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miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A

  • Authors:
    • Wei Zhang
    • Jing Xu
    • Ke Wang
    • Xiaojiang Tang
    • Jianjun He
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1699-1708
    |
    Published online on: August 29, 2019
       https://doi.org/10.3892/or.2019.7297
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Abstract

Accumulated evidence indicates that aberrant microRNAs (miRNAs) expression plays an important role in the initiation and progression of various cancers, including breast cancer. Previous studies suggested that miR‑139‑3p might serve as a tumor suppressor and is downregulated in several cancer types. However, the expression patterns and exact role of miR‑139‑3p in breast cancer remain to be elucidated. In this study, we aimed to analyze the effect of miR‑139‑3p on the progression of breast cancer and the mechanism involved. Through bioinformatics analysis and in vitro experimental studies, we found that miR‑139‑3p was decreased in breast cancer tissues and cell lines, and decreased miR‑139‑3p is associated with a poor prognosis in breast cancer patients. Overexpression of miR‑139‑3p by transfection significantly inhibits cell proliferation, migration, and invasion of breast cancer cells. Bioinformatics analysis and luciferase reporter gene assay confirmed that RAB1A was a potential target of miR‑139‑3p. Furthermore, overexpression of RAB1A counteracted the suppressing effects of miR‑139‑3p on breast cancer cell migration, invasion and epithelial‑to‑mesenchymal transition (EMT). Taken together, these data suggest that miR‑139‑3p plays a tumor suppressive role in breast cancer by targeting RAB1A and may serve as a potential new biomarker for breast cancer prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Xu J, Wang K, Tang X and He J: miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A. Oncol Rep 42: 1699-1708, 2019.
APA
Zhang, W., Xu, J., Wang, K., Tang, X., & He, J. (2019). miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A. Oncology Reports, 42, 1699-1708. https://doi.org/10.3892/or.2019.7297
MLA
Zhang, W., Xu, J., Wang, K., Tang, X., He, J."miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A". Oncology Reports 42.5 (2019): 1699-1708.
Chicago
Zhang, W., Xu, J., Wang, K., Tang, X., He, J."miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A". Oncology Reports 42, no. 5 (2019): 1699-1708. https://doi.org/10.3892/or.2019.7297
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Xu J, Wang K, Tang X and He J: miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A. Oncol Rep 42: 1699-1708, 2019.
APA
Zhang, W., Xu, J., Wang, K., Tang, X., & He, J. (2019). miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A. Oncology Reports, 42, 1699-1708. https://doi.org/10.3892/or.2019.7297
MLA
Zhang, W., Xu, J., Wang, K., Tang, X., He, J."miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A". Oncology Reports 42.5 (2019): 1699-1708.
Chicago
Zhang, W., Xu, J., Wang, K., Tang, X., He, J."miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A". Oncology Reports 42, no. 5 (2019): 1699-1708. https://doi.org/10.3892/or.2019.7297
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