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Article

Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer

  • Authors:
    • Aya Sugyo
    • Winn Aung
    • Atsushi B. Tsuji
    • Hitomi Sudo
    • Hiroki Takashima
    • Masahiro Yasunaga
    • Yasuhiro Matsumura
    • Tsuneo Saga
    • Tatsuya Higashi
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST‑NIRS), Inage, Chiba 263‑8555, Japan, Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277‑8577, Japan, Department of Diagnostic Radiology, Kyoto University Hospital, Sakyo‑ku, Kyoto 606‑8507, Japan
  • Pages: 2371-2378
    |
    Published online on: February 14, 2019
       https://doi.org/10.3892/or.2019.7017
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Abstract

Tissue factor (TF) has emerged as a critical factor in oncogenic events, leading to the development of TF‑targeted diagnostic and therapeutic approaches. A non‑invasive imaging method to evaluate target molecule expression with high sensitivity and high quantitative ability is imperative for selecting the appropriate patients for TF‑targeted therapy. To elucidate the potential of 111In‑labeled anti‑TF antibody 1849 (111In‑1849) as an immuno‑single photon emission computed tomography (SPECT) probe targeting TF, we evaluated TF‑dependent in vitro binding as well as in vivo biodistribution and tumor accumulation of 111In‑1849 in pancreatic cancer cells/models with varying TF expression levels. TF expression levels in five human pancreatic cancer cell lines, BxPC‑3, BxPC‑3‑TF‑knockout (BxPC‑3‑TFKO), Capan‑1, PSN‑1 and SUIT‑2, were examined by immunofluorescence. Binding of 111In‑1849 to each cell line was assessed. Biodistribution and imaging studies were also conducted in tumor‑bearing mice. Furthermore, the relationship of TF expression with cell binding and tumor uptake was analyzed. In the immunofluorescence studies, BxPC‑3 exhibited the highest TF expression, followed by Capan‑1, PSN‑1, SUIT‑2 and BxPC‑3‑TFKO. Cell binding assays revealed that BxPC‑3 cells had the highest 111In‑1849 binding, followed by PSN‑1, Capan‑1 and SUIT‑2; no binding was detected in BxPC‑3‑TFKO cells. The BxPC‑3 xenograft was clearly visualized on 111In‑1849 SPECT/CT, and the highest uptake was detected on day 4. The biodistribution of 111In‑1849 on day 4 revealed that tumor uptake ranged from 8.68 to 50.58% of the injected dose per gram of tissue; BxPC‑3 had the highest uptake and SUIT‑2 had the lowest. TF expression was significantly associated with cell binding (R2=0.79, P<0.05) and tumor uptake (R2=0.92, P<0.01). The association of 111In‑1849 uptake with TF expression suggests the potential application of non‑invasive imaging with radiolabelled 1849 for selecting the appropriate patients who would likely respond to TF‑targeted therapies in clinical practice.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Stein PD, Beemath A, Meyers FA, Skaf E, Sanchez J and Olson RE: Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med. 119:60–68. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Woei-A-Jin FJ, Tesselaar ME, Garcia Rodriguez P, Romijn FP, Bertina RM and Osanto S: Tissue factor-bearing microparticles and CA19.9: Two players in pancreatic cancer-associated thrombosis? Br J Cancer. 115:332–338. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Haas SL, Jesnowski R, Steiner M, Hummel F, Ringel J, Burstein C, Nizze H, Liebe S and Löhr JM: Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation. World J Gastroenterol. 12:4843–4849. 2006.PubMed/NCBI

6 

Steffel J, Luscher TF and Tanner FC: Tissue factor in cardiovascular diseases: Molecular mechanisms and clinical implications. Circulation. 113:722–731. 2006. View Article : Google Scholar : PubMed/NCBI

7 

van den Berg YW, Osanto S, Reitsma PH and Versteeg HH: The relationship between tissue factor and cancer progression: Insights from bench and bedside. Blood. 119:924–932. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Leppert U and Eisenreich A: The role of tissue factor isoforms in cancer biology. Int J Cancer. 137:497–503. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kasthuri RS, Taubman MB and Mackman N: Role of tissue factor in cancer. J Clin Oncol. 27:4834–4838. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Drake TA, Morrissey JH and Edgington TS: Selective cellular expression of tissue factor in human-tissues-implications for disorders of hemostasis and thrombosis. Am J Pathol. 134:1087–1097. 1989.PubMed/NCBI

