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Article

Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice

  • Authors:
    • Shinji Mikami
    • Ichiro Ota
    • Takashi Masui
    • Tomoko Uchiyama
    • Hideyuki Okamoto
    • Takahiro Kimura
    • Shin Takasawa
    • Tadashi Kitahara
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Biochemistry, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Otolaryngology, Nara City Hospital, Nara, Nara 630‑8305, Japan
  • Pages: 436-442
    |
    Published online on: April 25, 2019
       https://doi.org/10.3892/or.2019.7137
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Abstract

Identifying the key molecules that enhance chemo‑ and radiosensitivity in head and neck squamous cell carcinoma (HNSCC) as well as reliable biomarkers for predicting recurrence and metastasis would be desirable to improve the prognosis of HNSCC. Previously, we have reported that Regenerating gene III (REG III) expression was associated with an improved survival rate for patients with HNSCC. In addition, resveratrol (3,4',5‑trihydroxystilbene) significantly increased REG III expression in HNSCC cells, and significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked the cancer invasion of HNSCC cells in vitro. In the present study, the effect of resveratrol on cancer progression in HNSCC was investigated in vivo using a xenograft nude mouse model. The results revealed that resveratrol increased the mRNA level of REG III in vivo, which was in agreement with our previous in vitro findings. Furthermore, REG III increased the antitumor effect of radiation or cisplatin in vivo, and resveratrol sensitized HNSCC to irradiation and cisplatin in vivo. These results indicated that resveratrol could increase the efficacy of cisplatin and irradiation through the REG III expression pathway, resulting in the inhibition of HNSCC progression in vivo.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Argiris A, Karamouzis MV, Raben D and Ferris RL: Head and neck cancer. Lancet. 371:1695–1709. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Cooper JS, Zhang Q, Pajak TF, Forastiere AA, Jacobs J, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, et al: Long-term follow-up of the RTOG 9501/intergroup phase III trial: Postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 84:1198–1205. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Adelstein DJ, Saxton JP, Rybicki LA, Esclamado RM, Wood BG, Strome M, Lavertu P, Lorenz RR and Carroll MA: Multiagent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer: Mature results from a single institution. J Clin Oncol. 24:1064–1071. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Fung C and Grandis JR: Emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs. 15:355–373. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Chen YJ, Chang JT, Liao CT, Wang HM, Yen TC, Chiu CC, Lu YC, Li HF and Cheng AJ: Head and neck cancer in the betel quid chewing area: Recent advances in molecular carcinogenesis. Cancer Sci. 99:1507–1514. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y and Okamoto H: A novel gene activated in regenerating islets. J Biol Chem. 263:2111–2114. 1988.PubMed/NCBI

8 

Takasawa S: Regenerating gene (REG) product and its potential clinical usage. Expert Opin Ther Targets. 20:541–550. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Zhao J, Wang J, Wang H and Lai M: Reg proteins and their roles in inflammation and cancer of the human digestive system. Adv Clin Chem. 61:153–173. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H and Okamoto H: Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1217:199–202. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, Vernier P and Brechot C: Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. Eur J Biochem. 224:29–38. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, et al: Molecular cloning, expression and chromosomal localization of a novel human REG family gene. REG III Gene. 340:161–170. 2004.PubMed/NCBI

