|
1
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng
H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China,
2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Heimbach JK, Kulik LM, Finn RS, Sirlin CB,
Abecassis MM, Roberts LR, Zhu AX, Murad MH and Marrero JA: Aasld
guidelines for the treatment of hepatocellular carcinoma.
Hepatology. 67:358–380. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Choi KJ, Baik IH, Ye SK and Lee YH:
Molecular targeted therapy for hepatocellular carcinoma: Present
status and future directions. Biol Pharm Bull. 38:986–991. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wang Y, Han C, Lu L, Magliato S and Wu T:
Hedgehog signaling pathway regulates autophagy in human
hepatocellular carcinoma cells. Hepatology. 58:995–1010. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Wang Q, Huang S, Yang L, Zhao L, Yin Y,
Liu Z, Chen Z and Zhang H: Down-regulation of Sonic Hedgehog
signaling pathway activity is involved in 5-fluorouracil-induced
apoptosis and motility inhibition in Hep3B cells. Acta Biochim
Biophys Sin. 40:819–829. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Li P, Lee EH, Du F, Gordon RE, Yuelling
LW, Liu Y, Ng JM, Zhang H, Wu J, Korshunov A, et al: Nestin
mediates hedgehog pathway tumorigenesis. Cancer Res. 76:5573–5583.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Hanaoka J, Shimada M, Utsunomiya T, Morine
Y, Imura S, Ikemoto T and Mori H: Significance of sonic Hedgehog
signaling after massive hepatectomy in a rat. Surg Today.
43:300–307. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Lauth M, Bergstrom A, Shimokawa T and
Toftgard R: Inhibition of gli-mediated transcription and tumor cell
growth by small-molecule antagonists. Proc Natl Acad Sci USA.
104:8455–8460. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Axelson M, Liu K, Jiang X, He K, Wang J,
Zhao H, Kufrin D, Palmby T, Dong Z, Russell AM, et al: U.S. Food
and drug administration approval: Vismodegib for recurrent, locally
advanced, or metastatic basal cell carcinoma. Clin Cancer Res.
19:2289–2293. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee SJ, Lindsey S, Graves B, Yoo S, Olson
JM and Langhans SA: Sonic Hedgehog-induced histone deacetylase
activation is required for cerebellar granule precursor hyperplasia
in medulloblastoma. PLoS One. 8:e714552013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Anestopoulos I, Voulgaridou GP,
Georgakilas AG, Franco R, Pappa A and Panayiotidis MI: Epigenetic
therapy as a novel approach in hepatocellular carcinoma. Pharmacol
Ther. 145:103–119. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Hardy T and Mann DA: Epigenetics in liver
disease: From biology to therapeutics. Gut. 65:1895–1905. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Xie HJ, Noh JH, Kim JK, Jung KH, Eun JW,
Bae HJ, Kim MG, Chang YG, Lee JY, Park H, et al: HDAC1 inactivation
induces mitotic defect and caspase-independent autophagic cell
death in liver cancer. PLoS One. 7:e342652012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Noh JH, Jung KH, Kim JK, Eun JW, Bae HJ,
Xie HJ, Chang YG, Kim MG, Park WS, Lee JY, et al: Aberrant
regulation of HDAC2 mediates proliferation of hepatocellular
carcinoma cells by deregulating expression of G1/S cell cycle
proteins. PLoS One. 6:e281032011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wu M, Hernandez M, Shen S, Sabo JK, Kelkar
D, Wang J, O'Leary R, Phillips GR, Cate HS and Casaccia P:
Differential modulation of the oligodendrocyte transcriptome by
sonic hedgehog and bone morphogenetic protein 4 via opposing
effects on histone acetylation. J Neurosci. 32:6651–6664. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Valdora F, Banelli B, Stigliani S, Pfister
SM, Moretti S, Kool M, Remke M, Bai AH, Brigati C, Hielscher T, et
al: Epigenetic silencing of DKK3 in medulloblastoma. Int J
Mol Sci. 14:7492–7505. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Wang D, Li C, Zhang Y, Wang M, Jiang N,
Xiang L, Li T, Roberts TM, Zhao JJ, Cheng H, et al: Combined
inhibition of pi3k and parp is effective in the treatment of
ovarian cancer cells with wild-type PIK3CA genes. Gynecol
Oncol. 142:548–556. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Herynk MH, Stoeltzing O, Reinmuth N,
Parikh NU, Abounader R, Laterra J, Radinsky R, Ellis LM and Gallick
GE: Down-regulation of c-Met inhibits growth in the liver of human
colorectal carcinoma cells. Cancer Res. 63:2990–2996.
