MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

  • Authors:
    • Yasu Jiang
    • Yunhui Cai
    • Weiwei Shao
    • Feng Li
    • Zongyu Guan
    • Yi Zhou
    • Chong Tang
    • Shichun Feng
  • View Affiliations

  • Published online on: February 21, 2019     https://doi.org/10.3892/or.2019.7025
  • Pages: 2361-2370
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Abstract

The aim of the present study was to research the mechanism of action of microRNA‑144 (miR‑144) in colorectal cancer (CRC) and its role in tumor progression. It was demonstrated that miR‑144 was downregulated and anoctamin 1 (ANO1) expression was upregulated in CRC. The expression of ANO1 was negatively associated with that of miR‑144 in CRC. The present study indicated that upregulated expression of ANO1 was associated with poor differentiation and advanced tumor‑node‑metastasis stage. It was verified that upregulation of ANO1 expression activated the epidermal growth factor receptor/extracellular signal‑regulated kinase signaling pathway. It was also demonstrated that miR‑144 exerts strong tumor‑inhibiting effects by targeting ANO1. Therefore, miR‑144 may have potential as a prognostic marker or therapeutic target for CRC.
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April-2019
Volume 41 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jiang Y, Cai Y, Shao W, Li F, Guan Z, Zhou Y, Tang C and Feng S: MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncol Rep 41: 2361-2370, 2019
APA
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y. ... Feng, S. (2019). MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncology Reports, 41, 2361-2370. https://doi.org/10.3892/or.2019.7025
MLA
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y., Tang, C., Feng, S."MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer". Oncology Reports 41.4 (2019): 2361-2370.
Chicago
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y., Tang, C., Feng, S."MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer". Oncology Reports 41, no. 4 (2019): 2361-2370. https://doi.org/10.3892/or.2019.7025