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Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT

  • Authors:
    • Kai Wang
    • Jianbao Zheng
    • Junhui Yu
    • Yunhua Wu
    • Jing Guo
    • Zhengshui Xu
    • Xuejun Sun
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1103-1112
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    Published online on: February 6, 2020
       https://doi.org/10.3892/or.2020.7490
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Abstract

The present study aimed to investigate the role of matrix metalloproteinase‑1 (MMP‑1) in the development of colorectal cancer and reveal the mechanism underlying this progression. Bioinformatics methods and a public dataset were first used to analyze MMP‑1 gene expression in a public dataset. MMP‑1 expression in colorectal cancer patients was assessed by immunohistochemistry; its association with clinicopathological parameters and its significance for prognosis were analyzed. Then proliferation, scratch and Transwell assays and a xenograft model were used to assess the change in malignant behavior in cells transfected with an MMP‑1 shRNA. Changes involved in epithelial‑mesenchymal transition (EMT) and the Akt signaling pathway were detected by western blotting. According to the results, MMP‑1 expression was higher in colorectal cancer tissues than it was in matched adjacent noncancerous tissues, and its high expression was significantly related to lymphatic metastasis as well as TNM stage (P<0.05). Downregulation of MMP‑1 expression inhibited the progression of colorectal cancer in vitro and in vivo. Furthermore, after the cells were stably transfected with MMP‑1 shRNA, the expression of N‑cadherin, vimentin and Twist1 decreased while that of E‑cadherin increased. The expression of p‑Akt and c‑Myc also decreased. In conclusion, MMP‑1 may promote malignant behavior in colorectal cancer via EMT and the Akt signaling pathway.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Favoriti P, Carbone G, Greco M, Pirozzi F, Pirozzi RE and Corcione F: Worldwide burden of colorectal cancer: A review. Updates Surg. 68:7–11. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Singh D, Srivastava SK, Chaudhuri TK and Upadhyay G: Multifaceted role of matrix metalloproteinases (MMPs). Front Mol Biosci. 2:192015. View Article : Google Scholar : PubMed/NCBI

6 

Gialeli C, Theocharis AD and Karamanos NK: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J. 278:16–27. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Page-McCaw A, Ewald AJ and Werb Z: Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 8:221–233. 2007. View Article : Google Scholar : PubMed/NCBI

8 

McCawley LJ and Matrisian LM: Matrix metalloproteinases: They're not just for matrix anymore. Curr Opin Cell Biol. 13:534–540. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Shintani T, Kusuhara Y, Daizumoto K, Dondoo TO, Yamamoto H, Mori H, Fukawa T, Nakatsuji H, Fukumori T, Takahashi M and Kanayama H: The involvement of hepatocyte growth Factor-MET-Matrix metalloproteinase 1 signaling in bladder cancer invasiveness and proliferation. Effect of the MET inhibitor, Cabozantinib (XL184), on bladder cancer cells. Urology. 101:169.e7–169.e13. 2017. View Article : Google Scholar

10 

Wang J, Liu D, Zhou W, Wang M, Xia W and Tang Q: Prognostic value of matrix metalloprotease-1/protease-activated receptor-1 axis in patients with prostate cancer. Med Oncol. 31:9682014. View Article : Google Scholar : PubMed/NCBI

11 

Kim M, Kim HJ, Choi BY, Kim JH, Song KS, Noh SM, Kim JC, Han DS, Kim SY and Kim YS: Identification of potential serum biomarkers for gastric cancer by a novel computational method, multiple normal tissues corrected differential analysis. Clin Chim Acta. 413:428–433. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Yamamoto H, Itoh F, Iku S, Adachi Y, Fukushima H, Sasaki S, Mukaiya M, Hirata K and Imai K: Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: Clinicopathologic and prognostic significance of matrilysin expression. J Clin Oncol. 19:1118–1127. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Pittayapruek P, Meephansan J, Prapapan O, Komine M and Ohtsuki M: Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 17(pii): E8682016. View Article : Google Scholar : PubMed/NCBI