11 

Vrana JA, Stang MT, Grande JP and Getz MJ: Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: Paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family. Cancer Res. 56:5063–5070. 1996.PubMed/NCBI

12 

Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J and Taubman MB: Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res. 13:2870–2875. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Matsumura Y, Kimura M, Yamamoto T and Maeda H: Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn J Cancer Res. 79:1327–1334. 1988. View Article : Google Scholar : PubMed/NCBI

14 

Fernandez PM, Patierno SR and Rickles FR: Tissue factor and fibrin in tumor angiogenesis. Semin Thromb Hemost. 30:31–44. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Dvorak HF: Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 315:1650–1659. 1986. View Article : Google Scholar : PubMed/NCBI

16 

Hisada Y, Yasunaga M, Hanaoka S, Saijou S, Sugino T, Tsuji A, Saga T, Tsumoto K, Manabe S, Kuroda J, et al: Discovery of an uncovered region in fibrin clots and its clinical significance. Sci Rep. 3:26042013. View Article : Google Scholar : PubMed/NCBI

17 

Saito Y, Hashimoto Y, Kuroda J, Yasunaga M, Koga Y, Takahashi A and Matsumura Y: The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody. Eur J Cancer. 47:2230–2239. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Ueda C, Hirohata Y, Kihara Y, Nakamura H, Abe S, Akahane K, Okamoto K, Itoh H and Otsuki M: Pancreatic cancer complicated by disseminated intravascular coagulation associated with production of tissue factor. J Gastroenterol. 36:848–850. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Kakkar AK, Lemoine NR, Scully MF, Tebbutt S and Williamson RC: Tissue factor expression correlates with histological grade in human pancreatic cancer. Br J Surg. 82:1101–1104. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Callander NS, Varki N and Rao LV: Immunohistochemical identification of tissue factor in solid tumors. Cancer. 70:1194–1201. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Hobbs JE, Zakarija A, Cundiff DL, Doll JA, Hymen E, Cornwell M, Crawford SE, Liu N, Signaevsky M and Soff GA: Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thromb Res. 120 (Suppl 2):S13–S21. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Nitori N, Ino Y, Nakanishi Y, Yamada T, Honda K, Yanagihara K, Kosuge T, Kanai Y, Kitajima M and Hirohashi S: Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res. 11:2531–2539. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Contrino J, Hair G, Kreutzer DL and Rickles FR: In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease. Nat Med. 2:209–215. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Tsumura R, Sato R, Furuya F, Koga Y, Yamamoto Y, Fujiwara Y, Yasunaga M and Matsumura Y: Feasibility study of the Fab fragment of a monoclonal antibody against tissue factor as a diagnostic tool. Int J Oncol. 47:2107–2114. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Koga Y, Manabe S, Aihara Y, Sato R, Tsumura R, Iwafuji H, Furuya F, Fuchigami H, Fujiwara Y, Hisada Y, et al: Antitumor effect of antitissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts. Int J Cancer. 137:1457–1466. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Takashima H, Tsuji AB, Saga T, Yasunaga M, Koga Y, Kuroda JI, Yano S, Kuratsu JI and Matsumura Y: Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model. Sci Rep. 7:123412017. View Article : Google Scholar : PubMed/NCBI

27 

Iwamura T, Katsuki T and Ide K: Establishment and characterization of a human pancreatic cancer cell line (SUIT-2) producing carcinoembryonic antigen and carbohydrate antigen 19-9. Jpn J Cancer Res. 78:54–62. 1987.PubMed/NCBI

28 

Sogawa C, Tsuji AB, Sudo H, Sugyo A, Yoshida C, Odaka K, Uehara T, Arano Y, Koizumi M and Saga T: C-kit-targeted imaging of gastrointestinal stromal tumor using radiolabeled anti-c-kit monoclonal antibody in a mouse tumor model. Nucl Med Biol. 37:179–187. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Sudo H, Tsuji AB, Sugyo A, Ogawa Y, Sagara M and Saga T: ZDHHC8 knockdown enhances radiosensitivity and suppresses tumor growth in a mesothelioma mouse model. Cancer Sci. 103:203–209. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Sugaya A, Hyodo I, Koga Y, Yamamoto Y, Takashima H, Sato R, Tsumura R, Furuya F, Yasunaga M, Harada M, et al: Utility of epirubicin-incorporating micelles tagged with anti-tissue factor antibody clone with no anticoagulant effect. Cancer Sci. 107:335–340. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Yoshida C, Tsuji AB, Sudo H, Sugyo A, Kikuchi T, Koizumi M, Arano Y and Saga T: Therapeutic efficacy of c-kit-targeted radioimmunotherapy using 90Y-labeled anti-c-kit antibodies in a mouse model of small cell lung cancer. PLoS One. 8:e592482013. View Article : Google Scholar : PubMed/NCBI

