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Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma

  • Authors:
    • Hanyu Li
    • Junyu Long
    • Fucun Xie
    • Kai Kang
    • Yue Shi
    • Weiyu Xu
    • Xiaoqian Wu
    • Jianzhen Lin
    • Haifeng Xu
    • Shunda Du
    • Yiyao Xu
    • Haitao Zhao
    • Yongchang Zheng
    • Jin Gu
  • View Affiliations / Copyright

    Affiliations: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, MOE Key Laboratory of Bioinformatics, BNIRST Bioinformatics Division, Department of Automation, Tsinghua University, Beijing 100084, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1833-1842
    |
    Published online on: September 17, 2019
       https://doi.org/10.3892/or.2019.7318
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Abstract

Cholangiocarcinoma (CCA) is acknowledged as the second most commonly diagnosed primary liver tumor and is associated with a poor patient prognosis. The present study aimed to explore the biological functions, signaling pathways and potential prognostic biomarkers involved in CCA through transcriptomic analysis. Based on the transcriptomic dataset of CCA from The Cancer Genome Atlas (TCGA), differentially expressed protein‑coding genes (DEGs) were identified. Biological function enrichment analysis, including Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, was applied. Through protein‑protein interaction (PPI) network analysis, hub genes were identified and further verified using open‑access datasets and qRT‑PCR. Finally, a survival analysis was conducted. A total of 1,463 DEGs were distinguished, including 267 upregulated genes and 1,196 downregulated genes. For the GO analysis, the upregulated DEGs were enriched in ‘cadherin binding in cell‑cell adhesion’, ‘extracellular matrix (ECM) organization’ and ‘cell‑cell adherens junctions’. Correspondingly, the downregulated DEGs were enriched in the ‘oxidation‑reduction process’, ‘extracellular exosomes’ and ‘blood microparticles’. In regards to the KEGG pathway analysis, the upregulated DEGs were enriched in ‘ECM‑receptor interactions’, ‘focal adhesions’ and ‘small cell lung cancer’. The downregulated DEGs were enriched in ‘metabolic pathways’, ‘complement and coagulation cascades’ and ‘biosynthesis of antibiotics’. The PPI network suggested that CDK1 and another 20 genes were hub genes. Furthermore, survival analysis suggested that CDK1, MKI67, TOP2A and PRC1 were significantly associated with patient prognosis. These results enhance the current understanding of CCA development and provide new insight into distinguishing candidate biomarkers for predicting the prognosis of CCA.
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View References

1 

Razumilava N and Gores GJ: Cholangiocarcinoma. Lancet. 383:2168–2179. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Zhang H, Shen F, Han J, Shen YN, Xie GQ, Wu MC and Yang T: Epidemiology and surgical management of intrahepatic cholangiocarcinoma. Hepat Oncol. 3:83–91. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Bergquist A and von Seth E: Epidemiology of cholangiocarcinoma. Best Pract Res Clin Gastroenterol. 29:221–232. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Hu J and Yin B: Advances in biomarkers of biliary tract cancers. Biomed Pharmacother. 81:128–135. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Esnaola NF, Meyer JE, Karachristos A, Maranki JL, Camp ER and Denlinger CS: Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma. Cancer. 122:1349–1369. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Squadroni M, Tondulli L, Gatta G, Mosconi S, Beretta G and Labianca R: Cholangiocarcinoma. Crit Rev Oncol Hematol. 116:11–31. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Zhu AX: Future directions in the treatment of cholangiocarcinoma. Best Pract Res Clin Gastroenterol. 29:355–361. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Rizvi S and Gores GJ: Emerging molecular therapeutic targets for cholangiocarcinoma. J Hepatol. 67:632–644. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Mertens JC, Rizvi S and Gores GJ: Targeting cholangiocarcinoma. Biochim Biophys Acta Mol Basis Dis. 1864:1454–1460. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Ghouri YA, Mian I and Blechacz B: Cancer review: Cholangiocarcinoma. J Carcinog. 14:12015. View Article : Google Scholar : PubMed/NCBI

11 

Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, et al: Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma. Cancer Discov. 7:1116–1135. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Tomczak K, Czerwińska P and Wiznerowicz M: The cancer genome atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

13 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43((Database Issue)): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zheng Y, Long J, Wu L, Zhang H, Li L, Zheng Y, Wang A, Lin J, Yang X, Sang X, et al: Identification of hub genes involved in the development of hepatocellular carcinoma by transcriptome sequencing. Oncotarget. 8:60358–60367. 2017.PubMed/NCBI

15 

Wang X, Hu KB, Zhang YQ, Yang CJ and Yao HH: Comprehensive analysis of aberrantly expressed profiles of lncRNAs, miRNAs and mRNAs with associated ceRNA network in cholangiocarcinoma. Cancer Biomarkers. 23:549–559. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Anders S and Huber W: Differential expression analysis for sequence count data. Genome Biol. 11:R1062010. View Article : Google Scholar : PubMed/NCBI

17 

Team RDC: R: A language and environment for statistical computing. Journal. 2010.

