|
1
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Kamisawa T, Wood LD, Itoi T and Takaori K:
Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Vivaldi C, Caparello C, Musettini G,
Pasquini G, Catanese S, Fornaro L, Lencioni M, Falcone A and Vasile
E: First-line treatment with FOLFOXIRI for advanced pancreatic
cancer in clinical practice: Patients' outcome and analysis of
prognostic factors. Int J Cancer. 139:938–945. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Takahara N, Isayama H, Nakai Y, Ishigami
H, Satoi S, Mizuno S, Kogure H, Matsubara S, Yamamoto N, Yamaguchi
H, et al: Intravenous and intraperitoneal paclitaxel with S-1 for
treatment of refractory pancreatic cancer with malignant ascites.
Investigational New Drugs. 34:636–642. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Thomassen I, Lemmens VE, Nienhuijs SW,
Luyer MD, Klaver YL and de Hingh IH: Incidence, prognosis, and
possible treatment strategies of peritoneal carcinomatosis of
pancreatic origin: A population-based study. Pancreas. 42:72–75.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Xu HB, Zheng LP, Li L, Xu LZ and Fu J:
Elemene, one ingredient of a Chinese herb, against malignant
tumors: A literature-based meta-analysis. Cancer Invest.
31:156–166. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Chang Z, Gao M, Zhang W, Song L, Jia Y and
Qin Y: Beta-elemene treatment is associated with improved outcomes
of patients with esophageal squamous cell carcinoma. Surg Oncol.
26:333–337. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Jiang X, Hidru TH, Zhang Z, Bai Y, Kong L
and Li X: Evidence of elemene injection combined radiotherapy in
lung cancer treatment among patients with brain metastases: A
systematic review and meta-analysis. Medicine (Baltimore).
96:e69632017. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Feng HB, Wang J, Jiang HR, Mei X, Zhao YY,
Chen FR, Qu Y, Sai K, Guo CC, Yang QY, et al: β-elemene selectively
inhibits the proliferation of glioma stem-like cells through the
downregulation of Notch1. Stem Cells Transl Med. 6:830–839. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Liu Y, Jiang ZY, Zhou YL, Qiu HH, Wang G,
Luo Y, Liu JB, Liu XW, Bu WQ, Song J, et al: β-elemene regulates
endoplasmic reticulum stress to induce the apoptosis of NSCLC cells
through PERK/IRE1α/ATF6 pathway. Biomed Pharmacother. 93:490–497.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Sun W, Huang Y, Yin T, Wang J, Du R, Qiu
J, Zhang Y, Wang Y, Chen J and Wang G: Effects of elemene on
inhibiting proliferation of vascular smooth muscle cells and
promoting reendothelialization at the stent implantation site.
Biomater Sci. 5:1144–1155. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Jiang Z, Jacob JA, Loganathachetti DS,
Nainangu P and Chen B: β-elemene: Mechanistic studies on cancer
cell interaction and its chemosensitization effect. Front
Pharmacol. 8:1052017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H,
Zhang J and Ye Q: β-elemene sensitizes hepatocellular carcinoma
cells to oxaliplatin by preventing oxaliplatin-induced degradation
of copper transporter 1. Sci Rep. 6:210102016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wang QT, Zhang ZL, Xiong H, Zhou DS, Li J,
Liang J and Wang YF: Evaluation of the efficacy and safety of
elemene in treating malignant pleural effusion caused by tumors: A
PRISMA guided meta-analysis. Medicine (Baltimore). 97:e125422018.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Wang J, Zhang H and Sun Y: Phase III
clinical trial of elemenum emulsion in the management of malignant
pleural and peritoneal effusions. Zhonghua Zhong Liu Za Zhi.
18:464–467. 1996.(In Chinese). PubMed/NCBI
|
|
16
|
Hu LP, Zhang XX, Jiang SH, Tao LY, Li Q,
Zhu LL, Yang MW, Huo YM, Jiang YS, Tian GA, et al: Targeting
purinergic receptor P2Y2 prevents the growth of pancreatic ductal
adenocarcinoma by inhibiting cancer cell glycolysis. Clin Cancer
Res. 25:1318–1330. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Wen Y, Zhou X, Lu M, He M, Tian Y, Liu L,
Wang M, Tan W, Deng Y, Yang X, et al: Bclaf1 promotes angiogenesis
by regulating HIF-1α transcription in hepatocellular carcinoma.
