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Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy

  • Authors:
    • Wenchuan Qi
    • Zhenhua Li
    • Chunlan Yang
    • Jiangshan Jiangshan Dai
    • Qiao Zhang
    • Di Wang
    • Chuanfang Wu
    • Longjiang Xia
    • Si Xu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Bio‑Resource and Eco‑Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, P.R. China, Department of Orthopedics, Changchun University of Traditional Chinese Medicine, Changchun, Jilin 130021, P.R. China, Department of Orthopedics, China‑Japan Friendship Hospital Affiliated Jilin University, Changchun, Jilin 130021, P.R. China, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 839-850
    |
    Published online on: January 29, 2020
       https://doi.org/10.3892/or.2020.7484
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Abstract

Traditionally, musk has been used as an analgesic to treat pain associated with cancer. Hepatocellular carcinoma (HCC) is an aggressive tumor; however, patients with liver cancer that received musk were reported to live longer and have a higher quality of life. Thus, the present study aimed to investigate whether muscone, a macrocyclic compound of musk, demonstrated potential as an anti‑liver cancer drug for the non‑surgical treatment of advanced liver cancer. Briefly, liver cancer cells were treated with muscone and the rates of cellular apoptosis and autophagy were investigated using staining techniques and western blotting. The underlying molecular mechanisms of muscone were evaluated using high‑throughput sequencing and the in vitro effects of muscone were subsequently validated in vivo using a nude mouse model. Muscone increased the rates of apoptosis and autophagy in liver cancer cells; the increase in cellular apoptosis was observed to occur through endoplasmic reticulum stress responses, whereas muscone‑induced autophagy was closely associated with the AMP kinase/mTOR complex 1 signaling pathway. These findings were verified in vivo. Notably, sestrin‑2 expression levels were also significantly decreased in liver cancer tissues compared with paracancerous tissues. In conclusion, the present study suggests that muscone demonstrates potential as an anticancer drug, and the findings of the present study provide the basis for the development of effective anticancer drugs derived from natural compounds.
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Copy and paste a formatted citation
Spandidos Publications style
Qi W, Li Z, Yang C, Jiangshan Dai J, Zhang Q, Wang D, Wu C, Xia L and Xu S: Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy. Oncol Rep 43: 839-850, 2020.
APA
Qi, W., Li, Z., Yang, C., Jiangshan Dai, J., Zhang, Q., Wang, D. ... Xu, S. (2020). Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy. Oncology Reports, 43, 839-850. https://doi.org/10.3892/or.2020.7484
MLA
Qi, W., Li, Z., Yang, C., Jiangshan Dai, J., Zhang, Q., Wang, D., Wu, C., Xia, L., Xu, S."Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy". Oncology Reports 43.3 (2020): 839-850.
Chicago
Qi, W., Li, Z., Yang, C., Jiangshan Dai, J., Zhang, Q., Wang, D., Wu, C., Xia, L., Xu, S."Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy". Oncology Reports 43, no. 3 (2020): 839-850. https://doi.org/10.3892/or.2020.7484
Copy and paste a formatted citation
x
Spandidos Publications style
Qi W, Li Z, Yang C, Jiangshan Dai J, Zhang Q, Wang D, Wu C, Xia L and Xu S: Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy. Oncol Rep 43: 839-850, 2020.
APA
Qi, W., Li, Z., Yang, C., Jiangshan Dai, J., Zhang, Q., Wang, D. ... Xu, S. (2020). Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy. Oncology Reports, 43, 839-850. https://doi.org/10.3892/or.2020.7484
MLA
Qi, W., Li, Z., Yang, C., Jiangshan Dai, J., Zhang, Q., Wang, D., Wu, C., Xia, L., Xu, S."Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy". Oncology Reports 43.3 (2020): 839-850.
Chicago
Qi, W., Li, Z., Yang, C., Jiangshan Dai, J., Zhang, Q., Wang, D., Wu, C., Xia, L., Xu, S."Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy". Oncology Reports 43, no. 3 (2020): 839-850. https://doi.org/10.3892/or.2020.7484
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