Cytotoxicity of Cichorium intybus L. metabolites (Review)

  • Authors:
    • Khandaker Md Sharif Uddin Imam
    • Yingying Xie
    • Yusi Liu
    • Fengzhong Wang
    • Fengjiao Xin
  • View Affiliations

  • Published online on: September 24, 2019     https://doi.org/10.3892/or.2019.7336
  • Pages: 2196-2212
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Abstract

Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial, herbaceous member of the Asteraceae family. Besides its use in modern Chinese herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece, Egypt and China. It is also used as a food and coffee substitute, which is mainly responsible for its extensive domestication. In recent decades, cytotoxic studies of C. intybus extracts have shown its antitumor potential. These studies also identified metabolite constituents including guaianolides, 6‑methoxyflavone, eudesmanolides, germacranolides, polyacetylene, sterol, anthocyanin, delphinidin, 3,4‑dihydroxyphenethyl and other novel compounds. Many of these phytometabolites have shown positive cytotoxic activities in vitro, and antitumor action in vivo and in clinical trials, demonstrating the potential of C. intybus metabolites as antitumor drugs. Structural activity relationship studies have further confirmed these bioactivities. In this review, we focused on the phytochemicals of C. intybus with reported cytotoxicity and potential antitumor properties. We also discuss their specificity towards tumor cells, structural activity relationship, the involved signaling pathways and molecular mechanism, with the expectation of the future development of efficient and targeted antitumor therapeutic strategies.
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December-2019
Volume 42 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Imam KM, Xie Y, Liu Y, Wang F and Xin F: Cytotoxicity of Cichorium intybus L. metabolites (Review). Oncol Rep 42: 2196-2212, 2019
APA
Imam, K.M., Xie, Y., Liu, Y., Wang, F., & Xin, F. (2019). Cytotoxicity of Cichorium intybus L. metabolites (Review). Oncology Reports, 42, 2196-2212. https://doi.org/10.3892/or.2019.7336
MLA
Imam, K. M., Xie, Y., Liu, Y., Wang, F., Xin, F."Cytotoxicity of Cichorium intybus L. metabolites (Review)". Oncology Reports 42.6 (2019): 2196-2212.
Chicago
Imam, K. M., Xie, Y., Liu, Y., Wang, F., Xin, F."Cytotoxicity of Cichorium intybus L. metabolites (Review)". Oncology Reports 42, no. 6 (2019): 2196-2212. https://doi.org/10.3892/or.2019.7336