32 

Sugyo A, Tsuji AB, Sudo H, Nagatsu K, Koizumi M, Ukai Y, Kurosawa G, Zhang MR, Kurosawa Y and Saga T: Evaluation of 89Zr-labeled human anti-CD147 monoclonal antibody as a positron emission tomography probe in a mouse model of pancreatic cancer. PLoS One. 8:e612302013. View Article : Google Scholar : PubMed/NCBI

33 

Matsumura Y and Maeda H: A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46:6387–6392. 1986.PubMed/NCBI

34 

Hong H, Zhang Y, Nayak TR, Engle JW, Wong HC, Liu B, Barnhart TE and Cai W: Immuno-PET of tissue factor in pancreatic cancer. J Nucl Med. 53:1748–1754. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Massoud TF and Gambhir SS: Molecular imaging in living subjects: Seeing fundamental biological processes in a new light. Genes Dev. 17:545–580. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Gnanasegaran G and Ballinger JR: Molecular imaging agents for SPECT (and SPECT/CT). Eur J Nucl Med Mol Imaging. 41 (Suppl 1):S26–S35. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Breij EC, de Goeij BE, Verploegen S, Schuurhuis DH, Amirkhosravi A, Francis J, Miller VB, Houtkamp M, Bleeker WK, Satijn D, et al: An antibody-drug conjugate that targets tissue factor exhibits potent therapeutic activity against a broad range of solid tumors. Cancer Res. 74:1214–1226. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Wang B, Berger M, Masters G, Albone E, Yang Q, Sheedy J, Kirksey Y, Grimm L, Wang B, Singleton J and Soltis D: Radiotherapy of human xenograft NSCLC tumors in nude mice with a 90Y-labeled anti-tissue factor antibody. Cancer Biother Radiopharm. 20:300–309. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Jain M, Gupta S, Kaur S, Ponnusamy MP and Batra SK: Emerging trends for radioimmunotherapy in solid tumors. Cancer Biother Radiopharm. 28:639–650. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Aung W, Tsuji AB, Sugyo A, Takashima H, Yasunaga M, Matsumura Y and Higashi T: Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody. World J Gastroenterol. 24:5491–5504. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sugyo A, Aung W, Tsuji AB, Sudo H, Takashima H, Yasunaga M, Matsumura Y, Saga T and Higashi T: Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncol Rep 41: 2371-2378, 2019.
APA
Sugyo, A., Aung, W., Tsuji, A.B., Sudo, H., Takashima, H., Yasunaga, M. ... Higashi, T. (2019). Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncology Reports, 41, 2371-2378. https://doi.org/10.3892/or.2019.7017
MLA
Sugyo, A., Aung, W., Tsuji, A. B., Sudo, H., Takashima, H., Yasunaga, M., Matsumura, Y., Saga, T., Higashi, T."Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer". Oncology Reports 41.4 (2019): 2371-2378.
Chicago
Sugyo, A., Aung, W., Tsuji, A. B., Sudo, H., Takashima, H., Yasunaga, M., Matsumura, Y., Saga, T., Higashi, T."Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer". Oncology Reports 41, no. 4 (2019): 2371-2378. https://doi.org/10.3892/or.2019.7017
Copy and paste a formatted citation
x
Spandidos Publications style
Sugyo A, Aung W, Tsuji AB, Sudo H, Takashima H, Yasunaga M, Matsumura Y, Saga T and Higashi T: Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncol Rep 41: 2371-2378, 2019.
APA
Sugyo, A., Aung, W., Tsuji, A.B., Sudo, H., Takashima, H., Yasunaga, M. ... Higashi, T. (2019). Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncology Reports, 41, 2371-2378. https://doi.org/10.3892/or.2019.7017
MLA
Sugyo, A., Aung, W., Tsuji, A. B., Sudo, H., Takashima, H., Yasunaga, M., Matsumura, Y., Saga, T., Higashi, T."Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer". Oncology Reports 41.4 (2019): 2371-2378.
Chicago
Sugyo, A., Aung, W., Tsuji, A. B., Sudo, H., Takashima, H., Yasunaga, M., Matsumura, Y., Saga, T., Higashi, T."Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer". Oncology Reports 41, no. 4 (2019): 2371-2378. https://doi.org/10.3892/or.2019.7017
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