Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues

Pan,Hailing; Zheng,Yue; Pan,Qi; Chen,Honglei; Chen,Fuchun; Wu,Jie; Di,Dingxin

doi:10.3892/or.2019.7279

Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues

Authors:
- Hailing Pan
- Yue Zheng
- Qi Pan
- Honglei Chen
- Fuchun Chen
- Jie Wu
- Dingxin Di
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Affiliations: Department of Medical Oncology, Taizhou Integrated Chinese and Western Medicine Hospital, Zhejiang University of Traditional Chinese Medicine, Wenling, Zhejiang 317500, P.R. China, Department of Radiology, Traditional Chinese Medical Hospital of Wenling, Wenling, Zhejiang 317500, P.R. China, Department of Thoracosurgery, Traditional Chinese Medical Hospital of Wenling, Wenling, Zhejiang 317500, P.R. China, Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, Hubei 430071, P.R. China
Published online on: August 14, 2019 https://doi.org/10.3892/or.2019.7279
Pages: 1869-1877
Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have reported that liver X receptor (LXR), ATP‑binding cassette sub‑family G number 1 (ABCG1) and ATP‑binding cassette transporter number 1 (ABCA1), which are associated with cholesterol metabolism, may be associated with the development and progression of breast cancer. The expression levels of LXR‑β, ABCA1 and ABCG1 in triple‑negative breast cancer (TNBC) tissues and in non‑cancerous mammary tissues were observed by immunohistochemistry, quantum dot‑based immunohistochemistry, western blot analysis and reverse transcription‑quantitative polymerase chain reaction. The present study identified that the expression of ABCA1 in TNBC tissues was higher than that in non‑cancerous mammary tissues. A high expression of ABCA1 in the TNBC tissues was significantly associated with the histological grade. However, no significant differences were identified between the expression levels of LXR‑β and ABCG1 in the TNBC tissues compared with the non‑cancerous mammary tissues. Therefore, the findings of this study suggest that ABCA1 is a specific marker for TNBC.

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