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Article

MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

  • Authors:
    • Yasu Jiang
    • Yunhui Cai
    • Weiwei Shao
    • Feng Li
    • Zongyu Guan
    • Yi Zhou
    • Chong Tang
    • Shichun Feng
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of General Surgery, The Fourth Affiliated Hospital of Nantong University, Yancheng, Jiangsu 224006, P.R. China, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 2361-2370
    |
    Published online on: February 21, 2019
       https://doi.org/10.3892/or.2019.7025
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Abstract

The aim of the present study was to research the mechanism of action of microRNA‑144 (miR‑144) in colorectal cancer (CRC) and its role in tumor progression. It was demonstrated that miR‑144 was downregulated and anoctamin 1 (ANO1) expression was upregulated in CRC. The expression of ANO1 was negatively associated with that of miR‑144 in CRC. The present study indicated that upregulated expression of ANO1 was associated with poor differentiation and advanced tumor‑node‑metastasis stage. It was verified that upregulation of ANO1 expression activated the epidermal growth factor receptor/extracellular signal‑regulated kinase signaling pathway. It was also demonstrated that miR‑144 exerts strong tumor‑inhibiting effects by targeting ANO1. Therefore, miR‑144 may have potential as a prognostic marker or therapeutic target for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Cai Y, Shao W, Li F, Guan Z, Zhou Y, Tang C and Feng S: MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncol Rep 41: 2361-2370, 2019.
APA
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y. ... Feng, S. (2019). MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncology Reports, 41, 2361-2370. https://doi.org/10.3892/or.2019.7025
MLA
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y., Tang, C., Feng, S."MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer". Oncology Reports 41.4 (2019): 2361-2370.
Chicago
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y., Tang, C., Feng, S."MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer". Oncology Reports 41, no. 4 (2019): 2361-2370. https://doi.org/10.3892/or.2019.7025
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Cai Y, Shao W, Li F, Guan Z, Zhou Y, Tang C and Feng S: MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncol Rep 41: 2361-2370, 2019.
APA
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y. ... Feng, S. (2019). MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. Oncology Reports, 41, 2361-2370. https://doi.org/10.3892/or.2019.7025
MLA
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y., Tang, C., Feng, S."MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer". Oncology Reports 41.4 (2019): 2361-2370.
Chicago
Jiang, Y., Cai, Y., Shao, W., Li, F., Guan, Z., Zhou, Y., Tang, C., Feng, S."MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer". Oncology Reports 41, no. 4 (2019): 2361-2370. https://doi.org/10.3892/or.2019.7025
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