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Article

Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition

  • Authors:
    • Xiaorong Deng
    • Cihua Zheng
    • Shuai Wang
    • Rong Yang
    • Zhaoxia Liu
    • Tingtao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 986-998
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    Published online on: January 14, 2020
       https://doi.org/10.3892/or.2020.7463
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Abstract

Abdominal adhesions refer to abnormal adhesions which cause a series of complications in numerous patients. In the present study, the beneficial effect of a combination of probiotics (Lactobacillus plantarum, L. acidophilus, L. rhamnosus and Bifidobacterium animalis) on abdominal adhesions in a rat model were verified. The present results indicated that probiotic treatment significantly reduced the levels of proinflammatory factors interleukin (IL)‑1β, IL‑6 and TNF‑α in serum and intestinal tissue (P<0.05), and markedly downregulated the inflammatory (TLR4/NF‑κB) and fibrotic (TGF‑β1/Smad) signalling pathways in intestinal tissue, especially in the prevention group (P<0.01). The high‑throughput sequencing results further supported that the probiotics significantly increased the relative abundance of probiotic Bacteroidetes (at the phylum level), Bacteroidales (at the order level), Lactobacillales (at the order level) and Lactobacillus (at the genus level), and markedly reduced the number of pathogenic Proteobacteria (at the phylum level), Erysipelotrichales (at the order level), Verrucomicrobiales (at the order level), Klebsiella (at the genus level) and Serratia (at the genus level). In conclusion, probiotics can effectively reduce abdominal adhesions by restoring the microbial balance and reducing inflammation and fibrosis caused by surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Deng X, Zheng C, Wang S, Yang R, Liu Z and Chen T: Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition. Oncol Rep 43: 986-998, 2020.
APA
Deng, X., Zheng, C., Wang, S., Yang, R., Liu, Z., & Chen, T. (2020). Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition. Oncology Reports, 43, 986-998. https://doi.org/10.3892/or.2020.7463
MLA
Deng, X., Zheng, C., Wang, S., Yang, R., Liu, Z., Chen, T."Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition". Oncology Reports 43.3 (2020): 986-998.
Chicago
Deng, X., Zheng, C., Wang, S., Yang, R., Liu, Z., Chen, T."Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition". Oncology Reports 43, no. 3 (2020): 986-998. https://doi.org/10.3892/or.2020.7463
Copy and paste a formatted citation
x
Spandidos Publications style
Deng X, Zheng C, Wang S, Yang R, Liu Z and Chen T: Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition. Oncol Rep 43: 986-998, 2020.
APA
Deng, X., Zheng, C., Wang, S., Yang, R., Liu, Z., & Chen, T. (2020). Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition. Oncology Reports, 43, 986-998. https://doi.org/10.3892/or.2020.7463
MLA
Deng, X., Zheng, C., Wang, S., Yang, R., Liu, Z., Chen, T."Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition". Oncology Reports 43.3 (2020): 986-998.
Chicago
Deng, X., Zheng, C., Wang, S., Yang, R., Liu, Z., Chen, T."Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition". Oncology Reports 43, no. 3 (2020): 986-998. https://doi.org/10.3892/or.2020.7463
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