14 

Saito R, Miki Y, Ishida N, Inoue C, Kobayashi M, Hata S, Yamada-Okabe H, Okada Y and Sasano H: The significance of MMP-1 in EGFR-TKI-resistant lung adenocarcinoma: Potential for therapeutic targeting. Int J Mol Sci. 19(pii): E6092018. View Article : Google Scholar : PubMed/NCBI

15 

Bendardaf R, Buhmeida A, Ristamäki R, Syrjänen K and Pyrhönen S: MMP-1 (collagenase-1) expression in primary colorectal cancer and its metastases. Scand J Gastroenterol. 42:1473–1478. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Shiozawa J, Ito M, Nakayama T, Nakashima M, Kohno S and Sekine I: Expression of matrix metalloproteinase-1 in human colorectal carcinoma. Mod Pathol. 13:925–933. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Gurzu S, Silveanu C, Fetyko A, Butiurca V, Kovacs Z and Jung I: Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancer. World J Gastroenterol. 22:6764–675. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Prieto-García E, Díaz-García CV, García-Ruiz I and Agulló-Ortuño MT: Epithelial-to-mesenchymal transition in tumor progression. Med Oncol. 34:1222017. View Article : Google Scholar : PubMed/NCBI

20 

Sakamoto T, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Kaneko N, Hashiguchi Y, Hattori T, Tanaka S, et al: Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. Oral Oncol. 69:15–25. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Jiang Y, Jiao Y, Liu Y, Zhang M, Wang Z, Li Y, Li T, Zhao X and Wang D: Sinomenine hydrochloride inhibits the metastasis of human glioblastoma cells by suppressing the expression of matrix Metalloproteinase-2/-9 and reversing the endogenous and exogenous Epithelial-mesenchymal transition. Int J Mol Sci. 9(pii): E8442018. View Article : Google Scholar

22 

Lee H, Ko JH, Baek SH, Nam D, Lee SG, Lee J, Yang WM, Um JY, Kim SH, Shim BS and Ahn KS: Embelin inhibits invasion and migration of MDA-MB-231 breast cancer cells by suppression of CXC chemokine receptor 4, matrix Metalloproteinases-9/2, and Epithelial-mesenchymal transition. Phytother Res. 30:1021–1032. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Chatterjee K, Jana S, DasMahapatra P and Swarnakar S: EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression. FASEB J. 32:4560–4572. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Zhao XL, Sun T, Che N, Sun D, Zhao N, Dong XY, Gu Q, Yao Z and Sun BC: Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1. J Cell Mol Med. 15:691–700. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Chen GH, Huang CH, Luo HY and Jiang ST: Effect of small interfering RNAs on matrix metalloproteinase 1 expression. Biotechnol Rep (Amst). 4:5–13. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Liu M, Hu Y, Zhang MF, Luo KJ, Xie XY, Wen J, Fu JH and Yang H: MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma. Cancer Lett. 377:97–104. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Langenskiöld M, Ivarsson ML, Holmdahl L, Falk P, Kåbjörn-Gustafsson C and Angenete E: Intestinal mucosal MMP-1-a prognostic factor in colon cancer. Scand J Gastroenterol. 48:563–569. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Bianco BC, Scotti FM, Vieira DS, Biz MT, Castro RG and Modolo F: Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. Int J Exp Pathol. 96:311–318. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Wang QM, Lv L, Tang Y, Zhang L and Wang LF: MMP-1 is overexpressed in triple-negative breast cancer tissues and the knockdown of MMP-1 expression inhibits tumor cell malignant behaviors in vitro. Oncol Lett. 17:1732–1740. 2019.PubMed/NCBI