18 

Walter W, Sánchez-Cabo F and Ricote M: GOplot: An R package for visually combining expression data with functional analysis. Bioinformatics. 31:2912–2914. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Choi JK, Yu U, Yoo OJ and Kim S: Differential coexpression analysis using microarray data and its application to human cancer. Bioinformatics. 21:4348–4355. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, et al: Common molecular subtypes among asian hepatocellular carcinoma and cholangiocarcinoma. Cancer Cell. 32:57–70.e53. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Andersen JB, Spee B, Blechacz BR, Avital I, Komuta M, Barbour A, Conner EA, Gillen MC, Roskams T, Roberts LR, et al: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology. 142:1021–1031.e15. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, et al: Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatology. 56:1792–1803. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Sulpice L, Rayar M, Desille M, Turlin B, Fautrel A, Boucher E, Llamas-Gutierrez F, Meunier B, Boudjema K, Clément B and Coulouarn C: Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma. Hepatology. 58:1992–2000. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Sulpice L, Desille M, Turlin B, Fautrel A, Boudjema K, Clément B and Coulouarn C: Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma. Genom Data. 7:229–232. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

26 

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC and Müller M: pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 12:772011. View Article : Google Scholar : PubMed/NCBI

27 

Therneau TM: A package for survival analysis in S. version 2.38. 2015, https://CRAN.R-project.org/package=survival

28 

Terry M and Therneau PMG: Modeling Survival data: Extending the Cox ModelDietz K, Gail M, Krickeberg K, Samet J and Tsiatis A: Springer; New York, NY: 2000

29 

Holt LJ, Tuch BB, Villen J, Johnson AD, Gygi SP and Morgan DO: Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 325:1682–1686. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Ravindran Menon D, Luo Y, Arcaroli JJ, Liu S, KrishnanKutty LN, Osborne DG, Li Y, Samson JM, Bagby S, Tan AC, et al: CDK1 Interacts with Sox2 and promotes tumor initiation in human melanoma. Cancer Res. 78:6561–6574. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Okumura E, Fukuhara T, Yoshida H, Hanada Si S, Kozutsumi R, Mori M, Tachibana K and Kishimoto T: Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. Nat Cell Biol. 4:111–116. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Wattanawongdon W, Hahnvajanawong C, Namwat N, Kanchanawat S, Boonmars T, Jearanaikoon P, Leelayuwat C, Techasen A and Seubwai W: Establishment and characterization of gemcitabine-resistant human cholangiocarcinoma cell lines with multidrug resistance and enhanced invasiveness. Int J Oncol. 47:398–410. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Booth DG, Takagi M, Sanchez-Pulido L, Petfalski E, Vargiu G, Samejima K, Imamoto N, Ponting CP, Tollervey D, Earnshaw WC and Vagnarelli P: Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. Elife. 3:e016412014. View Article : Google Scholar : PubMed/NCBI

34 

Klöppel G and La Rosa S: Ki67 labeling index: Assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms. Virchows Arch. 472:341–349. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Miller HC, Drymousis P, Flora R, Goldin R, Spalding D and Frilling A: Role of Ki-67 proliferation index in the assessment of patients with neuroendocrine neoplasias regarding the stage of disease. World J Surg. 38:1353–1361. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Singh S, Hallet J, Rowsell C and Law CHL: Variability of Ki67 labeling index in multiple neuroendocrine tumors specimens over the course of the disease. Eur J Surg Oncol. 40:1517–1522. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Grillo F, Albertelli M, Brisigotti MP, Borra T, Boschetti M, Fiocca R, Ferone D and Mastracci L: Grade increases in gastroenteropancreatic neuroendocrine tumor metastases compared to the primary tumor. Neuroendocrinology. 103:452–459. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Romero A, Martín M, Cheang MC, López García-Asenjo JA, Oliva B, He X, de la Hoya M, García Sáenz JÁ, Arroyo Fernández M, Díaz Rubio E, et al: Assessment of Topoisomerase II α status in breast cancer by quantitative PCR, gene expression microarrays, immunohistochemistry, and fluorescence in situ hybridization. Am J Pathol. 178:1453–1460. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Järvinen TA and Liu LE: Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes-molecular basis for combination chemotherapy in cancer. Curr Cancer Drug Targets. 6:579–602. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Liang Z, Zeng X, Gao J, Wu S, Wang P, Shi X, Zhang J and Liu T: Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients. BMC Cancer. 8:3632008. View Article : Google Scholar : PubMed/NCBI