13 

Hartupee JC, Zhang H, Bonaldo MF, Soares MB and Dieckgraefe BK: Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim Biophys Acta. 1518:287–293. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Watanabe T, Yonemura Y, Yonekura H, Suzuki Y, Miyashita H, Sugiyama K, Moriizumi S, Unno M, Tanaka O, Kondo H, et al: Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc Natl Acad Sci USA. 91:3589–3592. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Asahara M, Mushiake S, Shimada S, Fukui H, Kinoshita Y, Kawanami C, Watanabe T, Tanaka S, Ichikawa A, Uchiyama Y, et al: Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress. Gastroenterology. 111:45–55. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Macadam RC, Sarela AI, Farmery SM, Robinson PA, Markham AF and Guillou PJ: Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. Br J Cancer. 83:188–195. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Harada K, Zen Y, Kanemori Y, Chen TC, Chen MF, Yeh TS, Jan YY, Masuda S, Nimura Y, Takasawa S, et al: Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions. Hepatology. 33:1036–1042. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M and Lesuffleur T: REG IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int J Cancer. 103:185–193. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Yonemura Y, Sakurai S, Yamamoto H, Endou Y, Kawamura T, Bandou E, Elnemr A, Sugiyama K, Sasaki T, Akiyama T, et al: REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer. 98:1394–1400. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Dhar DK, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, Okamoto H, Kubota H, Fujii T, Tachibana M and Nagasue N: Expression of regenerating gene I in gastric adenocarcinomas: Correlation with tumor differentiation status and patient survival. Cancer. 100:1130–1136. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Bishnupuri KS, Luo Q, Murmu N, Houchen CW, Anant S and Dieckgraefe BK: REG IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology. 130:137–149. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Hayashi K, Motoyama S, Koyota S, Koizumi Y, Wang J, Takasawa S, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Maruyama K, Saito H, et al: REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells. Cancer Sci. 99:2491–2495. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Hayashi T, Matsubara A, Ohara S, Mita K, Hasegawa Y, Usui T, Arihiro K, Norimura S, Sentani K, Oue N and Yasui W: Immunohistochemical analysis of REG IV in urogenital organs: Frequent expression of REG IV in prostate cancer and potential utility as serum tumor marker. Oncol Rep. 21:95–100. 2009.PubMed/NCBI

24 

Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, et al: Upregulation of REG I alpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer. 127:1795–1803. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Kimura M, Naito H, Tojo T, Itaya-Hironaka A, Dohi Y, Yoshimura M, Nakagawara K, Takasawa S and Taniguchi S: REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms. Oncol Rep. 30:2625–2631. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Masui T, Ota I, Itaya-Hironaka A, Takeda M, Kasai T, Yamauchi A, Sakuramoto-Tsuchida S, Mikami S, Yane K, Takasawa S and Hosoi H: Expression of REG III and prognosis in head and neck cancer. Oncol Rep. 30:573–578. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Mikami S, Ota I, Masui T, Itaya-Hironaka A, Shobatake R, Okamoto H, Takasawa S and Kitahara T: Effect of resveratrol on cancer progression through the REG III expression pathway in head and neck cancer cells. Int J Oncol. 49:1553–1560. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Ota H, Tamaki S, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Morioka T, Takasawa S and Kimura H: Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38. Life Sci. 90:206–211. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Nakagawa K, Takasawa S, Nata K, Yamauchi A, Itaya-Hironaka A, Ota H, Yoshimoto K, Sakuramoto-Tsuchida S, Miyaoka T, Takeda M, et al: Prevention of REG I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation. Biochim Biophys Acta. 1833:2988–2995. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Yamauchi A, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takeda M, Yoshimoto K, Miyaoka T, Fujimura T, Tsujinaka H, Tsuchida C, Ota H and Takasawa S: Synergistic activations of REG Iα and REG Iβ promoters by IL-6 and glucocorticoids through JAK/STAT pathway in human pancreatic β cells. J Diabetes Res. 2015:1730582015. View Article : Google Scholar : PubMed/NCBI

31 

Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Yamauchi A, Sakuramoto-Tsuchida S, Kondo S, Takeda M, Tsujinaka H, et al: Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjögren's syndrome patients, in salivary duct epithelial cells. Biochem Biophys Rep. 2:69–74. 2015.PubMed/NCBI

32 

Tsujinaka H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Ota H, Takeda M, Fujimura T, Takasawa S and Ogata N: Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene. Biochem Biophys Rep. 2:123–131. 2015.PubMed/NCBI

33 

Takasawa S, Kuroki M, Nata K, Noguchi N, Ikeda T, Yamauchi A, Ota H, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takahashi I, et al: A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene. Biochem Biophys Res Commun. 397:140–145. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Renaud S and de Lorgeril M: Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 20:1523–1526. 1992. View Article : Google Scholar

35 

Frémont L: Biological effects of resveratrol. Life Sci. 66:663–673. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Cal C, Garban H, Jazirehi A, Yeh C, Mizutani Y and Bonavida B: Resveratrol and cancer: Chemoprevention, apoptosis, and chemo-immunosensitizing activities. Curr Med Chem Anticancer Agents. 3:77–93. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Kundu JK and Surh YJ: Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives. Cancer Lett. 269:243–261. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG and Pezzuto JM: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 10:218–220. 1997. View Article : Google Scholar