Oncogene. 38:1845–1859. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Li AG, Murphy EC, Culhane AC, Powell E,
Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ,
et al: BRCA1-IRIS promotes human tumor progression through PTEN
blockade and HIF-1α activation. Proc Natl Acad Sci USA.
115:E96002018. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Pérez S, Pereda J, Sabater L and Sastre J:
Pancreatic ascites hemoglobin contributes to the systemic response
in acute pancreatitis. Free Radic Biol Med. 81:145–155. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Pasquet M, Golzio M, Mery E, Rafii A,
Benabbou N, Mirshahi P, Hennebelle I, Bourin P, Allal B, Teissie J,
et al: Hospicells (ascites-derived stromal cells. promote
tumorigenicity and angiogenesis. Int J Cancer. 126:2090–2101.
2010.PubMed/NCBI
|
|
21
|
Song Y, Wu J, Oyesanya RA, Lee Z,
Mukherjee A and Fang X: Sp-1 and c-Myc mediate lysophosphatidic
acid-induced expression of vascular endothelial growth factor in
ovarian cancer cells via a hypoxia-inducible factor-1-independent
mechanism. Clin Cancer Res. 15:492–501. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Zou K, Tong E, Xu Y, Deng X and Zou L:
Down regulation of mammalian target of rapamycin decreases HIF-1α
and survivin expression in anoxic lung adenocarcinoma A549 cell to
elemene and/or irradiation. Tumor Biol. 35:9735–9741. 2014.
View Article : Google Scholar
|
|
23
|
Tong E, Xu Y, Li G, Zou K and Zou L: The
effects of β-elemene on the expression of mTOR, HIF-1A, survivin in
lung adenocarcinoma A549 cell. Afr J Tradit Complement Altern Med.
10:18–23. 2013.PubMed/NCBI
|
|
24
|
Li G, Xie B, Li X, Chen Y, Wang Q, Xu Y,
Xu-Welliver M and Zou L: Down-regulation of survivin and
hypoxia-inducible factor-1 α by β-elemene enhances the
radiosensitivity of lung adenocarcinoma xenograft. Cancer Biother
Radiopharm. 27:56–64. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Liu Z, Guo F, Wang Y, Li C, Zhang X, Li H,
Diao L, Gu J, Wang W, Li D, et al: BATMAN-TCM: A bioinformatics
analysis tool for molecular mechANism of traditional Chinese
medicine. Sci Rep. 6:211462016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Kim J, So S, Lee HJ, Park JC, Kim JJ and
Lee H: DigSee: Disease gene search engine with evidence sentences
(version cancer). Nucleic Acids Res. 41:W510–W517. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kim J, Kim JJ and Lee H: An analysis of
disease-gene relationship from Medline abstracts by DigSee. Sci
Rep. 7:40154. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Szklarczyk D, Morris JH, Cook H, Kuhn M,
Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al:
The STRING database in 2017: Quality-controlled protein-protein
association networks, made broadly accessible. Nucleic Acids Res.
45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Huang da W, Sherman BT and Lempicki RA:
Systematic and integrative analysis of large gene lists using DAVID
bioinformatics resources. Nature Protoc. 4:44–57. 2008. View Article : Google Scholar
|
|
30
|
Huang da W, Sherman BT and Lempicki RA:
Bioinformatics enrichment tools: Paths toward the comprehensive
functional analysis of large gene lists. Nucleic Acids Res.
37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Shannon P, Markiel A, Ozier O, Baliga NS,
Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A
software environment for integrated models of biomolecular
interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Goodsell DS and Olson AJ: Automated
docking of substrates to proteins by simulated annealing. Proteins.