41 

Press MF, Sauter G, Buyse M, Bernstein L, Guzman R, Santiago A, Villalobos IE, Eiermann W, Pienkowski T, Martin M, et al: Alteration of topoisomerase II-alpha gene in human breast cancer: Association with responsiveness to anthracycline-based chemotherapy. J Clin Oncol. 29:859–867. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Simon R, Atefy R, Wagner U, Forster T, Fijan A, Bruderer J, Wilber K, Mihatsch MJ, Gasser T and Sauter G: HER-2 and TOP2A coamplification in urinary bladder cancer. Int J Cancer. 107:764–772. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Panvichian R, Tantiwetrueangdet A, Angkathunyakul N and Leelaudomlipi S: TOP2A amplification and overexpression in hepatocellular carcinoma tissues. Biomed Res Int. 2015:3816022015. View Article : Google Scholar : PubMed/NCBI

44 

Nateewattana J, Dutta S, Reabroi S, Saeeng R, Kasemsook S, Chairoungdua A, Weerachayaphorn J, Wongkham S and Piyachaturawat P: Induction of apoptosis in cholangiocarcinoma by an andrographolide analogue is mediated through topoisomerase II alpha inhibition. Eur J Pharmacol. 723:148–155. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Gil J and O'Loghlen A: PRC1 complex diversity: Where is it taking us? Trends Cell Biol. 24:632–641. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Tang H, Xiao G, Behrens C, Schiller J, Allen J, Chow CW, Suraokar M, Corvalan A, Mao J, White MA, et al: A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin Cancer Res. 19:1577–1586. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Sasaki M, Yamaguchi J, Ikeda H, Itatsu K and Nakanuma Y: Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: Tissue and culture studies. Hum Pathol. 40:1723–1730. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Sasaki M, Yamaguchi J, Itatsu K, Ikeda H and Nakanuma Y: Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis. J Pathol. 215:175–183. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Hu CK, Coughlin M and Mitchison TJ: Midbody assembly and its regulation during cytokinesis. Mol Biol Cell. 23:1024–1034. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Sadler JBA, Wenzel DM, Williams LK, Guindo-Martínez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI and Martin-Serrano J: A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc Natl Acad Sci USA. 115:E8900–E8908. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Fu Y, Huang J, Wang KS, Zhang X and Han ZG: RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells. Mol Biol Rep. 38:693–702. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW and Trimble WS: Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. J Biol Chem. 288:30075–30086. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Long J, Xie F, Kang K, Shi Y, Xu W, Wu X, Lin J, Xu H, Du S, Du S, et al: Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma. Oncol Rep 42: 1833-1842, 2019.
APA
Li, H., Long, J., Xie, F., Kang, K., Shi, Y., Xu, W. ... Gu, J. (2019). Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma. Oncology Reports, 42, 1833-1842. https://doi.org/10.3892/or.2019.7318
MLA
Li, H., Long, J., Xie, F., Kang, K., Shi, Y., Xu, W., Wu, X., Lin, J., Xu, H., Du, S., Xu, Y., Zhao, H., Zheng, Y., Gu, J."Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma". Oncology Reports 42.5 (2019): 1833-1842.
Chicago
Li, H., Long, J., Xie, F., Kang, K., Shi, Y., Xu, W., Wu, X., Lin, J., Xu, H., Du, S., Xu, Y., Zhao, H., Zheng, Y., Gu, J."Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma". Oncology Reports 42, no. 5 (2019): 1833-1842. https://doi.org/10.3892/or.2019.7318
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Long J, Xie F, Kang K, Shi Y, Xu W, Wu X, Lin J, Xu H, Du S, Du S, et al: Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma. Oncol Rep 42: 1833-1842, 2019.
APA
Li, H., Long, J., Xie, F., Kang, K., Shi, Y., Xu, W. ... Gu, J. (2019). Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma. Oncology Reports, 42, 1833-1842. https://doi.org/10.3892/or.2019.7318
MLA
Li, H., Long, J., Xie, F., Kang, K., Shi, Y., Xu, W., Wu, X., Lin, J., Xu, H., Du, S., Xu, Y., Zhao, H., Zheng, Y., Gu, J."Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma". Oncology Reports 42.5 (2019): 1833-1842.
Chicago
Li, H., Long, J., Xie, F., Kang, K., Shi, Y., Xu, W., Wu, X., Lin, J., Xu, H., Du, S., Xu, Y., Zhao, H., Zheng, Y., Gu, J."Transcriptomic analysis and identification of prognostic biomarkers in cholangiocarcinoma". Oncology Reports 42, no. 5 (2019): 1833-1842. https://doi.org/10.3892/or.2019.7318
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