39 

Bai Y, Mao QQ, Qin J, Zheng XY, Wang YB, Yang K, Shen HF and Xie LP: Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 101:488–493. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Yang S, Li W, Sun H, Wu B, Ji F, Sun T, Chang H, Shen P, Wang Y and Zhou D: Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo. BMC Cancer. 15:9692015. View Article : Google Scholar : PubMed/NCBI

41 

Tan L, Wang W, He G, Kuick RD, Gossner G, Kueck AS, Wahl H, Opipari AW and Liu JR: Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 122:722–729. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Tan Y, Wei X, Zhang W, Wang X, Wang K, Du B and Xiao J: Resveratrol enhances the radiosensitivity of nasopharyngeal carcinoma cells by downregulating E2F1. Oncol Rep. 37:1833–1841. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Yin HT, Tian QZ, Guan L, Zhou Y, Huang XE and Zhang H: In vitro and in vivo evaluation of the antitumor efficiency of resveratrol against lung cancer. Asian Pac J Cancer Prev. 14:1703–1706. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M and Aggarwal BB: Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood. 102:987–995. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Liang YC, Tsai SH, Chen L, Lin-Shiau SY and Lin JK: Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Biochem Pharmacol. 65:1053–1060. 2003. View Article : Google Scholar : PubMed/NCBI

46 

ElAttar TM and Virji AS: Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs. 10:187–193. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Yeh CB, Hsieh MJ, Lin CW, Chiou HL, Lin PY, Chen TY and Yang SF: The antimetastatic effects of resveratrol on hepatocellular carcinoma through the downregulation of a metastasis-associated protease by SP-1 modulation. PLoS One. 8:e566612013. View Article : Google Scholar : PubMed/NCBI

48 

Shankar S, Singh G and Srivastava RK: Chemoprevention by resveratrol: Molecular mechanisms and therapeutic potential. Front Biosci. 12:4839–4854. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Liu B, Zhou Z, Zhou W, Liu J, Zhang Q, Xia J, Liu J, Chen N, Li M and Zhu R: Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S phase cell cycle arrest and apoptosis through caspase/cyclin CDK pathways. Mol Med Rep. 10:1697–1702. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Wang G, Guo X, Chen H, Lin T, Xu Y, Chen Q, Liu J, Zeng J, Zhang XK and Yao X: A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Bioorg Med Chem Lett. 22:2114–2118. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mikami S, Ota I, Masui T, Uchiyama T, Okamoto H, Kimura T, Takasawa S and Kitahara T: Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice. Oncol Rep 42: 436-442, 2019.
APA
Mikami, S., Ota, I., Masui, T., Uchiyama, T., Okamoto, H., Kimura, T. ... Kitahara, T. (2019). Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice. Oncology Reports, 42, 436-442. https://doi.org/10.3892/or.2019.7137
MLA
Mikami, S., Ota, I., Masui, T., Uchiyama, T., Okamoto, H., Kimura, T., Takasawa, S., Kitahara, T."Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice". Oncology Reports 42.1 (2019): 436-442.
Chicago
Mikami, S., Ota, I., Masui, T., Uchiyama, T., Okamoto, H., Kimura, T., Takasawa, S., Kitahara, T."Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice". Oncology Reports 42, no. 1 (2019): 436-442. https://doi.org/10.3892/or.2019.7137
Copy and paste a formatted citation
x
Spandidos Publications style
Mikami S, Ota I, Masui T, Uchiyama T, Okamoto H, Kimura T, Takasawa S and Kitahara T: Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice. Oncol Rep 42: 436-442, 2019.
APA
Mikami, S., Ota, I., Masui, T., Uchiyama, T., Okamoto, H., Kimura, T. ... Kitahara, T. (2019). Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice. Oncology Reports, 42, 436-442. https://doi.org/10.3892/or.2019.7137
MLA
Mikami, S., Ota, I., Masui, T., Uchiyama, T., Okamoto, H., Kimura, T., Takasawa, S., Kitahara, T."Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice". Oncology Reports 42.1 (2019): 436-442.
Chicago
Mikami, S., Ota, I., Masui, T., Uchiyama, T., Okamoto, H., Kimura, T., Takasawa, S., Kitahara, T."Resveratrol‑induced REG III expression enhances chemo‑ and radiosensitivity in head and neck cancer in xenograft mice". Oncology Reports 42, no. 1 (2019): 436-442. https://doi.org/10.3892/or.2019.7137
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