Open Access

Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma

  • Authors:
    • Shu Li
    • Zhou Jiang
    • Yirun Li
    • Yang Xu
  • View Affiliations

  • Published online on: September 23, 2019     https://doi.org/10.3892/or.2019.7330
  • Pages: 2279-2292
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic value and functions of MCMs in LUAD were investigated using several databases and bioinformatic tools, including Oncomine, GEPIA, cBioPortal, CancerSEA and Kaplan‑Meier plotter. It was demonstrated that the mRNA expression of MCM2, MCM4 and MCM10 were significantly increased in patients with LUAD. High mRNA expression of MCM2‑5, MCM8 and MCM10 were associated with poor overall survival and progression‑free survival. High MCM4 expression was associated with adverse post‑progression survival. In addition, the Human Protein Atlas database showed that MCM protein expression was consistent with the mRNA expression. These results demonstrate that MCM2, MCM4 and MCM10 are potential prognostic markers and therapeutic targets for LUAD.
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December-2019
Volume 42 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li S, Jiang Z, Li Y and Xu Y: Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma. Oncol Rep 42: 2279-2292, 2019
APA
Li, S., Jiang, Z., Li, Y., & Xu, Y. (2019). Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma. Oncology Reports, 42, 2279-2292. https://doi.org/10.3892/or.2019.7330
MLA
Li, S., Jiang, Z., Li, Y., Xu, Y."Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma". Oncology Reports 42.6 (2019): 2279-2292.
Chicago
Li, S., Jiang, Z., Li, Y., Xu, Y."Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma". Oncology Reports 42, no. 6 (2019): 2279-2292. https://doi.org/10.3892/or.2019.7330