30 

Eiró N, González LO, Atienza S, González-Quintana JM, Beridze N, Fernandez-Garcia B, Pérez-Fernández R, García-Caballero T, Schneider J and Vizoso FJ: Prediction of metastatic breast cancer in non-sentinel lymph nodes based on metalloprotease-1 expression by the sentinel lymph node. Eur J Cancer. 49:1009–1017. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Grimm M, Lazariotou M, Kircher S, Stuermer L, Reiber C, Höfelmayr A, Gattenlöhner S, Otto C, Germer CT and von Rahden BH: MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status. J Transl Med. 8:992010. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Z, Pan J, Li L, Wang Z, Xiao W and Li N: Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry. J Oral Pathol Med. 40:127–134. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Lassig AAD, Joseph AM, Lindgren BR and Yueh B: Association of oral cavity and oropharyngeal cancer biomarkers in surgical drain fluid with patient outcomes. JAMA Otolaryngol Head Neck Surg. 143:670–678. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Weiss MB, Abel EV, Mayberry MM, Basile KJ, Berger AC and Aplin AE: TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells. Cancer Res. 72:6382–6392. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Fuhrman-Luck RA, Stansfield SH, Stephens CR, Loessner D and Clements JA: Prostate Cancer-associated Kallikrein-related peptidase 4 activates matrix Metalloproteinase-1 and Thrombospondin-1. J Proteome Res. 15:2466–2478. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Huang C, Li Y, Guo Y, Zhang Z, Lian G, Chen Y, Li J, Su Y, Li J, Yang K, et al: MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells. Theranostics. 8:3074–3086. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Juncker-Jensen A, Deryugina EI, Rimann I, Zajac E, Kupriyanova TA, Engelholm LH and Quigley JP: Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination. Cancer Res. 73:4196–4211. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, et al: The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro Oncol. 17:1474–1485. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Hanrahan K, O'Neill A, Prencipe M, Bugler J, Murphy L, Fabre A, Puhr M, Culig Z, Murphy K and Watson RW: The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating Docetaxel-resistant prostate cancer. Mol Oncol. 11:251–265. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Pal I, Rajesh Y, Banik P, Dey G, Dey KK, Bharti R, Naskar D, Chakraborty S, Ghosh SK, Das SK, et al: Prevention of epithelial to mesenchymal transition in colorectal carcinoma by regulation of the E-cadherin-β-catenin-vinculin axis. Cancer Lett. 452:254–263. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Derycke LD and Bracke ME: N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Int J Dev Biol. 48:463–476. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Satelli A and Li S: Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci. 68:3033–3046. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Wang D, Rai B, Qi F, Liu T, Wang J, Wang X and Ma B: Influence of the Twist gene on the invasion and metastasis of colon cancer. Oncol Rep. 39:31–44. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang K, Zheng J, Yu J, Wu Y, Guo J, Xu Z and Sun X: Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT. Oncol Rep 43: 1103-1112, 2020.
APA
Wang, K., Zheng, J., Yu, J., Wu, Y., Guo, J., Xu, Z., & Sun, X. (2020). Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT. Oncology Reports, 43, 1103-1112. https://doi.org/10.3892/or.2020.7490
MLA
Wang, K., Zheng, J., Yu, J., Wu, Y., Guo, J., Xu, Z., Sun, X."Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT". Oncology Reports 43.4 (2020): 1103-1112.
Chicago
Wang, K., Zheng, J., Yu, J., Wu, Y., Guo, J., Xu, Z., Sun, X."Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT". Oncology Reports 43, no. 4 (2020): 1103-1112. https://doi.org/10.3892/or.2020.7490
Copy and paste a formatted citation
x
Spandidos Publications style
Wang K, Zheng J, Yu J, Wu Y, Guo J, Xu Z and Sun X: Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT. Oncol Rep 43: 1103-1112, 2020.
APA
Wang, K., Zheng, J., Yu, J., Wu, Y., Guo, J., Xu, Z., & Sun, X. (2020). Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT. Oncology Reports, 43, 1103-1112. https://doi.org/10.3892/or.2020.7490
MLA
Wang, K., Zheng, J., Yu, J., Wu, Y., Guo, J., Xu, Z., Sun, X."Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT". Oncology Reports 43.4 (2020): 1103-1112.
Chicago
Wang, K., Zheng, J., Yu, J., Wu, Y., Guo, J., Xu, Z., Sun, X."Knockdown of MMP‑1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c‑myc signaling pathway and EMT". Oncology Reports 43, no. 4 (2020): 1103-1112. https://doi.org/10.3892/or.2020.7490
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