2003.PubMed/NCBI
|
|
20
|
Chao H, Wang L, Hao J, Ni J, Chang L,
Graham PH, Kearsley JH and Li Y: Low dose histone deacetylase
inhibitor, LBH589, potentiates anticancer effect of docetaxel in
epithelial ovarian cancer via PI3K/Akt pathway in vitro. Cancer
Lett. 329:17–26. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Song Z, Du Y and Tao Y: Blockade of sonic
Hedgehog signaling decreases viability and induces apoptosis in
retinoblastoma cells: The key role of the pi3k/akt pathway. Oncol
Lett. 14:4099–4105. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Huang S, He J, Zhang X, Bian Y, Yang L,
Xie G, Zhang K, Tang W, Stelter AA, Wang Q, et al: Activation of
the hedgehog pathway in human hepatocellular carcinomas.
Carcinogenesis. 27:1334–1340. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Rudin CM: Vismodegib. Clin Cancer Res.
18:3218–3222. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yauch RL, Dijkgraaf GJ, Alicke B, Januario
T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, et
al: Smoothened mutation confers resistance to a Hedgehog pathway
inhibitor in medulloblastoma. Science. 326:572–574. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Giroux Leprieur E, Vieira T, Antoine M,
Rozensztajn N, Rabbe N, Ruppert AM, Lavole A, Cadranel J and Wislez
M: Sonic Hedgehog pathway activation is associated with resistance
to platinum-based chemotherapy in advanced non-small-cell lung
carcinoma. Clin Lung Cancer. 17:301–308. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Tsai CL, Hsu FM, Tzen KY, Liu WL, Cheng AL
and Cheng JC: Sonic Hedgehog inhibition as a strategy to augment
radiosensitivity of hepatocellular carcinoma. J Gastroenterol
Hepatol. 30:1317–1324. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chun SG, Zhou W and Yee NS: Combined
targeting of histone deacetylases and hedgehog signaling enhances
cytoxicity in pancreatic cancer. Cancer Biol Ther. 8:1328–1339.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Canettieri G, Di Marcotullio L, Greco A,
Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E,
Ferretti E, Miele E, et al: Histone deacetylase and
Cullin3-RENKCTD11 ubiquitin ligase interplay regulates
Hedgehog signalling through Gli acetylation. Nat Cell Biol.
12:132–142. 2010. View
Article : Google Scholar : PubMed/NCBI
|
|
29
|
Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z,
Roskams T, Durnez A, Demetris AJ and Thorgeirsson SS:
Classification and prediction of survival in hepatocellular
carcinoma by gene expression profiling. Hepatology. 40:667–676.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hay JF, Lappin K, Liberante F, Kettyle LM,
Matchett KB, Thompson A and Mills KI: Integrated analysis of the
molecular action of Vorinostat identifies epi-sensitised targets
for combination therapy. Oncotarget. 8:67891–67903. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chen JS, Huang XH, Wang Q, Huang JQ, Zhang
LJ, Chen XL, Lei J and Cheng ZX: Sonic Hedgehog signaling pathway
induces cell migration and invasion through focal adhesion
kinase/AKT signaling-mediated activation of matrix
metalloproteinase (MMP)-2 and MMP-9 in liver cancer.
Carcinogenesis. 34:10–19. 2013. View Article : Google Scholar : PubMed/NCBI
|