8:195–202. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Schrödinger LLC: The PyMOL molecular
graphics system, version 1.8. 2015.
|
|
34
|
Tomczak K, Czerwińska P and Wiznerowicz M:
The Cancer Genome Atlas (TCGA): An immeasurable source of
knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI
|
|
35
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G,
Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al:
Integrative analysis of complex cancer genomics and clinical
profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Cerami E, Gao J, Dogrusoz U, Gross BE,
Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et
al: The cBio cancer genomics portal: An open platform for exploring
multidimensional cancer genomics data. Cancer Discov. 2:401–404.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Lánczky A, Nagy Á, Bottai G, Munkácsy G,
Szabó A, Santarpia L and Győrffy B: miRpower: A web-tool to
validate survival-associated miRNAs utilizing expression data from
2178 breast cancer patients. Breast Cancer Res Treat. 160:439–446.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
An YW, Hu G, Yin GP, Zhu JJ, Zhang QW,
Wang ZM, Peng J and Fan B: Quantitative analysis and discrimination
of steamed and non-steamed rhizomes of Curcuma wenyujin by
GC-MS and HPLC. J Chromatogr Sci. 52:961–970. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Tang CY, Zhu LX, Yu JD, Chen Z, Gu MC, Mu
CF, Liu Q and Xiong Y: Effect of β-elemene on the kinetics of
intracellular transport of d-luciferin potassium salt (ABC
substrate) in doxorubicin-resistant breast cancer cells and the
associated molecular mechanism. Eur J Pharm Sci. 120:20–29. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Li X, Wang G, Zhao J, Ding H, Cunningham
C, Chen F, Flynn DC, Reed E and Li QQ: Antiproliferative effect of
beta-elemene in chemoresistant ovarian carcinoma cells is mediated
through arrest of the cell cycle at the G2-M phase. Cell Mol Life
Sci. 62:894–904. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Liu JS, Che XM, Chang S, Qiu GL, He SC,
Fan L, Zhao W, Zhang ZL and Wang SF: β-elemene enhances the
radiosensitivity of gastric cancer cells by inhibiting Pak1
activation. World J Gastroenterol. 21:9945–9956. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Dai ZJ, Tang W, Lu WF, Gao J, Kang HF, Ma
XB, Min WL, Wang XJ and Wu WY: Antiproliferative and apoptotic
effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell
Int. 13:272013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Cheng H, Ge X, Zhuo S, Gao Y, Zhu B, Zhang
J, Shang W, Xu D, Ge W and Shi L: β-elemene synergizes with
gefitinib to inhibit stem-like phenotypes and progression of lung
cancer via down-regulating EZH2. Front Pharmacol. 9:14132018.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hopkins AL: Network pharmacology: The next
paradigm in drug discovery. Nat Chem Biol. 4:682–690. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zheng J, Wu M, Wang H and Li S, Wang X, Li
Y, Wang D and Li S: Network pharmacology to unveil the biological
basis of health-strengthening herbal medicine in cancer treatment.
Cancers (Basel). 10:E4612018. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Wang N, Yang B, Zhang X, Wang S, Zheng Y,
Li X, Liu S, Pan H, Li Y, Huang Z, et al: Network
pharmacology-based validation of caveolin-1 as a key mediator of Ai
Du Qing inhibition of drug resistance in breast cancer. Front
Pharmacol. 9:11062018. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Xing X, Chen S, Li L, Cao Y, Chen L, Wang
X and Zhu Z: The active components of Fuzheng Huayu formula and
their potential mechanism of action in inhibiting the hepatic
stellate cells viability-a network pharmacology and transcriptomics
approach. Front Pharmacol. 9:5252018. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Wang Y, Guo G, Yang BR, Xin QQ, Liao QW,
Lee SM, Hu YJ, Chen KJ and Cong WH: Synergistic effects of
Chuanxiong-Chishao herb-pair on promoting angiogenesis at network
pharmacological and pharmacodynamic levels. Chin J Integr Med.
23:654–662. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Kim A and Ma JY: Rhaponticin decreases the
metastatic and angiogenic abilities of cancer cells via suppression
of the HIF-1α pathway. Int J Oncol. 53:1160–1170. 2018.PubMed/NCBI
|
