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Article

DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma

  • Authors:
    • Mehrdad Mazdak
    • Hossein Tezval
    • Janne Carmen Callauch
    • Natalia Dubrowinskaja
    • Inga Peters
    • Carsten Bokemeyer
    • Jörg Hennenlotter
    • Arnulf Stenzl
    • Markus A. Kuczyk
    • Jürgen Serth
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Hannover Medical School (MHH), D‑30625 Hannover, Germany, Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany, Department of Urology, Eberhard‑Karls University, D‑72076 Tübingen, Germany
  • Pages: 2159-2168
    |
    Published online on: September 9, 2019
       https://doi.org/10.3892/or.2019.7305
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Abstract

DNA methylation plays an important role in the genesis and progression of tumor diseases. To identify new DNA methylation markers possibly associated with the clinical characteristics of renal cell carcinoma (RCC), we investigated loci in the sarcosine dehydrogenase (SARDH) gene. SARDH is involved in the metabolism of the glycine‑derivative sarcosine and is closely linked through a functional control loop. Statistical evaluation of methylation data and clinical characteristics of patients showed that kidney tumors with clinically aggressive features such as a high tumor stage, positive lymph nodes, distant metastases or a previously advanced tumor status exhibited significantly lower methylation of a locus in the SARDH gene. Moreover, SARDH methylation was found to be a significant prognostic factor for recurrence‑free survival in RCC patients showing statistical independence from the clinical prognosticators, grade, stage and state of metastasis. In conclusion, the methylation status of the SARDH‑CGI was identified as an independent prognostic candidate marker for RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Mazdak M, Tezval H, Callauch JC, Dubrowinskaja N, Peters I, Bokemeyer C, Hennenlotter J, Stenzl A, Kuczyk MA, Serth J, Serth J, et al: DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma. Oncol Rep 42: 2159-2168, 2019.
APA
Mazdak, M., Tezval, H., Callauch, J.C., Dubrowinskaja, N., Peters, I., Bokemeyer, C. ... Serth, J. (2019). DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma. Oncology Reports, 42, 2159-2168. https://doi.org/10.3892/or.2019.7305
MLA
Mazdak, M., Tezval, H., Callauch, J. C., Dubrowinskaja, N., Peters, I., Bokemeyer, C., Hennenlotter, J., Stenzl, A., Kuczyk, M. A., Serth, J."DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma". Oncology Reports 42.5 (2019): 2159-2168.
Chicago
Mazdak, M., Tezval, H., Callauch, J. C., Dubrowinskaja, N., Peters, I., Bokemeyer, C., Hennenlotter, J., Stenzl, A., Kuczyk, M. A., Serth, J."DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma". Oncology Reports 42, no. 5 (2019): 2159-2168. https://doi.org/10.3892/or.2019.7305
Copy and paste a formatted citation
x
Spandidos Publications style
Mazdak M, Tezval H, Callauch JC, Dubrowinskaja N, Peters I, Bokemeyer C, Hennenlotter J, Stenzl A, Kuczyk MA, Serth J, Serth J, et al: DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma. Oncol Rep 42: 2159-2168, 2019.
APA
Mazdak, M., Tezval, H., Callauch, J.C., Dubrowinskaja, N., Peters, I., Bokemeyer, C. ... Serth, J. (2019). DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma. Oncology Reports, 42, 2159-2168. https://doi.org/10.3892/or.2019.7305
MLA
Mazdak, M., Tezval, H., Callauch, J. C., Dubrowinskaja, N., Peters, I., Bokemeyer, C., Hennenlotter, J., Stenzl, A., Kuczyk, M. A., Serth, J."DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma". Oncology Reports 42.5 (2019): 2159-2168.
Chicago
Mazdak, M., Tezval, H., Callauch, J. C., Dubrowinskaja, N., Peters, I., Bokemeyer, C., Hennenlotter, J., Stenzl, A., Kuczyk, M. A., Serth, J."DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma". Oncology Reports 42, no. 5 (2019): 2159-2168. https://doi.org/10.3892/or.2019.7305
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