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Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma

  • Authors:
    • Yong Cheng
    • Le Bai
    • Jingjie Shang
    • Yongjin Tang
    • Xueying Ling
    • Bin Guo
    • Jian Gong
    • Lu Wang
    • Hao Xu
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 177-187
    |
    Published online on: October 30, 2019
       https://doi.org/10.3892/or.2019.7392
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Abstract

The present study aimed to assess the performance of positron emission tomography‑magnetic resonance imaging (PET/MR) for the visualization and characterization of lesions. In addition, the present study investigated whether the apparent diffusion coefficient (ADC) and intravoxel incoherent motion parameters exhibited any significant correlation with standardized uptake values (SUV) in patients with nasopharyngeal carcinoma (NPC). A total of 35 patients with NPC underwent whole body PET‑computed tomography (CT) and head and neck MR imaging (MRI) scans using the PET/CT‑MRI system. Image quality, lesion conspicuity and the diagnostic confidence of PET/CT, T1 weighted (T1w) PET/MR and T2w PET/MR imaging were assessed. The true diffusion coefficient (D), the pseudo‑diffusion coefficient or diffusion within the microcirculation (D*), and the perfusion fraction or the contribution of water moving in the capillaries (f), and ADC, were calculated. The correlation between the ADC, D*, D and f values and the SUV were analyzed using Pearson's correlation analysis. Similar image quality was obtained using PET/CT, T1w PET/MR and T2w PET/MR imaging. However, the T1w PET/MR and T2w PET/MR imaging were more effective than PET/CT in analyzing the lesion conspicuity of the primary tumors and lymph nodes. In addition, T2w PET/MR imaging was more efficient than T1w PET/MR imaging in analyzing primary tumors and lymph nodes. Pearson's correlation analysis showed no significant correlation between the SUV and ADC, and D*, D and f values in NPC. The present results suggested that the application of PET/MR is feasible and could serve as a reliable alternative to PET/CT, while SUV and ADC, D*, D and f values were identified as independent biomarkers in NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Bai L, Shang J, Tang Y, Ling X, Guo B, Gong J, Wang L and Xu H: Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma. Oncol Rep 43: 177-187, 2020.
APA
Cheng, Y., Bai, L., Shang, J., Tang, Y., Ling, X., Guo, B. ... Xu, H. (2020). Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma. Oncology Reports, 43, 177-187. https://doi.org/10.3892/or.2019.7392
MLA
Cheng, Y., Bai, L., Shang, J., Tang, Y., Ling, X., Guo, B., Gong, J., Wang, L., Xu, H."Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma". Oncology Reports 43.1 (2020): 177-187.
Chicago
Cheng, Y., Bai, L., Shang, J., Tang, Y., Ling, X., Guo, B., Gong, J., Wang, L., Xu, H."Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma". Oncology Reports 43, no. 1 (2020): 177-187. https://doi.org/10.3892/or.2019.7392
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Bai L, Shang J, Tang Y, Ling X, Guo B, Gong J, Wang L and Xu H: Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma. Oncol Rep 43: 177-187, 2020.
APA
Cheng, Y., Bai, L., Shang, J., Tang, Y., Ling, X., Guo, B. ... Xu, H. (2020). Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma. Oncology Reports, 43, 177-187. https://doi.org/10.3892/or.2019.7392
MLA
Cheng, Y., Bai, L., Shang, J., Tang, Y., Ling, X., Guo, B., Gong, J., Wang, L., Xu, H."Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma". Oncology Reports 43.1 (2020): 177-187.
Chicago
Cheng, Y., Bai, L., Shang, J., Tang, Y., Ling, X., Guo, B., Gong, J., Wang, L., Xu, H."Preliminary clinical results for PET/MR compared with PET/CT in patients with nasopharyngeal carcinoma". Oncology Reports 43, no. 1 (2020): 177-187. https://doi.org/10.3892/or.2019.7392
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