citation
x
Spandidos Publications style
Wei CW, Yu YL, Chen YH, Hung YT and Yiang GT: Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer. Oncol Rep 41: 2060-2066, 2019.
APA
Wei, C., Yu, Y., Chen, Y., Hung, Y., & Yiang, G. (2019). Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer. Oncology Reports, 41, 2060-2066. https://doi.org/10.3892/or.2019.6958
MLA
Wei, C., Yu, Y., Chen, Y., Hung, Y., Yiang, G."Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer". Oncology Reports 41.3 (2019): 2060-2066.
Chicago
Wei, C., Yu, Y., Chen, Y., Hung, Y., Yiang, G."Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer". Oncology Reports 41, no. 3 (2019): 2060-2066. https://doi.org/10.3892/or.2019.6958
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